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Results: 1 to 20 of 77

1.

New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.

Rai R, Deval J.

Antiviral Res. 2011 May;90(2):93-101. doi: 10.1016/j.antiviral.2011.01.009. Epub 2011 Feb 2. Review.

PMID:
21295075
[PubMed - indexed for MEDLINE]
2.

Consensus motif for integrin transmembrane helix association.

Berger BW, Kulp DW, Span LM, DeGrado JL, Billings PC, Senes A, Bennett JS, DeGrado WF.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):703-8. doi: 10.1073/pnas.0910873107. Epub 2009 Dec 18.

PMID:
20080739
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Endocytic Rab proteins are required for hepatitis C virus replication complex formation.

Manna D, Aligo J, Xu C, Park WS, Koc H, Heo WD, Konan KV.

Virology. 2010 Mar 1;398(1):21-37. doi: 10.1016/j.virol.2009.11.034. Epub 2009 Dec 16.

PMID:
20005553
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein.

Aligo J, Jia S, Manna D, Konan KV.

Virology. 2009 Oct 10;393(1):68-83. doi: 10.1016/j.virol.2009.07.033. Epub 2009 Aug 22.

PMID:
19703698
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association.

Gouttenoire J, Montserret R, Kennel A, Penin F, Moradpour D.

J Virol. 2009 Nov;83(21):11378-84. doi: 10.1128/JVI.01122-09. Epub 2009 Aug 19.

PMID:
19692468
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Compensatory mutations in NS3 and NS5A proteins enhance the virus production capability of hepatitis C reporter virus.

Han Q, Xu C, Wu C, Zhu W, Yang R, Chen X.

Virus Res. 2009 Oct;145(1):63-73. doi: 10.1016/j.virusres.2009.06.005. Epub 2009 Jun 18.

PMID:
19540283
[PubMed - indexed for MEDLINE]
7.

Interaction and conformational dynamics of membrane-spanning protein helices.

Langosch D, Arkin IT.

Protein Sci. 2009 Jul;18(7):1343-58. doi: 10.1002/pro.154. Review.

PMID:
19530249
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations.

Pietschmann T, Zayas M, Meuleman P, Long G, Appel N, Koutsoudakis G, Kallis S, Leroux-Roels G, Lohmann V, Bartenschlager R.

PLoS Pathog. 2009 Jun;5(6):e1000475. doi: 10.1371/journal.ppat.1000475. Epub 2009 Jun 12.

PMID:
19521536
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain.

Liefhebber JM, Brandt BW, Broer R, Spaan WJ, van Leeuwen HC.

Virol J. 2009 May 25;6:62. doi: 10.1186/1743-422X-6-62.

PMID:
19467155
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.

Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA.

Mol Cell. 2009 Apr 24;34(2):234-49. doi: 10.1016/j.molcel.2009.02.022.

PMID:
19394300
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B.

Gouttenoire J, Castet V, Montserret R, Arora N, Raussens V, Ruysschaert JM, Diesis E, Blum HE, Penin F, Moradpour D.

J Virol. 2009 Jun;83(12):6257-68. doi: 10.1128/JVI.02663-08. Epub 2009 Apr 8.

PMID:
19357161
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity.

Thompson AA, Zou A, Yan J, Duggal R, Hao W, Molina D, Cronin CN, Wells PA.

Biochemistry. 2009 Feb 10;48(5):906-16. doi: 10.1021/bi801747p.

PMID:
19146391
[PubMed - indexed for MEDLINE]
13.

The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus.

Jones DM, Patel AH, Targett-Adams P, McLauchlan J.

J Virol. 2009 Mar;83(5):2163-77. doi: 10.1128/JVI.01885-08. Epub 2008 Dec 10.

PMID:
19073716
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.

Nat Biotechnol. 2008 Sep;26(9):1019-27. doi: 10.1038/nbt.1490.

PMID:
18758449
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A genetic interaction between hepatitis C virus NS4B and NS3 is important for RNA replication.

Paredes AM, Blight KJ.

J Virol. 2008 Nov;82(21):10671-83. doi: 10.1128/JVI.00875-08. Epub 2008 Aug 20.

PMID:
18715921
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.

Masaki T, Suzuki R, Murakami K, Aizaki H, Ishii K, Murayama A, Date T, Matsuura Y, Miyamura T, Wakita T, Suzuki T.

J Virol. 2008 Aug;82(16):7964-76. doi: 10.1128/JVI.00826-08. Epub 2008 Jun 4.

PMID:
18524832
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly.

Ma Y, Yates J, Liang Y, Lemon SM, Yi M.

J Virol. 2008 Aug;82(15):7624-39. doi: 10.1128/JVI.00724-08. Epub 2008 May 28.

PMID:
18508894
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Comparative protein structure modeling using MODELLER.

Eswar N, Webb B, Marti-Renom MA, Madhusudhan MS, Eramian D, Shen MY, Pieper U, Sali A.

Curr Protoc Protein Sci. 2007 Nov;Chapter 2:Unit 2.9. doi: 10.1002/0471140864.ps0209s50.

PMID:
18429317
[PubMed - indexed for MEDLINE]
19.

Comparative protein structure modeling using Modeller.

Eswar N, Webb B, Marti-Renom MA, Madhusudhan MS, Eramian D, Shen MY, Pieper U, Sali A.

Curr Protoc Bioinformatics. 2006 Oct;Chapter 5:Unit 5.6. doi: 10.1002/0471250953.bi0506s15.

PMID:
18428767
[PubMed - indexed for MEDLINE]
20.

Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.

Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R.

PLoS Pathog. 2008 Mar 28;4(3):e1000035. doi: 10.1371/journal.ppat.1000035.

PMID:
18369481
[PubMed - indexed for MEDLINE]
Free PMC Article

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