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References for PMC Articles for PubMed (Select 21325649)


Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.

You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C, Liu Y.

Mol Cell Biol. 2010 Apr;30(7):1650-9. doi: 10.1128/MCB.01307-09. Epub 2010 Jan 19.


Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ.

Cell Metab. 2009 Nov;10(5):343-54. doi: 10.1016/j.cmet.2009.09.008.


The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.

Cota D, Matter EK, Woods SC, Seeley RJ.

J Neurosci. 2008 Jul 9;28(28):7202-8. doi: 10.1523/JNEUROSCI.1389-08.2008.


Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.


LRb signals act within a distributed network of leptin-responsive neurones to mediate leptin action.

Leinninger GM, Myers MG Jr.

Acta Physiol (Oxf). 2008 Jan;192(1):49-59. doi: 10.1111/j.1748-1716.2007.01784.x. Review.


Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation.

Plum L, Rother E, Münzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Könner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Brüning JC.

Cell Metab. 2007 Dec;6(6):431-45.


Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.

Björnholm M, Münzberg H, Leshan RL, Villanueva EC, Bates SH, Louis GW, Jones JC, Ishida-Takahashi R, Bjørbaek C, Myers MG Jr.

J Clin Invest. 2007 May;117(5):1354-60. Epub 2007 Apr 5.


Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS.

Cell Metab. 2006 Aug;4(2):123-32.


Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.


Hypothalamic mTOR signaling regulates food intake.

Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ.

Science. 2006 May 12;312(5775):927-30.


Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB.

J Biol Chem. 2006 Jul 14;281(28):18933-41. Epub 2006 May 10.


Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7. Epub 2005 Jul 26.


PI3K integrates the action of insulin and leptin on hypothalamic neurons.

Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS.

J Clin Invest. 2005 Apr;115(4):951-8. Epub 2005 Mar 10.


Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

Dunn SL, Björnholm M, Bates SH, Chen Z, Seifert M, Myers MG Jr.

Mol Endocrinol. 2005 Apr;19(4):925-38. Epub 2004 Dec 16.


Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.

Mirshamsi S, Laidlaw HA, Ning K, Anderson E, Burgess LA, Gray A, Sutherland C, Ashford ML.

BMC Neurosci. 2004 Dec 6;5:54.

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