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Results: 1 to 20 of 46

1.

Relevant anion-π interactions in biological systems: the case of urate oxidase.

Estarellas C, Frontera A, Quiñonero D, Deyà PM.

Angew Chem Int Ed Engl. 2011 Jan 10;50(2):415-8. doi: 10.1002/anie.201005635. No abstract available.

PMID:
21132687
[PubMed - indexed for MEDLINE]
2.

Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF.

Antimicrob Agents Chemother. 2010 Sep;54(9):3913-21. doi: 10.1128/AAC.00434-10. Epub 2010 Jun 14.

PMID:
20547794
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.

Su HP, Yan Y, Prasad GS, Smith RF, Daniels CL, Abeywickrema PD, Reid JC, Loughran HM, Kornienko M, Sharma S, Grobler JA, Xu B, Sardana V, Allison TJ, Williams PD, Darke PL, Hazuda DJ, Munshi S.

J Virol. 2010 Aug;84(15):7625-33. doi: 10.1128/JVI.00353-10. Epub 2010 May 19.

PMID:
20484498
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E.

Structure. 2009 Dec 9;17(12):1625-35. doi: 10.1016/j.str.2009.09.016.

PMID:
20004166
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Small molecule inhibitors of HIV RT Ribonuclease H.

Di Grandi M, Olson M, Prashad AS, Bebernitz G, Luckay A, Mullen S, Hu Y, Krishnamurthy G, Pitts K, O'Connell J.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):398-402. doi: 10.1016/j.bmcl.2009.10.043. Epub 2009 Oct 15.

PMID:
19939680
[PubMed - indexed for MEDLINE]
6.

RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.

Kirschberg TA, Balakrishnan M, Squires NH, Barnes T, Brendza KM, Chen X, Eisenberg EJ, Jin W, Kutty N, Leavitt S, Liclican A, Liu Q, Liu X, Mak J, Perry JK, Wang M, Watkins WJ, Lansdon EB.

J Med Chem. 2009 Oct 8;52(19):5781-4. doi: 10.1021/jm900597q.

PMID:
19791799
[PubMed - indexed for MEDLINE]
7.

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.

Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S.

ACS Chem Biol. 2008 Oct 17;3(10):635-44. doi: 10.1021/cb8001039. Epub 2008 Oct 3.

PMID:
18831589
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.

Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD Jr, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E.

Nucleic Acids Res. 2008 Sep;36(15):5083-92. doi: 10.1093/nar/gkn464. Epub 2008 Aug 1.

PMID:
18676450
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.

Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71. doi: 10.1073/pnas.0711209105. Epub 2008 Jan 29.

PMID:
18230722
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Anion-pi interactions.

Schottel BL, Chifotides HT, Dunbar KR.

Chem Soc Rev. 2008 Jan;37(1):68-83. doi: 10.1039/b614208g. Epub 2007 Sep 12. Review. Erratum in: Chem Soc Rev. 2008 Jan;37(1):233.

PMID:
18197334
[PubMed - indexed for MEDLINE]
11.

Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.

Marchand C, Beutler JA, Wamiru A, Budihas S, Möllmann U, Heinisch L, Mellors JW, Le Grice SF, Pommier Y.

Antimicrob Agents Chemother. 2008 Jan;52(1):361-4. Epub 2007 Oct 29.

PMID:
17967911
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.

Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB.

J Nat Prod. 2007 Oct;70(10):1647-9. Epub 2007 Oct 13.

PMID:
17935297
[PubMed - indexed for MEDLINE]
13.

Geometry of nonbonded interactions involving planar groups in proteins.

Chakrabarti P, Bhattacharyya R.

Prog Biophys Mol Biol. 2007 Sep-Nov;95(1-3):83-137. Epub 2007 Jun 5. Review.

PMID:
17629549
[PubMed - indexed for MEDLINE]
14.

A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.

Dat NT, Bae K, Wamiru A, McMahon JB, Le Grice SF, Bona M, Beutler JA, Kim YH.

J Nat Prod. 2007 May;70(5):839-41. Epub 2007 Mar 31.

PMID:
17397219
[PubMed - indexed for MEDLINE]
15.

HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.

Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD Jr, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E.

ACS Chem Biol. 2006 Dec 20;1(11):702-12.

PMID:
17184135
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Hang JQ, Li Y, Yang Y, Cammack N, Mirzadegan T, Klumpp K.

Biochem Biophys Res Commun. 2007 Jan 12;352(2):341-50. Epub 2006 Nov 14.

PMID:
17113568
[PubMed - indexed for MEDLINE]
17.

Recent progress in the design of small molecule inhibitors of HIV RNase H.

Klumpp K, Mirzadegan T.

Curr Pharm Des. 2006;12(15):1909-22. Review.

PMID:
16724956
[PubMed - indexed for MEDLINE]
18.

Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors.

Boone LR.

Curr Opin Investig Drugs. 2006 Feb;7(2):128-35. Review.

PMID:
16499282
[PubMed - indexed for MEDLINE]
19.

Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.

Didierjean J, Isel C, Querré F, Mouscadet JF, Aubertin AM, Valnot JY, Piettre SR, Marquet R.

Antimicrob Agents Chemother. 2005 Dec;49(12):4884-94.

PMID:
16304149
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.

Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA, Crouch RJ, McMahon JB, Beutler JA, Le Grice SF.

Nucleic Acids Res. 2005 Mar 1;33(4):1249-56. Print 2005.

PMID:
15741178
[PubMed - indexed for MEDLINE]
Free PMC Article
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