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Items: 1 to 20 of 23


Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.

Labbadia J, Cunliffe H, Weiss A, Katsyuba E, Sathasivam K, Seredenina T, Woodman B, Moussaoui S, Frentzel S, Luthi-Carter R, Paganetti P, Bates GP.

J Clin Invest. 2011 Aug;121(8):3306-19. doi: 10.1172/JCI57413. Epub 2011 Jul 25.


Huntington's disease: can mice lead the way to treatment?

Crook ZR, Housman D.

Neuron. 2011 Feb 10;69(3):423-35. doi: 10.1016/j.neuron.2010.12.035. Review. Erratum in: Neuron. 2011 Mar 10;69(5):1038.


Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms.

Jarosz DF, Taipale M, Lindquist S.

Annu Rev Genet. 2010;44:189-216. doi: 10.1146/annurev.genet.40.110405.090412. Review.


Emergence and natural selection of drug-resistant prions.

Shorter J.

Mol Biosyst. 2010 Jul;6(7):1115-30. doi: 10.1039/c004550k. Epub 2010 Apr 27. Review.


Prion-like disorders: blurring the divide between transmissibility and infectivity.

Cushman M, Johnson BS, King OD, Gitler AD, Shorter J.

J Cell Sci. 2010 Apr 15;123(Pt 8):1191-201. doi: 10.1242/jcs.051672.


Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.

Neef DW, Turski ML, Thiele DJ.

PLoS Biol. 2010 Jan 19;8(1):e1000291. doi: 10.1371/journal.pbio.1000291.


Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity.

Nekooki-Machida Y, Kurosawa M, Nukina N, Ito K, Oda T, Tanaka M.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9679-84. doi: 10.1073/pnas.0812083106. Epub 2009 Jun 1.


Biological and chemical approaches to diseases of proteostasis deficiency.

Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE.

Annu Rev Biochem. 2009;78:959-91. doi: 10.1146/annurev.biochem.052308.114844. Review.


Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.

Duennwald ML, Lindquist S.

Genes Dev. 2008 Dec 1;22(23):3308-19. doi: 10.1101/gad.1673408. Epub 2008 Nov 17.


Chemical and biological approaches synergize to ameliorate protein-folding diseases.

Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR 3rd, Segatori L, Kelly JW.

Cell. 2008 Sep 5;134(5):769-81. doi: 10.1016/j.cell.2008.06.037.


Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13626-31. doi: 10.1073/pnas.0806319105. Epub 2008 Aug 29.


Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.

Lo Bianco C, Shorter J, RĂ©gulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P.

J Clin Invest. 2008 Sep;118(9):3087-97. doi: 10.1172/JCI35781.


Adapting proteostasis for disease intervention.

Balch WE, Morimoto RI, Dillin A, Kelly JW.

Science. 2008 Feb 15;319(5865):916-9. doi: 10.1126/science.1141448. Review.


Heat shock response modulators as therapeutic tools for diseases of protein conformation.

Westerheide SD, Morimoto RI.

J Biol Chem. 2005 Sep 30;280(39):33097-100. Epub 2005 Aug 1. Review.


Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.

Fujimoto M, Takaki E, Hayashi T, Kitaura Y, Tanaka Y, Inouye S, Nakai A.

J Biol Chem. 2005 Oct 14;280(41):34908-16. Epub 2005 Jul 28.


Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach.

Hay DG, Sathasivam K, Tobaben S, Stahl B, Marber M, Mestril R, Mahal A, Smith DL, Woodman B, Bates GP.

Hum Mol Genet. 2004 Jul 1;13(13):1389-405. Epub 2004 Apr 28.


Hsp90 and chromatin: where is the link?

Sangster TA, Queitsch C, Lindquist S.

Cell Cycle. 2003 May-Jun;2(3):166-8. Review. No abstract available.


Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.

Sollars V, Lu X, Xiao L, Wang X, Garfinkel MD, Ruden DM.

Nat Genet. 2003 Jan;33(1):70-4. Epub 2002 Dec 16.


Pharmacological prevention of Parkinson disease in Drosophila.

Auluck PK, Bonini NM.

Nat Med. 2002 Nov;8(11):1185-6. No abstract available.


Geldanamycin restores a defective heat shock response in vivo.

Winklhofer KF, Reintjes A, Hoener MC, Voellmy R, Tatzelt J.

J Biol Chem. 2001 Nov 30;276(48):45160-7. Epub 2001 Sep 26.

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