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Results: 1 to 20 of 39

1.

The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.

Horiguchi M, Huang M, Meltzer HY.

J Pharmacol Exp Ther. 2011 Aug;338(2):605-14. doi: 10.1124/jpet.111.180638. Epub 2011 May 10.

PMID:
21558435
[PubMed - indexed for MEDLINE]
Free Article
2.

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.

Warne T, Moukhametzianov R, Baker JG, Nehmé R, Edwards PC, Leslie AG, Schertler GF, Tate CG.

Nature. 2011 Jan 13;469(7329):241-4. doi: 10.1038/nature09746.

PMID:
21228877
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK.

Nature. 2011 Jan 13;469(7329):236-40. doi: 10.1038/nature09665.

PMID:
21228876
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL.

Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3.

PMID:
21048700
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Strategies to discover unexpected targets for drugs active at G protein-coupled receptors.

Allen JA, Roth BL.

Annu Rev Pharmacol Toxicol. 2011;51:117-44. doi: 10.1146/annurev-pharmtox-010510-100553. Review.

PMID:
20868273
[PubMed - indexed for MEDLINE]
6.

Htr2a Gene and 5-HT(2A) Receptor Expression in the Cerebral Cortex Studied Using Genetically Modified Mice.

Weber ET, Andrade R.

Front Neurosci. 2010 Aug 13;4. pii: 36. doi: 10.3389/fnins.2010.00036. eCollection 2010.

PMID:
20802802
[PubMed]
Free PMC Article
7.

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.

Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, Pin JP, Anisman H, Ferguson SS.

Nat Neurosci. 2010 May;13(5):622-9. doi: 10.1038/nn.2529. Epub 2010 Apr 11.

PMID:
20383137
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Pimavanserin, a serotonin(2A) receptor inverse agonist, for the treatment of parkinson's disease psychosis.

Meltzer HY, Mills R, Revell S, Williams H, Johnson A, Bahr D, Friedman JH.

Neuropsychopharmacology. 2010 Mar;35(4):881-92. doi: 10.1038/npp.2009.176. Epub 2009 Nov 11.

PMID:
19907417
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.

Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL.

J Neurosci. 2009 Jun 3;29(22):7124-36. doi: 10.1523/JNEUROSCI.1090-09.2009.

PMID:
19494135
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.

Science. 2007 Nov 23;318(5854):1266-73. Epub 2007 Oct 25.

PMID:
17962519
[PubMed - indexed for MEDLINE]
Free Article
11.

The evasive nature of drug efficacy: implications for drug discovery.

Galandrin S, Oligny-Longpré G, Bouvier M.

Trends Pharmacol Sci. 2007 Aug;28(8):423-30. Epub 2007 Jul 19. Review.

PMID:
17659355
[PubMed - indexed for MEDLINE]
12.

Functional selectivity and classical concepts of quantitative pharmacology.

Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB.

J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. Epub 2006 Jun 27. Review.

PMID:
16803859
[PubMed - indexed for MEDLINE]
Free Article
13.

Finding new tricks for old drugs: an efficient route for public-sector drug discovery.

O'Connor KA, Roth BL.

Nat Rev Drug Discov. 2005 Dec;4(12):1005-14. Review.

PMID:
16341065
[PubMed - indexed for MEDLINE]
14.

The human polyomavirus, JCV, uses serotonin receptors to infect cells.

Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A, Kroeze WK, Roth BL, Atwood WJ.

Science. 2004 Nov 19;306(5700):1380-3.

PMID:
15550673
[PubMed - indexed for MEDLINE]
Free Article
15.

Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder.

Meltzer HY, Arvanitis L, Bauer D, Rein W; Meta-Trial Study Group.

Am J Psychiatry. 2004 Jun;161(6):975-84.

PMID:
15169685
[PubMed - indexed for MEDLINE]
16.

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.

Roth BL, Sheffler DJ, Kroeze WK.

Nat Rev Drug Discov. 2004 Apr;3(4):353-9. Review. No abstract available.

PMID:
15060530
[PubMed - indexed for MEDLINE]
17.

Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.

Harvey JA, Quinn JL, Liu R, Aloyo VJ, Romano AG.

Psychopharmacology (Berl). 2004 Apr;172(4):435-42. Epub 2003 Dec 17.

PMID:
14685644
[PubMed - indexed for MEDLINE]
18.

The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.

Xia Z, Hufeisen SJ, Gray JA, Roth BL.

Neuroscience. 2003;122(4):907-20.

PMID:
14643760
[PubMed - indexed for MEDLINE]
19.

A modification of receptor theory.

STEPHENSON RP.

Br J Pharmacol Chemother. 1956 Dec;11(4):379-93. No abstract available.

PMID:
13383117
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor.

Hanley NR, Hensler JG.

J Pharmacol Exp Ther. 2002 Feb;300(2):468-77.

PMID:
11805206
[PubMed - indexed for MEDLINE]
Free Article

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