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Results: 1 to 20 of 29

1.

Inhibition of mutated, activated BRAF in metastatic melanoma.

Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB.

N Engl J Med. 2010 Aug 26;363(9):809-19. doi: 10.1056/NEJMoa1002011.

PMID:
20818844
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

BRAF as therapeutic target in melanoma.

Wellbrock C, Hurlstone A.

Biochem Pharmacol. 2010 Sep 1;80(5):561-7. doi: 10.1016/j.bcp.2010.03.019. Epub 2010 Mar 27. Review.

PMID:
20350535
[PubMed - indexed for MEDLINE]
3.

Darwin and evolutionary tales in leukemia. The Ham-Wasserman Lecture.

Greaves M.

Hematology Am Soc Hematol Educ Program. 2009:3-12. doi: 10.1182/asheducation-2009.1.3.

PMID:
20008176
[PubMed - indexed for MEDLINE]
Free Article
4.

Polyclonality of BRAF mutations in acquired melanocytic nevi.

Lin J, Takata M, Murata H, Goto Y, Kido K, Ferrone S, Saida T.

J Natl Cancer Inst. 2009 Oct 21;101(20):1423-7. doi: 10.1093/jnci/djp309. Epub 2009 Sep 14.

PMID:
19752400
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Oncogenic Braf induces melanocyte senescence and melanoma in mice.

Dhomen N, Reis-Filho JS, da Rocha Dias S, Hayward R, Savage K, Delmas V, Larue L, Pritchard C, Marais R.

Cancer Cell. 2009 Apr 7;15(4):294-303. doi: 10.1016/j.ccr.2009.02.022.

PMID:
19345328
[PubMed - indexed for MEDLINE]
Free Article
6.

Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma.

Greene VR, Johnson MM, Grimm EA, Ellerhorst JA.

J Invest Dermatol. 2009 Jun;129(6):1483-8. doi: 10.1038/jid.2008.374.

PMID:
19037234
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells.

Sala E, Mologni L, Truffa S, Gaetano C, Bollag GE, Gambacorti-Passerini C.

Mol Cancer Res. 2008 May;6(5):751-9. doi: 10.1158/1541-7786.MCR-07-2001. Epub 2008 May 5.

PMID:
18458053
[PubMed - indexed for MEDLINE]
Free Article
8.

Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.

Houben R, Vetter-Kauczok CS, Ortmann S, Rapp UR, Broecker EB, Becker JC.

J Invest Dermatol. 2008 Aug;128(8):2003-12. doi: 10.1038/jid.2008.30. Epub 2008 Mar 6.

PMID:
18323787
[PubMed - indexed for MEDLINE]
Free Article
9.

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim SH, Schlessinger J, Zhang KY, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6. doi: 10.1073/pnas.0711741105. Epub 2008 Feb 19.

PMID:
18287029
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR.

Cell. 2008 Feb 8;132(3):363-74. doi: 10.1016/j.cell.2007.12.032.

PMID:
18267069
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Melanoma biology and new targeted therapy.

Gray-Schopfer V, Wellbrock C, Marais R.

Nature. 2007 Feb 22;445(7130):851-7. Review.

PMID:
17314971
[PubMed - indexed for MEDLINE]
12.

Functional characterization of the T1799-1801del and A1799-1816ins BRAF mutations in papillary thyroid cancer.

Hou P, Liu D, Xing M.

Cell Cycle. 2007 Feb 1;6(3):377-9. Epub 2007 Feb 5. No abstract available.

PMID:
17297294
[PubMed - indexed for MEDLINE]
Free Article
13.

Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants.

Hocker T, Tsao H.

Hum Mutat. 2007 Jun;28(6):578-88. Review.

PMID:
17295241
[PubMed - indexed for MEDLINE]
14.

Somatic activation of KIT in distinct subtypes of melanoma.

Curtin JA, Busam K, Pinkel D, Bastian BC.

J Clin Oncol. 2006 Sep 10;24(26):4340-6. Epub 2006 Aug 14.

PMID:
16908931
[PubMed - indexed for MEDLINE]
Free Article
15.

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

Gray-Schopfer VC, Cheong SC, Chong H, Chow J, Moss T, Abdel-Malek ZA, Marais R, Wynford-Thomas D, Bennett DC.

Br J Cancer. 2006 Aug 21;95(4):496-505. Epub 2006 Aug 1.

PMID:
16880792
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi.

Ichii-Nakato N, Takata M, Takayanagi S, Takashima S, Lin J, Murata H, Fujimoto A, Hatta N, Saida T.

J Invest Dermatol. 2006 Sep;126(9):2111-8. Epub 2006 May 11.

PMID:
16691193
[PubMed - indexed for MEDLINE]
Free Article
17.

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models.

Hoeflich KP, Gray DC, Eby MT, Tien JY, Wong L, Bower J, Gogineni A, Zha J, Cole MJ, Stern HM, Murray LJ, Davis DP, Seshagiri S.

Cancer Res. 2006 Jan 15;66(2):999-1006.

PMID:
16424035
[PubMed - indexed for MEDLINE]
Free Article
18.

Distinct sets of genetic alterations in melanoma.

Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian BC.

N Engl J Med. 2005 Nov 17;353(20):2135-47.

PMID:
16291983
[PubMed - indexed for MEDLINE]
Free Article
19.

Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases.

Kirschner M, Helmke B, Starz H, Benner A, Thome M, Deichmann M.

Melanoma Res. 2005 Oct;15(5):427-34.

PMID:
16179870
[PubMed - indexed for MEDLINE]
20.

BRAFE600-associated senescence-like cell cycle arrest of human naevi.

Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS.

Nature. 2005 Aug 4;436(7051):720-4.

PMID:
16079850
[PubMed - indexed for MEDLINE]
Free Article

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