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Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.

Broz P, von Moltke J, Jones JW, Vance RE, Monack DM.

Cell Host Microbe. 2010 Dec 16;8(6):471-83. doi: 10.1016/j.chom.2010.11.007.


Adenovirus membrane penetration activates the NLRP3 inflammasome.

Barlan AU, Griffin TM, McGuire KA, Wiethoff CM.

J Virol. 2011 Jan;85(1):146-55. doi: 10.1128/JVI.01265-10. Epub 2010 Oct 27.


Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication.

Motani K, Kawase K, Imamura R, Kinoshita T, Kushiyama H, Suda T.

Cancer Sci. 2010 Aug;101(8):1822-7. doi: 10.1111/j.1349-7006.2010.01610.x. Epub 2010 May 3.


Inflammasome and IL-1beta-mediated disorders.

Hoffman HM, Wanderer AA.

Curr Allergy Asthma Rep. 2010 Jul;10(4):229-35. doi: 10.1007/s11882-010-0109-z. Review.


Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.

Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, Portnoy DA.

Cell Host Microbe. 2010 May 20;7(5):412-9. doi: 10.1016/j.chom.2010.04.004. Epub 2010 Apr 22.


Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.

Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T.

J Immunol. 2010 May 15;184(10):5874-84. doi: 10.4049/jimmunol.0900779. Epub 2010 Apr 14.


The inflammasomes.

Schroder K, Tschopp J.

Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040. Review.


Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent.

Averette KM, Pratt MR, Yang Y, Bassilian S, Whitelegge JP, Loo JA, Muir TW, Bradley KA.

PLoS One. 2009 Nov 18;4(11):e7913. doi: 10.1371/journal.pone.0007913.


Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.

Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA.

PLoS One. 2009 Oct 14;4(10):e7446. doi: 10.1371/journal.pone.0007446.


Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK.

Cell. 2009 Jun 12;137(6):1112-23. doi: 10.1016/j.cell.2009.05.037.


Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.

He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X.

Cell. 2009 Jun 12;137(6):1100-11. doi: 10.1016/j.cell.2009.05.021.


RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J.

Science. 2009 Jul 17;325(5938):332-6. doi: 10.1126/science.1172308. Epub 2009 Jun 4.


Mechanism and repertoire of ASC-mediated gene expression.

Hasegawa M, Imamura R, Motani K, Nishiuchi T, Matsumoto N, Kinoshita T, Suda T.

J Immunol. 2009 Jun 15;182(12):7655-62. doi: 10.4049/jimmunol.0800448.


Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.

Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP.

J Immunol. 2009 May 15;182(10):6460-9. doi: 10.4049/jimmunol.0802696.


The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G.

Nat Immunol. 2009 Mar;10(3):241-7. doi: 10.1038/ni.1703. Review.


Pyroptosis: host cell death and inflammation.

Bergsbaken T, Fink SL, Cookson BT.

Nat Rev Microbiol. 2009 Feb;7(2):99-109. doi: 10.1038/nrmicro2070. Review.


Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J.

Cell. 2008 Dec 26;135(7):1311-23. doi: 10.1016/j.cell.2008.10.044.


Identification of RIP1 kinase as a specific cellular target of necrostatins.

Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J.

Nat Chem Biol. 2008 May;4(5):313-21. doi: 10.1038/nchembio.83.


Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA.

J Exp Med. 2007 Dec 24;204(13):3235-45. Epub 2007 Dec 10.


Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP.

Cell Host Microbe. 2007 Sep 13;2(3):147-59.

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