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Results: 1 to 20 of 34

1.

Asymmetric activation of the hsp90 dimer by its cochaperone aha1.

Retzlaff M, Hagn F, Mitschke L, Hessling M, Gugel F, Kessler H, Richter K, Buchner J.

Mol Cell. 2010 Feb 12;37(3):344-54. doi: 10.1016/j.molcel.2010.01.006.

PMID:
20159554
[PubMed - indexed for MEDLINE]
Free Article
2.

Modular control of cross-oligomerization: analysis of superstabilized Hsp90 homodimers in vivo.

Wayne N, Lai Y, Pullen L, Bolon DN.

J Biol Chem. 2010 Jan 1;285(1):234-41. doi: 10.1074/jbc.M109.060129. Epub 2009 Nov 11.

PMID:
19906642
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis.

Mickler M, Hessling M, Ratzke C, Buchner J, Hugel T.

Nat Struct Mol Biol. 2009 Mar;16(3):281-6. doi: 10.1038/nsmb.1557. Epub 2009 Feb 22.

PMID:
19234469
[PubMed - indexed for MEDLINE]
4.

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

Hessling M, Richter K, Buchner J.

Nat Struct Mol Biol. 2009 Mar;16(3):287-93. doi: 10.1038/nsmb.1565. Epub 2009 Feb 22.

PMID:
19234467
[PubMed - indexed for MEDLINE]
5.

Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle.

Southworth DR, Agard DA.

Mol Cell. 2008 Dec 5;32(5):631-40. doi: 10.1016/j.molcel.2008.10.024.

PMID:
19061638
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Discovery and development of heat shock protein 90 inhibitors.

Taldone T, Sun W, Chiosis G.

Bioorg Med Chem. 2009 Mar 15;17(6):2225-35. doi: 10.1016/j.bmc.2008.10.087. Epub 2008 Nov 6. Review.

PMID:
19017562
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.

Cunningham CN, Krukenberg KA, Agard DA.

J Biol Chem. 2008 Jul 25;283(30):21170-8. doi: 10.1074/jbc.M800046200. Epub 2008 May 20.

PMID:
18492664
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90.

Krukenberg KA, Förster F, Rice LM, Sali A, Agard DA.

Structure. 2008 May;16(5):755-65. doi: 10.1016/j.str.2008.01.021.

PMID:
18462680
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers.

Wayne N, Bolon DN.

J Biol Chem. 2007 Nov 30;282(48):35386-95. Epub 2007 Oct 1.

PMID:
17908693
[PubMed - indexed for MEDLINE]
Free Article
10.

Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.

Shiau AK, Harris SF, Southworth DR, Agard DA.

Cell. 2006 Oct 20;127(2):329-40.

PMID:
17055434
[PubMed - indexed for MEDLINE]
Free Article
11.

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.

Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH.

Nature. 2006 Apr 20;440(7087):1013-7.

PMID:
16625188
[PubMed - indexed for MEDLINE]
12.

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins.

McLaughlin SH, Sobott F, Yao ZP, Zhang W, Nielsen PR, Grossmann JG, Laue ED, Robinson CV, Jackson SE.

J Mol Biol. 2006 Feb 24;356(3):746-58. Epub 2005 Dec 15.

PMID:
16403413
[PubMed - indexed for MEDLINE]
13.

HSP90 and the chaperoning of cancer.

Whitesell L, Lindquist SL.

Nat Rev Cancer. 2005 Oct;5(10):761-72. Review.

PMID:
16175177
[PubMed - indexed for MEDLINE]
14.

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform.

McLaughlin SH, Ventouras LA, Lobbezoo B, Jackson SE.

J Mol Biol. 2004 Nov 26;344(3):813-26.

PMID:
15533447
[PubMed - indexed for MEDLINE]
15.

The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle.

Richter K, Walter S, Buchner J.

J Mol Biol. 2004 Oct 1;342(5):1403-13.

PMID:
15364569
[PubMed - indexed for MEDLINE]
16.

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

Meyer P, Prodromou C, Liao C, Hu B, Mark Roe S, Vaughan CK, Vlasic I, Panaretou B, Piper PW, Pearl LH.

EMBO J. 2004 Feb 11;23(3):511-9. Epub 2004 Jan 22. Erratum in: EMBO J. 2004 Mar 24;23(6):1402. Corrected and republished in: EMBO J. 2004 Mar 24;23(6):1402-10.

PMID:
14739935
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C.

Mol Cell. 2002 Dec;10(6):1307-18.

PMID:
12504007
[PubMed - indexed for MEDLINE]
Free Article
18.

Automated design of specificity in molecular recognition.

Havranek JJ, Harbury PB.

Nat Struct Biol. 2003 Jan;10(1):45-52.

PMID:
12459719
[PubMed - indexed for MEDLINE]
19.

N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle.

Richter K, Reinstein J, Buchner J.

J Biol Chem. 2002 Nov 22;277(47):44905-10. Epub 2002 Sep 13.

PMID:
12235160
[PubMed - indexed for MEDLINE]
Free Article
20.

Structure, function, and mechanism of the Hsp90 molecular chaperone.

Pearl LH, Prodromou C.

Adv Protein Chem. 2001;59:157-86. Review. No abstract available.

PMID:
11868271
[PubMed - indexed for MEDLINE]

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