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Results: 1 to 20 of 32

1.

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD 4th, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, Wei J, Young DW, Akella LB, Ross NT, Zhang YL, Fass DM, Reis SA, Zhao WN, Haggarty SJ, Palmer M, Foley MA.

J Am Chem Soc. 2010 Dec 1;132(47):16962-76. doi: 10.1021/ja105119r. Epub 2010 Nov 10.

PMID:
21067169
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Stereochemical and skeletal diversity arising from amino propargylic alcohols.

Pizzirani D, Kaya T, Clemons PA, Schreiber SL.

Org Lett. 2010 Jun 18;12(12):2822-5. doi: 10.1021/ol100914b.

PMID:
20481457
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Cheminformatics approaches to analyze diversity in compound screening libraries.

Akella LB, DeCaprio D.

Curr Opin Chem Biol. 2010 Jun;14(3):325-30. doi: 10.1016/j.cbpa.2010.03.017. Epub 2010 Apr 22. Review.

PMID:
20457001
[PubMed - indexed for MEDLINE]
4.

Synthesis and applications of tert-butanesulfinamide.

Robak MT, Herbage MA, Ellman JA.

Chem Rev. 2010 Jun 9;110(6):3600-740. doi: 10.1021/cr900382t. Review. No abstract available.

PMID:
20420386
[PubMed - indexed for MEDLINE]
5.

Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.

Rolfe A, Lushington GH, Hanson PR.

Org Biomol Chem. 2010 May 7;8(9):2198-203. doi: 10.1039/b927161a. Epub 2010 Mar 16.

PMID:
20401396
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.

Bauer RA, DiBlasi CM, Tan DS.

Org Lett. 2010 May 7;12(9):2084-7. doi: 10.1021/ol100574y.

PMID:
20356070
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Privileged scaffolds for library design and drug discovery.

Welsch ME, Snyder SA, Stockwell BR.

Curr Opin Chem Biol. 2010 Jun;14(3):347-61. doi: 10.1016/j.cbpa.2010.02.018. Epub 2010 Mar 18. Review.

PMID:
20303320
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective.

Bauer RA, Wurst JM, Tan DS.

Curr Opin Chem Biol. 2010 Jun;14(3):308-14. doi: 10.1016/j.cbpa.2010.02.001. Epub 2010 Mar 2. Review.

PMID:
20202892
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids.

Díaz-Gavilán M, Galloway WR, O'Connell KM, Hodkingson JT, Spring DR.

Chem Commun (Camb). 2010 Feb 7;46(5):776-8. doi: 10.1039/b917965h. Epub 2009 Dec 14.

PMID:
20087517
[PubMed - indexed for MEDLINE]
10.

Highly diastereoselective addition of alkynylmagnesium chlorides to N-tert-butanesulfinyl aldimines: a practical and general access to chiral alpha-branched amines.

Chen BL, Wang B, Lin GQ.

J Org Chem. 2010 Feb 5;75(3):941-4. doi: 10.1021/jo902424m.

PMID:
20041724
[PubMed - indexed for MEDLINE]
11.

Quantifying biogenic bias in screening libraries.

Hert J, Irwin JJ, Laggner C, Keiser MJ, Shoichet BK.

Nat Chem Biol. 2009 Jul;5(7):479-83. doi: 10.1038/nchembio.180. Epub 2009 May 31.

PMID:
19483698
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

tert-Butanesulfinimines: structure, synthesis and synthetic applications.

Ferreira F, Botuha C, Chemla F, Pérez-Luna A.

Chem Soc Rev. 2009 Apr;38(4):1162-86. doi: 10.1039/b809772k. Epub 2009 Jan 26.

PMID:
19421587
[PubMed]
13.

Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries.

Nandy JP, Prakesch M, Khadem S, Reddy PT, Sharma U, Arya P.

Chem Rev. 2009 May;109(5):1999-2060. doi: 10.1021/cr800188v. Review. No abstract available.

PMID:
19249849
[PubMed - indexed for MEDLINE]
14.

The impact of natural products upon modern drug discovery.

Ganesan A.

Curr Opin Chem Biol. 2008 Jun;12(3):306-17. doi: 10.1016/j.cbpa.2008.03.016. Review.

PMID:
18423384
[PubMed - indexed for MEDLINE]
15.

Synthesis of indanones via solid-supported [2+2+2] cyclotrimerization.

Senaiar RS, Teske JA, Young DD, Deiters A.

J Org Chem. 2007 Sep 28;72(20):7801-4. Epub 2007 Sep 7.

PMID:
17824655
[PubMed]
16.

A general approach to chemo- and regioselective cyclotrimerization reactions.

Young DD, Deiters A.

Angew Chem Int Ed Engl. 2007;46(27):5187-90. No abstract available.

PMID:
17526034
[PubMed]
17.

Solid-supported [2+2+2] cyclotrimerizations.

Young DD, Senaiar RS, Deiters A.

Chemistry. 2006 Jul 17;12(21):5563-8.

PMID:
16755631
[PubMed]
18.

Pyridines via solid-supported [2 + 2 + 2] cyclotrimerization.

Senaiar RS, Young DD, Deiters A.

Chem Commun (Camb). 2006 Mar 28;(12):1313-5. Epub 2006 Feb 13.

PMID:
16538258
[PubMed]
19.

Diversity-oriented synthesis: exploring the intersections between chemistry and biology.

Tan DS.

Nat Chem Biol. 2005 Jul;1(2):74-84. Review.

PMID:
16408003
[PubMed - indexed for MEDLINE]
20.

Enantioselective reductive cyclization of 1,6-enynes via rhodium-catalyzed asymmetric hydrogenation: C-C bond formation precedes hydrogen activation.

Jang HY, Hughes FW, Gong H, Zhang J, Brodbelt JS, Krische MJ.

J Am Chem Soc. 2005 May 4;127(17):6174-5.

PMID:
15853314
[PubMed]

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