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Results: 1 to 20 of 50

1.

Structure of the minimal interface between ApoE and LRP.

Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA.

J Mol Biol. 2010 Apr 30;398(2):306-19. doi: 10.1016/j.jmb.2010.03.022. Epub 2010 Mar 19.

PMID:
20303980
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.

Guttman M, Prieto JH, Croy JE, Komives EA.

Biochemistry. 2010 Feb 16;49(6):1207-16. doi: 10.1021/bi9017208.

PMID:
20030366
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor.

Huang S, Henry L, Ho YK, Pownall HJ, Rudenko G.

J Lipid Res. 2010 Feb;51(2):297-308. doi: 10.1194/jlr.M000422. Epub 2009 Aug 11.

PMID:
19674976
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The role of calcium in lipoprotein release by the low-density lipoprotein receptor.

Zhao Z, Michaely P.

Biochemistry. 2009 Aug 4;48(30):7313-24. doi: 10.1021/bi900214u.

PMID:
19583244
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Domain swapping reveals that low density lipoprotein (LDL) type A repeat order affects ligand binding to the LDL receptor.

Yamamoto T, Ryan RO.

J Biol Chem. 2009 May 15;284(20):13396-400. doi: 10.1074/jbc.M900194200. Epub 2009 Mar 26.

PMID:
19329437
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells.

McNutt MC, Kwon HJ, Chen C, Chen JR, Horton JD, Lagace TA.

J Biol Chem. 2009 Apr 17;284(16):10561-70. doi: 10.1074/jbc.M808802200. Epub 2009 Feb 17.

PMID:
19224862
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586.

Zhao Z, Michaely P.

J Biol Chem. 2008 Sep 26;283(39):26528-37. doi: 10.1074/jbc.M804624200. Epub 2008 Aug 3.

PMID:
18677035
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.

Arias-Moreno X, Velazquez-Campoy A, Rodríguez JC, Pocoví M, Sancho J.

J Biol Chem. 2008 Aug 15;283(33):22670-9. doi: 10.1074/jbc.M802153200. Epub 2008 Jun 23.

PMID:
18574243
[PubMed - indexed for MEDLINE]
Free Article
9.

Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes.

Saito M, Hanson PI, Schlesinger P.

J Biol Chem. 2007 Sep 14;282(37):27327-33. Epub 2007 Jul 3.

PMID:
17609211
[PubMed - indexed for MEDLINE]
Free Article
10.

Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.

Michaely P, Zhao Z, Li WP, Garuti R, Huang LJ, Hobbs HH, Cohen JC.

EMBO J. 2007 Jul 25;26(14):3273-82. Epub 2007 Jun 21.

PMID:
17581630
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Diagnosis of families with familial hypercholesterolaemia and/or Apo B-100 defect by means of DNA analysis of LDL-receptor gene mutations.

Widhalm K, Dirisamer A, Lindemayr A, Kostner G.

J Inherit Metab Dis. 2007 Apr;30(2):239-47. Epub 2007 Mar 8.

PMID:
17347910
[PubMed - indexed for MEDLINE]
12.

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.

Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD.

J Clin Invest. 2006 Nov;116(11):2995-3005.

PMID:
17080197
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine.

Peters-Libeu CA, Newhouse Y, Hatters DM, Weisgraber KH.

J Biol Chem. 2006 Jan 13;281(2):1073-9. Epub 2005 Nov 8.

PMID:
16278220
[PubMed - indexed for MEDLINE]
Free Article
14.

Low density lipoprotein--receptor (LDL-R) gene mutations among Filipinos with familial hypercholesterolemia.

Punzalan FE, Sy RG, Santos RS, Cutiongco EM, Gosiengfiao S, Fadriguilan E, George P, Laurie A.

J Atheroscler Thromb. 2005;12(5):276-83.

PMID:
16205024
[PubMed - indexed for MEDLINE]
Free Article
15.

Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions.

Abdul-Aziz D, Fisher C, Beglova N, Blacklow SC.

Biochemistry. 2005 Apr 5;44(13):5075-85.

PMID:
15794645
[PubMed - indexed for MEDLINE]
16.

Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor.

Beglova N, Jeon H, Fisher C, Blacklow SC.

Mol Cell. 2004 Oct 22;16(2):281-92.

PMID:
15494314
[PubMed - indexed for MEDLINE]
17.

A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands.

Fisher C, Abdul-Aziz D, Blacklow SC.

Biochemistry. 2004 Feb 3;43(4):1037-44.

PMID:
14744149
[PubMed - indexed for MEDLINE]
18.

Structure of the LDL receptor extracellular domain at endosomal pH.

Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J.

Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29.

PMID:
12459547
[PubMed - indexed for MEDLINE]
Free Article
19.

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery.

Mishra SK, Watkins SC, Traub LM.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16099-104. Epub 2002 Nov 25.

PMID:
12451172
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Intronic mutations outside of Alu-repeat-rich domains of the LDL receptor gene are a cause of familial hypercholesterolemia.

Amsellem S, Briffaut D, Carrié A, Rabès JP, Girardet JP, Fredenrich A, Moulin P, Krempf M, Reznik Y, Vialettes B, de Gennes JL, Brukert E, Benlian P.

Hum Genet. 2002 Dec;111(6):501-10. Epub 2002 Sep 13.

PMID:
12436241
[PubMed - indexed for MEDLINE]
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