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In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.

Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.

Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.


PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study.

Ozcan A, Shen SS, Hamilton C, Anjana K, Coffey D, Krishnan B, Truong LD.

Mod Pathol. 2011 Jun;24(6):751-64. doi: 10.1038/modpathol.2011.3. Epub 2011 Feb 11.


PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma.

Sangoi AR, Ohgami RS, Pai RK, Beck AH, McKenney JK, Pai RK.

Mod Pathol. 2011 Mar;24(3):412-24. doi: 10.1038/modpathol.2010.176. Epub 2010 Oct 1.


PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors.

Long KB, Srivastava A, Hirsch MS, Hornick JL.

Am J Surg Pathol. 2010 May;34(5):723-9. doi: 10.1097/PAS.0b013e3181da0a20.


PAX5 expression in nonhematopoietic tissues. Reappraisal of previous studies.

Morgenstern DA, Hasan F, Gibson S, Winyard P, Sebire NJ, Anderson J.

Am J Clin Pathol. 2010 Mar;133(3):407-15. doi: 10.1309/AJCPZPQN0LUGKMME.


The PAX258 gene subfamily: a comparative perspective.

Goode DK, Elgar G.

Dev Dyn. 2009 Dec;238(12):2951-74. doi: 10.1002/dvdy.22146. Review.


The transcriptional response of the islet to pregnancy in mice.

Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD, Kaestner KH.

Mol Endocrinol. 2009 Oct;23(10):1702-12. doi: 10.1210/me.2009-0144. Epub 2009 Jul 2.


Detailed transcriptome atlas of the pancreatic beta cell.

Kutlu B, Burdick D, Baxter D, Rasschaert J, Flamez D, Eizirik DL, Welsh N, Goodman N, Hood L.

BMC Med Genomics. 2009 Jan 15;2:3. doi: 10.1186/1755-8794-2-3.


Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort.

Elbein SC, Das SK, Hallman DM, Hanis CL, Hasstedt SJ.

Diabetes. 2009 Jan;58(1):268-74. doi: 10.2337/db08-0931. Epub 2008 Oct 7.


A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease.

Brun T, Gauthier BR.

J Mol Endocrinol. 2008 Feb;40(2):37-45. doi: 10.1677/JME-07-0134. Review.


The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

Brun T, Hu He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR.

Hum Mol Genet. 2008 Feb 15;17(4):478-89. Epub 2007 Nov 7.


PAX genes: roles in development, pathophysiology, and cancer.

Lang D, Powell SK, Plummer RS, Young KP, Ruggeri BA.

Biochem Pharmacol. 2007 Jan 1;73(1):1-14. Epub 2006 Aug 14. Review.


A PANorama of PAX genes in cancer and development.

Robson EJ, He SJ, Eccles MR.

Nat Rev Cancer. 2006 Jan;6(1):52-62. Review.


The gene Pax4 is an essential regulator of pancreatic beta-cell development.

Sosa-Pineda B.

Mol Cells. 2004 Dec 31;18(3):289-94. Review.


The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.

Brun T, Franklin I, St-Onge L, Biason-Lauber A, Schoenle EJ, Wollheim CB, Gauthier BR.

J Cell Biol. 2004 Dec 20;167(6):1123-35. Epub 2004 Dec 13.


Transcriptional networks controlling pancreatic development and beta cell function.

Servitja JM, Ferrer J.

Diabetologia. 2004 Apr;47(4):597-613. Review.


The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter.

Ritz-Laser B, Estreicher A, Gauthier B, Philippe J.

J Biol Chem. 2000 Oct 20;275(42):32708-15.


Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.

St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P.

Nature. 1997 May 22;387(6631):406-9.

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