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Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.

Bosanac I, Wertz IE, Pan B, Yu C, Kusam S, Lam C, Phu L, Phung Q, Maurer B, Arnott D, Kirkpatrick DS, Dixit VM, Hymowitz SG.

Mol Cell. 2010 Nov 24;40(4):548-57. doi: 10.1016/j.molcel.2010.10.009.


B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice.

Chu Y, Vahl JC, Kumar D, Heger K, Bertossi A, Wójtowicz E, Soberon V, Schenten D, Mack B, Reutelshöfer M, Beyaert R, Amann K, van Loo G, Schmidt-Supprian M.

Blood. 2011 Feb 17;117(7):2227-36. doi: 10.1182/blood-2010-09-306019. Epub 2010 Nov 18.


Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.

Conze DB, Zhao Y, Ashwell JD.

PLoS Biol. 2010 Oct 26;8(10):e1000518. doi: 10.1371/journal.pbio.1000518. Erratum in: PLoS Biol. 2016 Jun;14(6):e1002502.


Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

Rodrigo-Brenni MC, Foster SA, Morgan DO.

Mol Cell. 2010 Aug 27;39(4):548-59. doi: 10.1016/j.molcel.2010.07.027.


Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.

Arimoto K, Funami K, Saeki Y, Tanaka K, Okawa K, Takeuchi O, Akira S, Murakami Y, Shimotohno K.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15856-61. doi: 10.1073/pnas.1004621107. Epub 2010 Aug 19.


The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A.

Immunity. 2010 Aug 27;33(2):181-91. doi: 10.1016/j.immuni.2010.07.017. Epub 2010 Aug 12.


K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.

Matsumoto ML, Wickliffe KE, Dong KC, Yu C, Bosanac I, Bustos D, Phu L, Kirkpatrick DS, Hymowitz SG, Rape M, Kelley RF, Dixit VM.

Mol Cell. 2010 Aug 13;39(3):477-84. doi: 10.1016/j.molcel.2010.07.001. Epub 2010 Jul 22.


K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling.

Huang H, Jeon MS, Liao L, Yang C, Elly C, Yates JR 3rd, Liu YC.

Immunity. 2010 Jul 23;33(1):60-70. doi: 10.1016/j.immuni.2010.07.002. Erratum in: Immunity. 2010 Nov 24;33(5):830.


TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.

Zucchelli S, Codrich M, Marcuzzi F, Pinto M, Vilotti S, Biagioli M, Ferrer I, Gustincich S.

Hum Mol Genet. 2010 Oct 1;19(19):3759-70. doi: 10.1093/hmg/ddq290. Epub 2010 Jul 14.


Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

Bremm A, Freund SM, Komander D.

Nat Struct Mol Biol. 2010 Aug;17(8):939-47. doi: 10.1038/nsmb.1873. Epub 2010 Jul 11.


Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation.

Scheper J, Guerra-Rebollo M, Sanclimens G, Moure A, Masip I, González-Ruiz D, Rubio N, Crosas B, Meca-Cortés O, Loukili N, Plans V, Morreale A, Blanco J, Ortiz AR, Messeguer A, Thomson TM.

PLoS One. 2010 Jun 30;5(6):e11403. doi: 10.1371/journal.pone.0011403.


The diversity of ubiquitin recognition: hot spots and varied specificity.

Winget JM, Mayor T.

Mol Cell. 2010 Jun 11;38(5):627-35. doi: 10.1016/j.molcel.2010.05.003. Review.


Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.

Vereecke L, Sze M, Mc Guire C, Rogiers B, Chu Y, Schmidt-Supprian M, Pasparakis M, Beyaert R, van Loo G.

J Exp Med. 2010 Jul 5;207(7):1513-23. doi: 10.1084/jem.20092474. Epub 2010 Jun 7.


The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.

Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C.

Immunity. 2010 May 28;32(5):670-80. doi: 10.1016/j.immuni.2010.05.002. Epub 2010 May 20.


Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

Zeng W, Sun L, Jiang X, Chen X, Hou F, Adhikari A, Xu M, Chen ZJ.

Cell. 2010 Apr 16;141(2):315-30. doi: 10.1016/j.cell.2010.03.029.


Cbl-b and itch: key regulators of peripheral T-cell tolerance.

Venuprasad K.

Cancer Res. 2010 Apr 15;70(8):3009-12. doi: 10.1158/0008-5472.CAN-09-4076. Review.


Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.

Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.

J Exp Med. 2010 May 10;207(5):983-97. doi: 10.1084/jem.20092437. Epub 2010 Apr 12.


Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.

Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.

J Exp Med. 2010 May 10;207(5):973-81. doi: 10.1084/jem.20092308. Epub 2010 Apr 12.


TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.

Cejas PJ, Walsh MC, Pearce EL, Han D, Harms GM, Artis D, Turka LA, Choi Y.

Blood. 2010 Jun 10;115(23):4750-7. doi: 10.1182/blood-2009-09-242768. Epub 2010 Mar 29.


Signaling to NF-kappaB: regulation by ubiquitination.

Wertz IE, Dixit VM.

Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a003350. doi: 10.1101/cshperspect.a003350. Review.

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