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Results: 1 to 20 of 38

1.

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A.

Dev Cell. 2011 Apr 19;20(4):419-29. doi: 10.1016/j.devcel.2011.03.012.

PMID:
21497756
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.

Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH.

Diabetes. 2011 Feb;60(2):391-7. doi: 10.2337/db10-0426.

PMID:
21270251
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Paracrinology of islets and the paracrinopathy of diabetes.

Unger RH, Orci L.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16009-12. doi: 10.1073/pnas.1006639107. Epub 2010 Aug 26.

PMID:
20798346
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice.

Hancock AS, Du A, Liu J, Miller M, May CL.

Mol Endocrinol. 2010 Aug;24(8):1605-14. doi: 10.1210/me.2010-0120. Epub 2010 Jun 30. Erratum in: Mol Endocrinol. 2010 Oct;24(10):2072.

PMID:
20592160
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL.

Nature. 2010 Apr 22;464(7292):1149-54. doi: 10.1038/nature08894. Epub 2010 Apr 4.

PMID:
20364121
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Unique arrangement of alpha- and beta-cells in human islets of Langerhans.

Bosco D, Armanet M, Morel P, Niclauss N, Sgroi A, Muller YD, Giovannoni L, Parnaud G, Berney T.

Diabetes. 2010 May;59(5):1202-10. doi: 10.2337/db09-1177. Epub 2010 Feb 25.

PMID:
20185817
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells.

Hayashi Y, Yamamoto M, Mizoguchi H, Watanabe C, Ito R, Yamamoto S, Sun XY, Murata Y.

Mol Endocrinol. 2009 Dec;23(12):1990-9. doi: 10.1210/me.2009-0296. Epub 2009 Oct 9.

PMID:
19819987
[PubMed - indexed for MEDLINE]
8.

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors.

Desgraz R, Herrera PL.

Development. 2009 Nov;136(21):3567-74. doi: 10.1242/dev.039214. Epub 2009 Sep 30.

PMID:
19793886
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia.

Gu W, Yan H, Winters KA, Komorowski R, Vonderfecht S, Atangan L, Sivits G, Hill D, Yang J, Bi V, Shen Y, Hu S, Boone T, Lindberg RA, Véniant MM.

J Pharmacol Exp Ther. 2009 Dec;331(3):871-81. doi: 10.1124/jpet.109.157685. Epub 2009 Aug 31.

PMID:
19720878
[PubMed - indexed for MEDLINE]
Free Article
10.

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A.

Cell. 2009 Aug 7;138(3):449-62. doi: 10.1016/j.cell.2009.05.035.

PMID:
19665969
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor.

Zhou C, Dhall D, Nissen NN, Chen CR, Yu R.

Pancreas. 2009 Nov;38(8):941-6. doi: 10.1097/MPA.0b013e3181b2bb03.

PMID:
19657311
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.

Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007.

PMID:
19356716
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys.

Yan H, Gu W, Yang J, Bi V, Shen Y, Lee E, Winters KA, Komorowski R, Zhang C, Patel JJ, Caughey D, Elliott GS, Lau YY, Wang J, Li YS, Boone T, Lindberg RA, Hu S, Véniant MM.

J Pharmacol Exp Ther. 2009 Apr;329(1):102-11. doi: 10.1124/jpet.108.147009. Epub 2009 Jan 7.

PMID:
19129372
[PubMed - indexed for MEDLINE]
Free Article
14.

Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas.

Henopp T, Anlauf M, Schmitt A, Schlenger R, Zalatnai A, Couvelard A, Ruszniewski P, Schaps KP, Jonkers YM, Speel EJ, Pellegata NS, Heitz PU, Komminoth P, Perren A, Klöppel G.

J Clin Endocrinol Metab. 2009 Jan;94(1):213-7. doi: 10.1210/jc.2008-1300. Epub 2008 Oct 28.

PMID:
18957496
[PubMed - indexed for MEDLINE]
15.

Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes.

Quesada I, Tudurí E, Ripoll C, Nadal A.

J Endocrinol. 2008 Oct;199(1):5-19. doi: 10.1677/JOE-08-0290. Epub 2008 Jul 31. Review.

PMID:
18669612
[PubMed - indexed for MEDLINE]
Free Article
16.

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.

Strom A, Bonal C, Ashery-Padan R, Hashimoto N, Campos ML, Trumpp A, Noda T, Kido Y, Real FX, Thorel F, Herrera PL.

Development. 2007 Aug;134(15):2719-25. Epub 2007 Jun 27.

PMID:
17596282
[PubMed - indexed for MEDLINE]
Free Article
17.

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A.

J Clin Invest. 2007 Apr;117(4):961-70.

PMID:
17404619
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.

Gromada J, Franklin I, Wollheim CB.

Endocr Rev. 2007 Feb;28(1):84-116. Epub 2007 Jan 16. Review.

PMID:
17261637
[PubMed - indexed for MEDLINE]
19.

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.

Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G.

Endocrinology. 2006 Sep;147(9):3995-4006. Epub 2006 Apr 20.

PMID:
16627579
[PubMed - indexed for MEDLINE]
20.

Glucagon: the effects of its excess and deficiency on insulin action.

Fanelli CG, Porcellati F, Rossetti P, Bolli GB.

Nutr Metab Cardiovasc Dis. 2006 Mar;16 Suppl 1:S28-34. Epub 2006 Feb 9. Review.

PMID:
16530126
[PubMed - indexed for MEDLINE]

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