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Items: 1 to 20 of 68

1.

HIV-1 Integrase-DNA Recognition Mechanisms.

Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M.

Viruses. 2009 Dec;1(3):713-36. doi: 10.3390/v1030713. Epub 2009 Nov 5.

2.

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.

Tsiang M, Jones GS, Hung M, Samuel D, Novikov N, Mukund S, Brendza KM, Niedziela-Majka A, Jin D, Liu X, Mitchell M, Sakowicz R, Geleziunas R.

Biochemistry. 2011 Mar 15;50(10):1567-81. doi: 10.1021/bi101504w. Epub 2011 Feb 21.

PMID:
21222490
3.

Structure-based modeling of the functional HIV-1 intasome and its inhibition.

Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman A.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15910-5. doi: 10.1073/pnas.1002346107. Epub 2010 Aug 23.

4.

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, Bardiot D, Van der Veken NJ, Van Remoortel B, Strelkov SV, De Maeyer M, Chaltin P, Debyser Z.

Nat Chem Biol. 2010 Jun;6(6):442-8. doi: 10.1038/nchembio.370. Epub 2010 May 16.

PMID:
20473303
5.

Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy.

Kotova S, Li M, Dimitriadis EK, Craigie R.

J Mol Biol. 2010 Jun 11;399(3):491-500. doi: 10.1016/j.jmb.2010.04.026. Epub 2010 Apr 21.

6.

Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD.

J Biol Chem. 2010 Jun 25;285(26):20303-15. doi: 10.1074/jbc.M110.114413. Epub 2010 Apr 20.

7.

Retroviral intasome assembly and inhibition of DNA strand transfer.

Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P.

Nature. 2010 Mar 11;464(7286):232-6. doi: 10.1038/nature08784. Epub 2010 Jan 31.

8.

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.

Tsiang M, Jones GS, Hung M, Mukund S, Han B, Liu X, Babaoglu K, Lansdon E, Chen X, Todd J, Cai T, Pagratis N, Sakowicz R, Geleziunas R.

J Biol Chem. 2009 Nov 27;284(48):33580-99. doi: 10.1074/jbc.M109.040121. Epub 2009 Sep 28.

9.

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.

Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR Jr, Kvaratskhelia M.

Mol Pharmacol. 2009 Oct;76(4):824-32. doi: 10.1124/mol.109.058883. Epub 2009 Jul 28.

10.

Structural basis for functional tetramerization of lentiviral integrase.

Hare S, Di Nunzio F, Labeja A, Wang J, Engelman A, Cherepanov P.

PLoS Pathog. 2009 Jul;5(7):e1000515. doi: 10.1371/journal.ppat.1000515. Epub 2009 Jul 17.

11.

Nucleoprotein complex intermediates in HIV-1 integration.

Li M, Craigie R.

Methods. 2009 Apr;47(4):237-42. doi: 10.1016/j.ymeth.2009.02.001. Epub 2009 Feb 20.

12.

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.

Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M.

EMBO J. 2009 Apr 8;28(7):980-91. doi: 10.1038/emboj.2009.41. Epub 2009 Feb 19.

13.

Time-resolved fluorescence resonance energy transfer study shows a compact denatured state of the B domain of protein A.

Huang F, Lerner E, Sato S, Amir D, Haas E, Fersht AR.

Biochemistry. 2009 Apr 21;48(15):3468-76. doi: 10.1021/bi801890w.

PMID:
19222162
14.

A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.

Hare S, Shun MC, Gupta SS, Valkov E, Engelman A, Cherepanov P.

PLoS Pathog. 2009 Jan;5(1):e1000259. doi: 10.1371/journal.ppat.1000259. Epub 2009 Jan 9.

15.

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.

McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M.

J Biol Chem. 2008 Nov 14;283(46):31802-12. doi: 10.1074/jbc.M805843200. Epub 2008 Sep 18.

16.

Comparative protein structure modeling using Modeller.

Eswar N, Webb B, Marti-Renom MA, Madhusudhan MS, Eramian D, Shen MY, Pieper U, Sali A.

Curr Protoc Bioinformatics. 2006 Oct;Chapter 5:Unit 5.6. doi: 10.1002/0471250953.bi0506s15.

17.

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

Engelman A, Cherepanov P.

PLoS Pathog. 2008 Mar 28;4(3):e1000046. doi: 10.1371/journal.ppat.1000046. Review.

18.

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro.

Botbol Y, Raghavendra NK, Rahman S, Engelman A, Lavigne M.

Nucleic Acids Res. 2008 Mar;36(4):1237-46. doi: 10.1093/nar/gkm1127. Epub 2008 Jan 3.

19.

Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding.

Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M.

J Biol Chem. 2008 Feb 29;283(9):5632-41. Epub 2007 Dec 19.

20.

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.

Shun MC, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, Cherepanov P, Engelman A.

Genes Dev. 2007 Jul 15;21(14):1767-78.

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