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Items: 1 to 20 of 47


Elongator: an ancestral complex driving transcription and migration through protein acetylation.

Creppe C, Buschbeck M.

J Biomed Biotechnol. 2011;2011:924898. doi: 10.1155/2011/924898. Epub 2011 Jan 12. Review.


The ins and outs of tubulin acetylation: more than just a post-translational modification?

Perdiz D, Mackeh R, Poüs C, Baillet A.

Cell Signal. 2011 May;23(5):763-71. doi: 10.1016/j.cellsig.2010.10.014. Epub 2010 Oct 19. Review.


Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.

Tapia M, Wandosell F, Garrido JJ.

PLoS One. 2010 Sep 23;5(9):e12908. doi: 10.1371/journal.pone.0012908.


Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.

Quinti L, Chopra V, Rotili D, Valente S, Amore A, Franci G, Meade S, Valenza M, Altucci L, Maxwell MM, Cattaneo E, Hersch S, Mai A, Kazantsev A.

PLoS Curr. 2010 Sep 2;2. pii: RRN1172. doi: 10.1371/currents.RRN1172.


Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.

Janke C, Kneussel M.

Trends Neurosci. 2010 Aug;33(8):362-72. doi: 10.1016/j.tins.2010.05.001. Epub 2010 Jun 11. Review.


HDAC6 regulates mitochondrial transport in hippocampal neurons.

Chen S, Owens GC, Makarenkova H, Edelman DB.

PLoS One. 2010 May 26;5(5):e10848. doi: 10.1371/journal.pone.0010848.


Aging and disease: connections to sirtuins.

Donmez G, Guarente L.

Aging Cell. 2010 Apr;9(2):285-90. doi: 10.1111/j.1474-9726.2010.00548.x. Review.


SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.

Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, Moffitt H, Smith DL, Runne H, Gokce O, Kuhn A, Xiang Z, Maxwell MM, Reeves SA, Bates GP, Neri C, Thompson LM, Marsh JL, Kazantsev AG.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. doi: 10.1073/pnas.1002924107. Epub 2010 Apr 8.


The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.

Solinger JA, Paolinelli R, Klöss H, Scorza FB, Marchesi S, Sauder U, Mitsushima D, Capuani F, Stürzenbaum SR, Cassata G.

PLoS Genet. 2010 Jan 22;6(1):e1000820. doi: 10.1371/journal.pgen.1000820.


Elongator - an emerging role in neurological disorders.

Nguyen L, Humbert S, Saudou F, Chariot A.

Trends Mol Med. 2010 Jan;16(1):1-6. doi: 10.1016/j.molmed.2009.11.002. Epub 2009 Dec 23.


Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons.

Hammond JW, Huang CF, Kaech S, Jacobson C, Banker G, Verhey KJ.

Mol Biol Cell. 2010 Feb 15;21(4):572-83. doi: 10.1091/mbc.E09-01-0044. Epub 2009 Dec 23.


SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology.

Harting K, Knöll B.

Eur J Cell Biol. 2010 Feb-Mar;89(2-3):262-9. doi: 10.1016/j.ejcb.2009.11.006. Epub 2009 Dec 11. Review.


Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.

J Neurosci Res. 2010 Jan;88(1):179-90. doi: 10.1002/jnr.22184.


Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin.

Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L.

Cell. 2009 Feb 6;136(3):551-64. doi: 10.1016/j.cell.2008.11.043. Epub 2009 Jan 29.


Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity.

Pfister JA, Ma C, Morrison BE, D'Mello SR.

PLoS One. 2008;3(12):e4090. doi: 10.1371/journal.pone.0004090. Epub 2008 Dec 31.


SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.

Wang F, Tong Q.

Mol Biol Cell. 2009 Feb;20(3):801-8. doi: 10.1091/mbc.E08-06-0647. Epub 2008 Nov 26.


Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.

Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A.

Hum Mol Genet. 2009 Feb 1;18(3):472-81. doi: 10.1093/hmg/ddn375. Epub 2008 Nov 7.


Biological and potential therapeutic roles of sirtuin deacetylases.

Taylor DM, Maxwell MM, Luthi-Carter R, Kazantsev AG.

Cell Mol Life Sci. 2008 Dec;65(24):4000-18. doi: 10.1007/s00018-008-8357-y. Review.


Role of axonal transport in neurodegenerative diseases.

De Vos KJ, Grierson AJ, Ackerley S, Miller CC.

Annu Rev Neurosci. 2008;31:151-73. doi: 10.1146/annurev.neuro.31.061307.090711. Review.


The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility.

Pandithage R, Lilischkis R, Harting K, Wolf A, Jedamzik B, Lüscher-Firzlaff J, Vervoorts J, Lasonder E, Kremmer E, Knöll B, Lüscher B.

J Cell Biol. 2008 Mar 10;180(5):915-29. doi: 10.1083/jcb.200707126.

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