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The ISG56/IFIT1 gene family.

Fensterl V, Sen GC.

J Interferon Cytokine Res. 2011 Jan;31(1):71-8. doi: 10.1089/jir.2010.0101. Epub 2010 Oct 15. Review.


Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin.

Lee JH, Bae JA, Lee JH, Seo YW, Kho DH, Sun EG, Lee SE, Cho SH, Joo YE, Ahn KY, Chung IJ, Kim KK.

Gut. 2010 Jul;59(7):907-17. doi: 10.1136/gut.2009.194068.


Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes.

Tsuchiya K, Hara H, Kawamura I, Nomura T, Yamamoto T, Daim S, Dewamitta SR, Shen Y, Fang R, Mitsuyama M.

J Immunol. 2010 Jul 15;185(2):1186-95. doi: 10.4049/jimmunol.1001058. Epub 2010 Jun 21.


Activation of host pattern recognition receptors by viruses.

Brennan K, Bowie AG.

Curr Opin Microbiol. 2010 Aug;13(4):503-7. doi: 10.1016/j.mib.2010.05.007. Epub 2010 Jun 9. Review.


Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

Jones JW, Kayagaki N, Broz P, Henry T, Newton K, O'Rourke K, Chan S, Dong J, Qu Y, Roose-Girma M, Dixit VM, Monack DM.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6. doi: 10.1073/pnas.1003738107. Epub 2010 May 10.


Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.

Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, Portnoy DA.

Cell Host Microbe. 2010 May 20;7(5):412-9. doi: 10.1016/j.chom.2010.04.004. Epub 2010 Apr 22.


The AIM2 inflammasome is critical for innate immunity to Francisella tularensis.

Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J, Datta P, McCormick M, Huang L, McDermott E, Eisenlohr L, Landel CP, Alnemri ES.

Nat Immunol. 2010 May;11(5):385-93. doi: 10.1038/ni.1859. Epub 2010 Mar 28.


The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.

Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA.

Nat Immunol. 2010 May;11(5):395-402. doi: 10.1038/ni.1864. Epub 2010 Mar 28.


Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes.

Michel S, Linnebacher M, Alcaniz J, Voss M, Wagner R, Dippold W, Becker C, von Knebel Doeberitz M, Ferrone S, Kloor M.

Int J Cancer. 2010 Aug 15;127(4):889-98. doi: 10.1002/ijc.25106.


Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.

Michel S, Kloor M, Singh S, Gdynia G, Roth W, von Knebel Doeberitz M, Schirmacher P, Bläker H.

Mol Carcinog. 2010 Feb;49(2):175-82. doi: 10.1002/mc.20587.


Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells.

Patsos G, Germann A, Gebert J, Dihlmann S.

Int J Cancer. 2010 Apr 15;126(8):1838-49. doi: 10.1002/ijc.24905.


HLA-DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers.

Walsh MD, Dent OF, Young JP, Wright CM, Barker MA, Leggett BA, Bokey L, Chapuis PH, Jass JR, Macdonald GA.

Int J Cancer. 2009 Sep 1;125(5):1231-7. doi: 10.1002/ijc.24484.


Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Schroder K, Muruve DA, Tschopp J.

Curr Biol. 2009 Mar 24;19(6):R262-5. doi: 10.1016/j.cub.2009.02.011.


MHC Class II alleles in ulcerative colitis-associated colorectal cancer.

Garrity-Park MM, Loftus EV Jr, Sandborn WJ, Bryant SC, Smyrk TC.

Gut. 2009 Sep;58(9):1226-33. doi: 10.1136/gut.2008.166686. Epub 2009 Feb 26.


An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.

Bürckstümmer T, Baumann C, Blüml S, Dixit E, Dürnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G.

Nat Immunol. 2009 Mar;10(3):266-72. doi: 10.1038/ni.1702. Epub 2009 Jan 21.


AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.

Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES.

Nature. 2009 Mar 26;458(7237):509-13. doi: 10.1038/nature07710. Epub 2009 Jan 21.


AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.

Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA.

Nature. 2009 Mar 26;458(7237):514-8. doi: 10.1038/nature07725. Epub 2009 Jan 21.


HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA.

Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ.

Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009 Jan 8.


G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.

Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC.

J Clin Invest. 2007 Oct;117(10):3107-17.


The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.

Woerner SM, Kloor M, Schwitalle Y, Youmans H, Doeberitz Mv, Gebert J, Dihlmann S.

Genes Chromosomes Cancer. 2007 Dec;46(12):1080-9.

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