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References for PMC Articles for PubMed (Select 21946623)


SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.

Van Meter M, Mao Z, Gorbunova V, Seluanov A.

Cell Cycle. 2011 Sep 15;10(18):3153-8. Epub 2011 Sep 15.


Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.

Kawahara TL, Rapicavoli NA, Wu AR, Qu K, Quake SR, Chang HY.

PLoS Genet. 2011 Jun;7(6):e1002153. doi: 10.1371/journal.pgen.1002153. Epub 2011 Jun 30.


SIRT6 promotes DNA repair under stress by activating PARP1.

Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V.

Science. 2011 Jun 17;332(6036):1443-6. doi: 10.1126/science.1202723.


Structure and biochemical functions of SIRT6.

Pan PW, Feldman JL, Devries MK, Dong A, Edwards AM, Denu JM.

J Biol Chem. 2011 Apr 22;286(16):14575-87. doi: 10.1074/jbc.M111.218990. Epub 2011 Mar 1.


The DNA damage response: Balancing the scale between cancer and ageing.

Seviour EG, Lin SY.

Aging (Albany NY). 2010 Dec;2(12):900-7. Review.


Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA.

Cell. 2010 Nov 24;143(5):802-12. doi: 10.1016/j.cell.2010.10.002.


ATM activation by oxidative stress.

Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT.

Science. 2010 Oct 22;330(6003):517-21. doi: 10.1126/science.1192912.


SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, Jou W, Gius D, Deng CX.

J Biol Chem. 2010 Nov 19;285(47):36776-84. doi: 10.1074/jbc.M110.168039. Epub 2010 Sep 16.


Human SIRT6 promotes DNA end resection through CtIP deacetylation.

Kaidi A, Weinert BT, Choudhary C, Jackson SP.

Science. 2010 Sep 10;329(5997):1348-53. doi: 10.1126/science.1192049.


SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.

McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF.

Aging (Albany NY). 2009 Jan 15;1(1):109-21.


Sirtuins at the breaking point: SIRT6 in DNA repair.

Lombard DB.

Aging (Albany NY). 2009 Jan 20;1(1):12-6. No abstract available.


The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.

Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041.


SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.

Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D.

Cancer Cell. 2010 Jan 19;17(1):41-52. doi: 10.1016/j.ccr.2009.11.023.


SIRT6 protects against pathological damage caused by diet-induced obesity.

Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, Kronfeld-Schor N, Cohen HY.

Aging Cell. 2010 Apr;9(2):162-73. doi: 10.1111/j.1474-9726.2009.00544.x. Epub 2009 Dec 28.


JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.

Nasrin N, Kaushik VK, Fortier E, Wall D, Pearson KJ, de Cabo R, Bordone L.

PLoS One. 2009 Dec 22;4(12):e8414. doi: 10.1371/journal.pone.0008414.


Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF.

Cell Cycle. 2009 Aug 15;8(16):2664-6. Epub 2009 Aug 26. No abstract available.


The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.

Yang B, Zwaans BM, Eckersdorff M, Lombard DB.

Cell Cycle. 2009 Aug 15;8(16):2662-3. Epub 2009 Aug 22. No abstract available.


SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF.

Cell. 2009 Jan 9;136(1):62-74. doi: 10.1016/j.cell.2008.10.052.


SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.

Cell. 2008 Nov 28;135(5):907-18. doi: 10.1016/j.cell.2008.10.025.


Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, L├╝scher B.

Mol Cell. 2008 Oct 10;32(1):57-69. doi: 10.1016/j.molcel.2008.08.009.

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