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Results: 1 to 20 of 47

1.

Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1alpha.

Lucas EK, Markwardt SJ, Gupta S, Meador-Woodruff JH, Lin JD, Overstreet-Wadiche L, Cowell RM.

J Neurosci. 2010 May 26;30(21):7227-35. doi: 10.1523/JNEUROSCI.0698-10.2010.

PMID:
20505089
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease.

Buckley NJ, Johnson R, Zuccato C, Bithell A, Cattaneo E.

Neurobiol Dis. 2010 Jul;39(1):28-39. doi: 10.1016/j.nbd.2010.02.003. Epub 2010 Feb 17. Review.

PMID:
20170730
[PubMed - indexed for MEDLINE]
3.

Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease.

Levine MS, Cepeda C, André VM.

Neuron. 2010 Jan 28;65(2):145-7. doi: 10.1016/j.neuron.2010.01.010. Review.

PMID:
20152121
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.

Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ.

J Biol Chem. 2010 Apr 2;285(14):10653-61. doi: 10.1074/jbc.M109.083287. Epub 2010 Feb 9.

PMID:
20145253
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.

Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22480-5. doi: 10.1073/pnas.0911503106. Epub 2009 Dec 11.

PMID:
20018729
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond.

Ilieva H, Polymenidou M, Cleveland DW.

J Cell Biol. 2009 Dec 14;187(6):761-72. doi: 10.1083/jcb.200908164. Epub . Review.

PMID:
19951898
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Expression analysis of novel striatal-enriched genes in Huntington disease.

Mazarei G, Neal SJ, Becanovic K, Luthi-Carter R, Simpson EM, Leavitt BR.

Hum Mol Genet. 2010 Feb 15;19(4):609-22. doi: 10.1093/hmg/ddp527. Epub 2009 Nov 23.

PMID:
19934114
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.

Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA.

Nat Med. 2009 Dec;15(12):1407-13. doi: 10.1038/nm.2056. Epub 2009 Nov 15.

PMID:
19915593
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

Gibson GE, Starkov A, Blass JP, Ratan RR, Beal MF.

Biochim Biophys Acta. 2010 Jan;1802(1):122-34. doi: 10.1016/j.bbadis.2009.08.010. Epub 2009 Aug 26. Review.

PMID:
19715758
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Brain-derived neurotrophic factor in neurodegenerative diseases.

Zuccato C, Cattaneo E.

Nat Rev Neurol. 2009 Jun;5(6):311-22. doi: 10.1038/nrneurol.2009.54. Review.

PMID:
19498435
[PubMed - indexed for MEDLINE]
11.

The Nrf2-ARE cytoprotective pathway in astrocytes.

Vargas MR, Johnson JA.

Expert Rev Mol Med. 2009 Jun 3;11:e17. doi: 10.1017/S1462399409001094. Review.

PMID:
19490732
[PubMed - indexed for MEDLINE]
12.

M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras.

Keduka E, Kaiho A, Hamada M, Watanabe-Takano H, Takano K, Ogasawara M, Satou Y, Satoh N, Endo T.

Gene. 2009 Jan 15;429(1-2):49-58. doi: 10.1016/j.gene.2008.10.001. Epub 2008 Oct 11.

PMID:
18977283
[PubMed - indexed for MEDLINE]
13.

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.

Benn CL, Sun T, Sadri-Vakili G, McFarland KN, DiRocco DP, Yohrling GJ, Clark TW, Bouzou B, Cha JH.

J Neurosci. 2008 Oct 15;28(42):10720-33. doi: 10.1523/JNEUROSCI.2126-08.2008.

PMID:
18923047
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9. doi: 10.1073/pnas.0804249105. Epub 2008 Sep 30.

PMID:
18829438
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

Runne H, Régulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Déglon N, Luthi-Carter R.

J Neurosci. 2008 Sep 24;28(39):9723-31. doi: 10.1523/JNEUROSCI.3044-08.2008.

PMID:
18815258
[PubMed - indexed for MEDLINE]
Free Article
16.

Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse.

Brown TB, Bogush AI, Ehrlich ME.

Hum Mol Genet. 2008 Oct 15;17(20):3095-104. doi: 10.1093/hmg/ddn206. Epub 2008 Jul 16.

PMID:
18632688
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease.

Desplats PA, Lambert JR, Thomas EA.

Neurobiol Dis. 2008 Sep;31(3):298-308. doi: 10.1016/j.nbd.2008.05.005. Epub 2008 May 22.

PMID:
18595722
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'.

Kuhn A, Luthi-Carter R, Delorenzi M.

BMC Bioinformatics. 2008 Jan 17;9:26. doi: 10.1186/1471-2105-9-26.

PMID:
18201381
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.

Strand AD, Baquet ZC, Aragaki AK, Holmans P, Yang L, Cleren C, Beal MF, Jones L, Kooperberg C, Olson JM, Jones KR.

J Neurosci. 2007 Oct 24;27(43):11758-68.

PMID:
17959817
[PubMed - indexed for MEDLINE]
Free Article
20.

Polyglutamine diseases: emerging concepts in pathogenesis and therapy.

Shao J, Diamond MI.

Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R115-23. Review.

PMID:
17911155
[PubMed - indexed for MEDLINE]
Free Article

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