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Items: 1 to 20 of 46

1.

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism.

ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM.

Structure. 2010 Sep 8;18(9):1083-93. doi: 10.1016/j.str.2010.05.014.

2.

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2010 Mar 26;285(13):9919-31. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25.

3.

Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.

Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S.

J Biol Chem. 2010 Jan 1;285(1):723-30. doi: 10.1074/jbc.M109.033829. Epub 2009 Oct 27.

4.

Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

Parthier C, Reedtz-Runge S, Rudolph R, Stubbs MT.

Trends Biochem Sci. 2009 Jun;34(6):303-10. doi: 10.1016/j.tibs.2009.02.004. Epub 2009 May 14. Review.

PMID:
19446460
5.

Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor.

Bourgault S, Vaudry D, Ségalas-Milazzo I, Guilhaudis L, Couvineau A, Laburthe M, Vaudry H, Fournier A.

J Med Chem. 2009 May 28;52(10):3308-16. doi: 10.1021/jm900291j.

PMID:
19413310
6.

Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.

Pioszak AA, Parker NR, Suino-Powell K, Xu HE.

J Biol Chem. 2008 Nov 21;283(47):32900-12. doi: 10.1074/jbc.M805749200. Epub 2008 Sep 17.

7.

Class-B GPCR activation: is ligand helix-capping the key?

Neumann JM, Couvineau A, Murail S, Lacapère JJ, Jamin N, Laburthe M.

Trends Biochem Sci. 2008 Jul;33(7):314-9. doi: 10.1016/j.tibs.2008.05.001. Epub 2008 Jun 12.

PMID:
18555686
8.

Molecular recognition of parathyroid hormone by its G protein-coupled receptor.

Pioszak AA, Xu HE.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5034-9. doi: 10.1073/pnas.0801027105. Epub 2008 Mar 28.

9.

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R.

J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20.

10.

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghänel J, Rahfeld JU, Demuth HU, Stubbs MT.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. Epub 2007 Aug 21.

11.

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ.

Mol Pharmacol. 2007 Aug;72(2):280-90. Epub 2007 May 2.

12.

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

Sun C, Song D, Davis-Taber RA, Barrett LW, Scott VE, Richardson PL, Pereda-Lopez A, Uchic ME, Solomon LR, Lake MR, Walter KA, Hajduk PJ, Olejniczak ET.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7875-80. Epub 2007 Apr 30.

13.

Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand.

Grace CR, Perrin MH, Gulyas J, Digruccio MR, Cantle JP, Rivier JE, Vale WW, Riek R.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4858-63. Epub 2007 Mar 12.

14.

NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water.

Alaña I, Parker JC, Gault VA, Flatt PR, O'Harte FP, Malthouse JP, Hewage CM.

J Biol Chem. 2006 Jun 16;281(24):16370-6. Epub 2006 Apr 18.

15.

Ab initio prediction of peptide-MHC binding geometry for diverse class I MHC allotypes.

Bordner AJ, Abagyan R.

Proteins. 2006 May 15;63(3):512-26.

PMID:
16470819
16.

GROMACS: fast, flexible, and free.

Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJ.

J Comput Chem. 2005 Dec;26(16):1701-18.

PMID:
16211538
17.

NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor.

Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, Riek R.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12836-41. Epub 2004 Aug 23.

18.
19.

Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.

Dong M, Li Z, Pinon DI, Lybrand TP, Miller LJ.

J Biol Chem. 2004 Jan 23;279(4):2894-903. Epub 2003 Oct 30.

20.

International Union of Pharmacology. XXXV. The glucagon receptor family.

Mayo KE, Miller LJ, Bataille D, Dalle S, Göke B, Thorens B, Drucker DJ.

Pharmacol Rev. 2003 Mar;55(1):167-94. Review.

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