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Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes.

Schrempf W, Eulitz M, Neumeister V, Siegert G, Koch R, Reichmann H, Storch A.

J Neurol. 2011 Mar;258(3):393-401. doi: 10.1007/s00415-010-5764-4. Epub 2010 Oct 2.


Transcobalamin deficiency caused by compound heterozygosity for two novel mutations in the TCN2 gene: a study of two affected siblings, their brother, and their parents.

Nissen PH, Nordwall M, Hoffmann-Lücke E, Sorensen BS, Nexo E.

J Inherit Metab Dis. 2010 Dec;33 Suppl 3:S269-74. doi: 10.1007/s10545-010-9145-z. Epub 2010 Jul 6.


Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics.

Garrod MG, Allen LH, Haan MN, Green R, Miller JW.

Eur J Clin Nutr. 2010 May;64(5):503-9. doi: 10.1038/ejcn.2010.20. Epub 2010 Mar 10.


The TCN2 776CNG polymorphism correlates with vitamin B(12) cellular delivery in healthy adult populations.

Castro R, Barroso M, Rocha M, Esse R, Ramos R, Ravasco P, Rivera I, de Almeida IT.

Clin Biochem. 2010 May;43(7-8):645-9. doi: 10.1016/j.clinbiochem.2010.01.015. Epub 2010 Feb 6.


Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population.

Bor MV, von Castel-Roberts KM, Kauwell GP, Stabler SP, Allen RH, Maneval DR, Bailey LB, Nexo E.

Am J Clin Nutr. 2010 Mar;91(3):571-7. doi: 10.3945/ajcn.2009.28082. Epub 2010 Jan 13.


Metabolic signs of vitamin B(12) deficiency in humans: computational model and its implications for diagnostics.

Fedosov SN.

Metabolism. 2010 Aug;59(8):1124-38. doi: 10.1016/j.metabol.2009.09.036. Epub 2010 Jan 6.


Assessment of vitamin B(12) absorption based on the accumulation of orally administered cyanocobalamin on transcobalamin.

Hardlei TF, Mørkbak AL, Bor MV, Bailey LB, Hvas AM, Nexo E.

Clin Chem. 2010 Mar;56(3):432-6. doi: 10.1373/clinchem.2009.131524. Epub 2009 Dec 29.


Determination of serum holotranscobalamin concentrations with the AxSYM active B(12) assay: cut-off point evaluation in the clinical laboratory.

Bamonti F, Moscato GA, Novembrino C, Gregori D, Novi C, De Giuseppe R, Galli C, Uva V, Lonati S, Maiavacca R.

Clin Chem Lab Med. 2010 Feb;48(2):249-53. doi: 10.1515/CCLM.2010.032.


A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrin.

Hardlei TF, Nexo E.

Clin Chem. 2009 May;55(5):1002-10. doi: 10.1373/clinchem.2008.114132. Epub 2009 Mar 19.


The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin.

Quadros EV, Nakayama Y, Sequeira JM.

Blood. 2009 Jan 1;113(1):186-92. doi: 10.1182/blood-2008-05-158949. Epub 2008 Sep 8.


Active B12: a rapid, automated assay for holotranscobalamin on the Abbott AxSYM analyzer.

Brady J, Wilson L, McGregor L, Valente E, Orning L.

Clin Chem. 2008 Mar;54(3):567-73. doi: 10.1373/clinchem.2007.096784. Epub 2008 Jan 4.


Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring.

Murphy MM, Molloy AM, Ueland PM, Fernandez-Ballart JD, Schneede J, Arija V, Scott JM.

J Nutr. 2007 Aug;137(8):1863-7.


Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status.

von Castel-Roberts KM, Morkbak AL, Nexo E, Edgemon CA, Maneval DR, Shuster JJ, Valentine JF, Kauwell GP, Bailey LB.

Am J Clin Nutr. 2007 Apr;85(4):1057-61.


Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.

Clarke R, Sherliker P, Hin H, Nexo E, Hvas AM, Schneede J, Birks J, Ueland PM, Emmens K, Scott JM, Molloy AM, Evans JG.

Clin Chem. 2007 May;53(5):963-70. Epub 2007 Mar 15.


Holotranscobalamin and methylmalonic acid as prognostic markers following an acute myocardial infarction.

Aarsetøy H, Valente E, Reine A, Mansoor MA, Grundt H, Nilsen DW.

Eur J Clin Nutr. 2008 Mar;62(3):411-8. Epub 2007 Mar 7.


Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged.

Loikas S, Koskinen P, Irjala K, Löppönen M, Isoaho R, Kivelä SL, Pelliniemi TT.

Clin Chem Lab Med. 2007;45(2):197-201.


Diagnosis and treatment of vitamin B12 deficiency--an update.

Hvas AM, Nexo E.

Haematologica. 2006 Nov;91(11):1506-12. Epub 2006 Oct 17. Review.

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