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Results: 1 to 20 of 57

1.

Fumarate esters as angiogenesis inhibitors: key to action in psoriasis?

Arbiser JL.

J Invest Dermatol. 2011 Jun;131(6):1189-91. doi: 10.1038/jid.2011.45.

PMID:
21566578
[PubMed - indexed for MEDLINE]
Free Article
2.

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R.

Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386.

PMID:
21354971
[PubMed - indexed for MEDLINE]
Free Article
3.

Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level.

Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Essmann F.

Cell Death Differ. 2011 Jul;18(7):1130-9. doi: 10.1038/cdd.2010.179. Epub 2011 Jan 14.

PMID:
21233848
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Targeting glutathione by dimethylfumarate protects against experimental malaria by enhancing erythrocyte cell membrane scrambling.

Ghashghaeinia M, Bobbala D, Wieder T, Koka S, Brück J, Fehrenbacher B, Röcken M, Schaller M, Lang F, Ghoreschi K.

Am J Physiol Cell Physiol. 2010 Oct;299(4):C791-804. doi: 10.1152/ajpcell.00014.2010. Epub 2010 Jul 14.

PMID:
20631250
[PubMed - indexed for MEDLINE]
Free Article
5.

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.

Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C.

Nat Med. 2010 Apr;16(4):406-12. doi: 10.1038/nm.2110. Epub 2010 Mar 28.

PMID:
20348925
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Psoriasis.

Nestle FO, Kaplan DH, Barker J.

N Engl J Med. 2009 Jul 30;361(5):496-509. doi: 10.1056/NEJMra0804595. Review. No abstract available.

PMID:
19641206
[PubMed - indexed for MEDLINE]
7.

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair.

Rothfuss O, Fischer H, Hasegawa T, Maisel M, Leitner P, Miesel F, Sharma M, Bornemann A, Berg D, Gasser T, Patenge N.

Hum Mol Genet. 2009 Oct 15;18(20):3832-50. doi: 10.1093/hmg/ddp327. Epub 2009 Jul 19.

PMID:
19617636
[PubMed - indexed for MEDLINE]
Free Article
8.

AP-1 activated by toll-like receptors regulates expression of IL-23 p19.

Liu W, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, He JC, Abreu M, Unkeless JC, Mayer L, Xiong H.

J Biol Chem. 2009 Sep 4;284(36):24006-16. doi: 10.1074/jbc.M109.025528. Epub 2009 Jul 10.

PMID:
19592489
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation.

Kneilling M, Mailhammer R, Hültner L, Schönberger T, Fuchs K, Schaller M, Bukala D, Massberg S, Sander CA, Braumüller H, Eichner M, Maier KL, Hallmann R, Pichler BJ, Haubner R, Gawaz M, Pfeffer K, Biedermann T, Röcken M.

Blood. 2009 Aug 20;114(8):1696-706. doi: 10.1182/blood-2008-11-187682. Epub 2009 Jun 22.

PMID:
19546478
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.

Tzima S, Victoratos P, Kranidioti K, Alexiou M, Kollias G.

J Exp Med. 2009 May 11;206(5):1167-79. doi: 10.1084/jem.20081582. Epub 2009 Apr 27.

PMID:
19398754
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.

Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, Drake C, Pardoll D, Yu H.

Cancer Cell. 2009 Feb 3;15(2):114-23. doi: 10.1016/j.ccr.2008.12.018. Erratum in: Cancer Cell. 2010 Nov 16;18(5):536.

PMID:
19185846
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR; Collaborative Association Study of Psoriasis.

Nat Genet. 2009 Feb;41(2):199-204. doi: 10.1038/ng.311. Epub 2009 Jan 25.

PMID:
19169254
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study.

Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, O'Neill GN; BG-12 Phase IIb Study Investigators.

Lancet. 2008 Oct 25;372(9648):1463-72. doi: 10.1016/S0140-6736(08)61619-0. Erratum in: Lancet. 2009 Apr 18;373(9672):1340.

PMID:
18970976
[PubMed - indexed for MEDLINE]
14.

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study.

Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R, Kasper LH; Ustekinumab MS Investigators.

Lancet Neurol. 2008 Sep;7(9):796-804. doi: 10.1016/S1474-4422(08)70173-X.

PMID:
18703004
[PubMed - indexed for MEDLINE]
15.

Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia.

Kim HS, Cho IH, Kim JE, Shin YJ, Jeon JH, Kim Y, Yang YM, Lee KH, Lee JW, Lee WJ, Ye SK, Chung MH.

Free Radic Biol Med. 2008 Oct 1;45(7):950-63. doi: 10.1016/j.freeradbiomed.2008.06.009. Epub 2008 Jun 16.

PMID:
18625301
[PubMed - indexed for MEDLINE]
16.

A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription.

Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS.

J Immunol. 2007 Nov 15;179(10):6596-603.

PMID:
17982049
[PubMed - indexed for MEDLINE]
Free Article
17.

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskivina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop TD, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Matthew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop MG, Connell J, Dominiczak A, Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB, Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A; Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hilder SL, Hinks AM, John SL, Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B, Frayling TM, Freathy RM, Lango H, Perry JR, Shields BM, Weedon MN, Hattersley AT, Hitman GA, Walker M, Elliott KS, Groves CJ, Lindgren CM, Rayner NW, Timpson NJ, Zeggini E, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S; Breast Cancer Susceptibility Collaboration (UK), Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, Sirugo G, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE, Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P, Widden C, Withers D, Cardin NJ, Davison D, Ferreira T, Pereira-Gale J, Hallgrimsdo'ttir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Brown MA, Compston A, Farrall M, Hall AS, Hattersley AT, Hill AV, Parkes M, Pembrey M, Stratton MR, Mitchell SL, Newby PR, Brand OJ, Carr-Smith J, Pearce SH, McGinnis R, Keniry A, Deloukas P, Reveille JD, Zhou X, Sims AM, Dowling A, Taylor J, Doan T, Davis JC, Savage L, Ward MM, Learch TL, Weisman MH, Brown M.

Nat Genet. 2007 Nov;39(11):1329-37. Epub 2007 Oct 21.

PMID:
17952073
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.

Weber MS, Prod'homme T, Youssef S, Dunn SE, Rundle CD, Lee L, Patarroyo JC, Stüve O, Sobel RA, Steinman L, Zamvil SS.

Nat Med. 2007 Aug;13(8):935-43. Epub 2007 Aug 5.

PMID:
17676050
[PubMed - indexed for MEDLINE]
19.

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress.

Lin Q, Weis S, Yang G, Weng YH, Helston R, Rish K, Smith A, Bordner J, Polte T, Gaunitz F, Dennery PA.

J Biol Chem. 2007 Jul 13;282(28):20621-33. Epub 2007 Apr 12.

PMID:
17430897
[PubMed - indexed for MEDLINE]
Free Article
20.

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis.

Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, Dooley LT, Lebwohl M; CNTO 1275 Psoriasis Study Group.

N Engl J Med. 2007 Feb 8;356(6):580-92.

PMID:
17287478
[PubMed - indexed for MEDLINE]
Free Article
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