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Results: 1 to 20 of 50

1.

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E.

Genes Dev. 2011 Mar 1;25(5):460-70. doi: 10.1101/gad.2016311. Epub 2011 Feb 11.

PMID:
21317241
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Autophagy and metabolism.

Rabinowitz JD, White E.

Science. 2010 Dec 3;330(6009):1344-8. doi: 10.1126/science.1193497. Review.

PMID:
21127245
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis.

Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN.

N Engl J Med. 2010 Nov 4;363(19):1801-11. doi: 10.1056/NEJMoa1001671.

PMID:
21047224
[PubMed - indexed for MEDLINE]
Free Article
4.

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD.

Mol Cell. 2010 Jul 30;39(2):171-83. doi: 10.1016/j.molcel.2010.06.022.

PMID:
20670887
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Activation of autophagy during cell death requires the engulfment receptor Draper.

McPhee CK, Logan MA, Freeman MR, Baehrecke EH.

Nature. 2010 Jun 24;465(7301):1093-6. doi: 10.1038/nature09127.

PMID:
20577216
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Termination of autophagy and reformation of lysosomes regulated by mTOR.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ.

Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.

PMID:
20526321
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.

Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J.

Mol Cell. 2010 May 28;38(4):487-99. doi: 10.1016/j.molcel.2010.05.007.

PMID:
20513425
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Specific killing of Rb mutant cancer cells by inactivating TSC2.

Li B, Gordon GM, Du CH, Xu J, Du W.

Cancer Cell. 2010 May 18;17(5):469-80. doi: 10.1016/j.ccr.2010.03.019.

PMID:
20478529
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.

Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21.

PMID:
20173742
[PubMed - indexed for MEDLINE]
10.

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4153-8. doi: 10.1073/pnas.0913860107. Epub 2010 Feb 16. Erratum in: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8352.

PMID:
20160076
[PubMed - indexed for MEDLINE]
Free PMC Article
11.
12.

Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies.

Solomon VR, Lee H.

Eur J Pharmacol. 2009 Dec 25;625(1-3):220-33. doi: 10.1016/j.ejphar.2009.06.063. Epub 2009 Oct 15. Review.

PMID:
19836374
[PubMed - indexed for MEDLINE]
13.

mTOR signaling at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011. Review. No abstract available.

PMID:
19812304
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.

Pollizzi K, Malinowska-Kolodziej I, Stumm M, Lane H, Kwiatkowski D.

Mol Cancer. 2009 Jun 15;8:38. doi: 10.1186/1476-4598-8-38.

PMID:
19527517
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Autophagy suppresses tumorigenesis through elimination of p62.

Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E.

Cell. 2009 Jun 12;137(6):1062-75. doi: 10.1016/j.cell.2009.03.048. Erratum in: Cell. 2011 Apr 15;145(2):322.

PMID:
19524509
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy.

Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8923-8. doi: 10.1073/pnas.0903621106. Epub 2009 May 20.

PMID:
19458266
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Molecular mechanisms of mTOR-mediated translational control.

Ma XM, Blenis J.

Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. doi: 10.1038/nrm2672. Epub 2009 Apr 2. Review.

PMID:
19339977
[PubMed - indexed for MEDLINE]
18.

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.

Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X.

J Biol Chem. 2009 May 1;284(18):12297-305. doi: 10.1074/jbc.M900573200. Epub 2009 Mar 3.

PMID:
19258318
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation.

Chang YY, Neufeld TP.

Mol Biol Cell. 2009 Apr;20(7):2004-14. doi: 10.1091/mbc.E08-12-1250. Epub 2009 Feb 18.

PMID:
19225150
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N.

Mol Biol Cell. 2009 Apr;20(7):1981-91. doi: 10.1091/mbc.E08-12-1248. Epub 2009 Feb 11.

PMID:
19211835
[PubMed - indexed for MEDLINE]
Free PMC Article

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