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Results: 1 to 20 of 32

1.

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1.

Tefferi A.

Leukemia. 2010 Jun;24(6):1128-38. doi: 10.1038/leu.2010.69. Epub 2010 Apr 29. Review.

PMID:
20428194
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

Challen GA, Boles NC, Chambers SM, Goodell MA.

Cell Stem Cell. 2010 Mar 5;6(3):265-78. doi: 10.1016/j.stem.2010.02.002.

PMID:
20207229
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.

Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F.

PLoS One. 2010 Feb 18;5(2):e9258. doi: 10.1371/journal.pone.0009258.

PMID:
20174635
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.

Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, Lipp M, Ibrahim S, Efstratiadis A, Zagzag D, Bromberg JS, Dustin ML, Aifantis I.

Nature. 2009 Jun 18;459(7249):1000-4. doi: 10.1038/nature08020.

PMID:
19536265
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E.

Cancer Cell. 2009 Apr 7;15(4):341-52. doi: 10.1016/j.ccr.2009.02.016.

PMID:
19345332
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells.

Ng SY, Yoshida T, Zhang J, Georgopoulos K.

Immunity. 2009 Apr 17;30(4):493-507. doi: 10.1016/j.immuni.2009.01.014. Epub 2009 Apr 2.

PMID:
19345118
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.

Van de Walle I, De Smet G, De Smedt M, Vandekerckhove B, Leclercq G, Plum J, Taghon T.

Blood. 2009 Mar 26;113(13):2988-98. doi: 10.1182/blood-2008-06-164871. Epub 2008 Dec 3.

PMID:
19056690
[PubMed - indexed for MEDLINE]
Free Article
8.

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.

Taghon T, Van de Walle I, De Smet G, De Smedt M, Leclercq G, Vandekerckhove B, Plum J.

Blood. 2009 Apr 2;113(14):3254-63. doi: 10.1182/blood-2008-07-168906. Epub 2008 Oct 23.

PMID:
18948571
[PubMed - indexed for MEDLINE]
Free Article
9.

Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I, Pear WS, Aster JC, Gilliland DG.

Cell Stem Cell. 2008 Sep 11;3(3):314-26. doi: 10.1016/j.stem.2008.07.010.

PMID:
18786418
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia.

Emanuel PD.

Leukemia. 2008 Jul;22(7):1335-42. doi: 10.1038/leu.2008.162. Epub 2008 Jun 12. Review.

PMID:
18548091
[PubMed - indexed for MEDLINE]
11.

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

Robert-Moreno A, Guiu J, Ruiz-Herguido C, López ME, Inglés-Esteve J, Riera L, Tipping A, Enver T, Dzierzak E, Gridley T, Espinosa L, Bigas A.

EMBO J. 2008 Jul 9;27(13):1886-95. doi: 10.1038/emboj.2008.113. Epub 2008 Jun 5.

PMID:
18528438
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.

Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R.

PLoS Biol. 2008 May 27;6(5):e123. doi: 10.1371/journal.pbio.0060123.

PMID:
18507503
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.

Thompson BJ, Jankovic V, Gao J, Buonamici S, Vest A, Lee JM, Zavadil J, Nimer SD, Aifantis I.

J Exp Med. 2008 Jun 9;205(6):1395-408. doi: 10.1084/jem.20080277. Epub 2008 May 12.

PMID:
18474632
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Molecular pathogenesis of T-cell leukaemia and lymphoma.

Aifantis I, Raetz E, Buonamici S.

Nat Rev Immunol. 2008 May;8(5):380-90. doi: 10.1038/nri2304. Review.

PMID:
18421304
[PubMed - indexed for MEDLINE]
15.

Crossing paths with Notch in the hyper-network.

Hurlbut GD, Kankel MW, Lake RJ, Artavanis-Tsakonas S.

Curr Opin Cell Biol. 2007 Apr;19(2):166-75. Epub 2007 Feb 20. Review.

PMID:
17317139
[PubMed - indexed for MEDLINE]
16.

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA.

Nature. 2006 Aug 17;442(7104):818-22. Epub 2006 Jul 16.

PMID:
16862118
[PubMed - indexed for MEDLINE]
17.

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.

Grabher C, von Boehmer H, Look AT.

Nat Rev Cancer. 2006 May;6(5):347-59. Review.

PMID:
16612405
[PubMed - indexed for MEDLINE]
18.

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. Epub 2005 Sep 30.

PMID:
16199517
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Nicastrin: gatekeeper of the gamma-secretase complex.

De Strooper B.

Cell. 2005 Aug 12;122(3):318-20. Review.

PMID:
16096051
[PubMed - indexed for MEDLINE]
Free Article
20.

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

Taghon TN, David ES, Zúñiga-Pflücker JC, Rothenberg EV.

Genes Dev. 2005 Apr 15;19(8):965-78.

PMID:
15833919
[PubMed - indexed for MEDLINE]
Free PMC Article

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