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CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T, Boulton SJ.

Mol Cell. 2010 Sep 24;39(6):839-50. doi: 10.1016/j.molcel.2010.08.037.


A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

Hurov KE, Cotta-Ramusino C, Elledge SJ.

Genes Dev. 2010 Sep 1;24(17):1939-50. doi: 10.1101/gad.1934210.


Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

Takai H, Xie Y, de Lange T, Pavletich NP.

Genes Dev. 2010 Sep 15;24(18):2019-30. doi: 10.1101/gad.1956410. Epub 2010 Aug 27.


A global protein kinase and phosphatase interaction network in yeast.

Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, Larsen B, Lin ZY, Breitkreutz BJ, Stark C, Liu G, Ahn J, Dewar-Darch D, Reguly T, Tang X, Almeida R, Qin ZS, Pawson T, Gingras AC, Nesvizhskii AI, Tyers M.

Science. 2010 May 21;328(5981):1043-6. doi: 10.1126/science.1176495.


Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N.

J Biol Chem. 2010 Jun 25;285(26):20109-16. doi: 10.1074/jbc.M110.121699. Epub 2010 Apr 28.


AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

Izumi N, Yamashita A, Iwamatsu A, Kurata R, Nakamura H, Saari B, Hirano H, Anderson P, Ohno S.

Sci Signal. 2010 Apr 6;3(116):ra27. doi: 10.1126/scisignal.2000468.


Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.

Ben-Aroya S, Agmon N, Yuen K, Kwok T, McManus K, Kupiec M, Hieter P.

PLoS Genet. 2010 Feb 19;6(2):e1000852. doi: 10.1371/journal.pgen.1000852.


Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes.

Huen J, Kakihara Y, Ugwu F, Cheung KL, Ortega J, Houry WA.

Biochem Cell Biol. 2010 Feb;88(1):29-40. doi: 10.1139/o09-122. Review.


Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Schvartzman JM, Sotillo R, Benezra R.

Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781. Review.


The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C.

Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.


COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer.

Forbes SA, Tang G, Bindal N, Bamford S, Dawson E, Cole C, Kok CY, Jia M, Ewing R, Menzies A, Teague JW, Stratton MR, Futreal PA.

Nucleic Acids Res. 2010 Jan;38(Database issue):D652-7. doi: 10.1093/nar/gkp995. Epub 2009 Nov 11.


A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms.

Carroll SY, Stirling PC, Stimpson HE, Giesselmann E, Schmitt MJ, Drubin DG.

Dev Cell. 2009 Oct;17(4):552-60. doi: 10.1016/j.devcel.2009.08.006.


Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.

McLellan J, O'Neil N, Tarailo S, Stoepel J, Bryan J, Rose A, Hieter P.

Mol Biol Cell. 2009 Dec;20(24):5306-13. doi: 10.1091/mbc.E09-08-0699. Epub .


A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.

Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA.

Mol Cell. 2009 Jul 31;35(2):228-39. doi: 10.1016/j.molcel.2009.06.021.


Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect.

Veatch JR, McMurray MA, Nelson ZW, Gottschling DE.

Cell. 2009 Jun 26;137(7):1247-58. doi: 10.1016/j.cell.2009.04.014.


Nutrient control of TORC1, a cell-cycle regulator.

Wang X, Proud CG.

Trends Cell Biol. 2009 Jun;19(6):260-7. doi: 10.1016/j.tcb.2009.03.005. Epub 2009 May 4. Review.


A genome-wide screen for essential yeast genes that affect telomere length maintenance.

Ungar L, Yosef N, Sela Y, Sharan R, Ruppin E, Kupiec M.

Nucleic Acids Res. 2009 Jul;37(12):3840-9. doi: 10.1093/nar/gkp259. Epub 2009 Apr 22.


Formalin can alter the intracellular localization of some transcription factors in Saccharomyces cerevisiae.

Tate JJ, Cooper TG.

FEMS Yeast Res. 2008 Dec;8(8):1223-35. doi: 10.1111/j.1567-1364.2008.00441.x.


Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Shevchenko A, Roguev A, Schaft D, Buchanan L, Habermann B, Sakalar C, Thomas H, Krogan NJ, Shevchenko A, Stewart AF.

Genome Biol. 2008;9(11):R167. doi: 10.1186/gb-2008-9-11-r167. Epub 2008 Nov 28.


A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS.

Nat Methods. 2008 Aug;5(8):711-8. doi: 10.1038/nmeth.1234. Epub 2008 Jul 11.

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