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Items: 1 to 20 of 52

1.

Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.

Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K.

Mol Cell Biol. 2011 Apr;31(8):1719-33. doi: 10.1128/MCB.01298-10. Epub 2011 Feb 7.

2.

Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability.

Nagasawa H, Little JB, Lin YF, So S, Kurimasa A, Peng Y, Brogan JR, Chen DJ, Bedford JS, Chen BP.

Radiat Res. 2011 Jan;175(1):83-9. doi: 10.1667/RR2092.1. Epub 2010 Nov 17.

3.

Autophosphorylation and ATM activation: additional sites add to the complexity.

Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF.

J Biol Chem. 2011 Mar 18;286(11):9107-19. doi: 10.1074/jbc.M110.204065. Epub 2010 Dec 13.

4.

Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.

Yu DS, Zhao R, Hsu EL, Cayer J, Ye F, Guo Y, Shyr Y, Cortez D.

EMBO Rep. 2010 Nov;11(11):876-82. doi: 10.1038/embor.2010.153. Epub 2010 Oct 8.

5.

Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.

Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13660-5. doi: 10.1073/pnas.1007856107. Epub 2010 Jun 28.

6.

The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.

Navadgi-Patil VM, Burgers PM.

Mol Cell. 2009 Dec 11;36(5):743-53. doi: 10.1016/j.molcel.2009.10.014.

7.

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.

Bansbach CE, Bétous R, Lovejoy CA, Glick GG, Cortez D.

Genes Dev. 2009 Oct 15;23(20):2405-14. doi: 10.1101/gad.1839909. Epub 2009 Sep 30.

8.

ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.

Zighelboim I, Schmidt AP, Gao F, Thaker PH, Powell MA, Rader JS, Gibb RK, Mutch DG, Goodfellow PJ.

J Clin Oncol. 2009 Jul 1;27(19):3091-6. doi: 10.1200/JCO.2008.19.9802. Epub 2009 May 26. Erratum in: J Clin Oncol. 2009 Oct 1;27(28):4819.

9.

Common mechanisms of PIKK regulation.

Lovejoy CA, Cortez D.

DNA Repair (Amst). 2009 Sep 2;8(9):1004-8. doi: 10.1016/j.dnarep.2009.04.006. Epub 2009 May 21. Review.

10.

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D.

Mol Cell Biol. 2008 Dec;28(24):7345-53. doi: 10.1128/MCB.01079-08. Epub 2008 Oct 20.

11.

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.

Zabludoff SD, Deng C, Grondine MR, Sheehy AM, Ashwell S, Caleb BL, Green S, Haye HR, Horn CL, Janetka JW, Liu D, Mouchet E, Ready S, Rosenthal JL, Queva C, Schwartz GK, Taylor KJ, Tse AN, Walker GE, White AM.

Mol Cancer Ther. 2008 Sep;7(9):2955-66. doi: 10.1158/1535-7163.MCT-08-0492.

12.

Activation of ATR and related PIKKs.

Mordes DA, Cortez D.

Cell Cycle. 2008 Sep 15;7(18):2809-12. Epub 2008 Sep 30.

13.

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M.

Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007.

14.

A quantitative atlas of mitotic phosphorylation.

Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.

15.

ATR: an essential regulator of genome integrity.

Cimprich KA, Cortez D.

Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27. doi: 10.1038/nrm2450. Epub 2008 Jul 2. Review.

16.

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

Mordes DA, Glick GG, Zhao R, Cortez D.

Genes Dev. 2008 Jun 1;22(11):1478-89. doi: 10.1101/gad.1666208.

17.

Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers.

Lewis KA, Bakkum-Gamez J, Loewen R, French AJ, Thibodeau SN, Cliby WA.

Genes Chromosomes Cancer. 2007 Dec;46(12):1061-8.

PMID:
17879369
18.
19.

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

Lee J, Kumagai A, Dunphy WG.

J Biol Chem. 2007 Sep 21;282(38):28036-44. Epub 2007 Jul 18.

20.

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM.

Genes Dev. 2007 Jun 15;21(12):1472-7.

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