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Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks.

Gleichmann M, Zhang Y, Wood WH 3rd, Becker KG, Mughal MR, Pazin MJ, van Praag H, Kobilo T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP.

Neurobiol Aging. 2012 Jan;33(1):205.e1-18. doi: 10.1016/j.neurobiolaging.2010.08.012. Epub 2010 Oct 13.


The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

Liu D, Pitta M, Lee JH, Ray B, Lahiri DK, Furukawa K, Mughal M, Jiang H, Villarreal J, Cutler RG, Greig NH, Mattson MP.

J Alzheimers Dis. 2010;22(2):443-57. doi: 10.3233/JAD-2010-101017.


Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA.

J Biol Chem. 2010 Sep 3;285(36):28191-9. doi: 10.1074/jbc.M109.082883. Epub 2010 Jun 23.


Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys.

Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW.

J Neurosci. 2010 Apr 28;30(17):6058-71. doi: 10.1523/JNEUROSCI.3956-09.2010.


Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice.

Gengler S, McClean PL, McCurtin R, Gault VA, Hölscher C.

Neurobiol Aging. 2012 Feb;33(2):265-76. doi: 10.1016/j.neurobiolaging.2010.02.014. Epub 2010 Mar 31.


Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels.

Bolós M, Fernandez S, Torres-Aleman I.

J Biol Chem. 2010 Jun 4;285(23):17693-700. doi: 10.1074/jbc.M109.096594. Epub 2010 Mar 29.


NOX activity in brain aging: exacerbation by high fat diet.

Bruce-Keller AJ, White CL, Gupta S, Knight AG, Pistell PJ, Ingram DK, Morrison CD, Keller JN.

Free Radic Biol Med. 2010 Jul 1;49(1):22-30. doi: 10.1016/j.freeradbiomed.2010.03.006. Epub 2010 Mar 25.


Neural mechanisms of ageing and cognitive decline.

Bishop NA, Lu T, Yankner BA.

Nature. 2010 Mar 25;464(7288):529-35. doi: 10.1038/nature08983. Review.


ER calcium and Alzheimer's disease: in a state of flux.

Mattson MP.

Sci Signal. 2010 Mar 23;3(114):pe10. doi: 10.1126/scisignal.3114pe10. Review.


GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, Tweedie D, Perry T, Mattson MP, Kapogiannis D, Sambamurti K, Lahiri DK, Greig NH.

J Alzheimers Dis. 2010;19(4):1205-19. doi: 10.3233/JAD-2010-1314.


Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging.

Gunstad J, Lhotsky A, Wendell CR, Ferrucci L, Zonderman AB.

Neuroepidemiology. 2010;34(4):222-9. doi: 10.1159/000297742. Epub 2010 Mar 18.


Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes.

Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7036-41. doi: 10.1073/pnas.1000645107. Epub 2010 Mar 15.


Exercise and time-dependent benefits to learning and memory.

Berchtold NC, Castello N, Cotman CW.

Neuroscience. 2010 May 19;167(3):588-97. doi: 10.1016/j.neuroscience.2010.02.050. Epub 2010 Feb 26.


Age and energy intake interact to modify cell stress pathways and stroke outcome.

Arumugam TV, Phillips TM, Cheng A, Morrell CH, Mattson MP, Wan R.

Ann Neurol. 2010 Jan;67(1):41-52. doi: 10.1002/ana.21798.


Running reduces stress and enhances cell genesis in aged mice.

Kannangara TS, Lucero MJ, Gil-Mohapel J, Drapala RJ, Simpson JM, Christie BR, van Praag H.

Neurobiol Aging. 2011 Dec;32(12):2279-86. doi: 10.1016/j.neurobiolaging.2009.12.025. Epub 2010 Jan 27.


Physical activity and incident cognitive impairment in elderly persons: the INVADE study.

Etgen T, Sander D, Huntgeburth U, Poppert H, Förstl H, Bickel H.

Arch Intern Med. 2010 Jan 25;170(2):186-93. doi: 10.1001/archinternmed.2009.498.


Functional alterations in memory networks in early Alzheimer's disease.

Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA.

Neuromolecular Med. 2010 Mar;12(1):27-43. doi: 10.1007/s12017-009-8109-7. Review.


Physical exercise, aging, and mild cognitive impairment: a population-based study.

Geda YE, Roberts RO, Knopman DS, Christianson TJ, Pankratz VS, Ivnik RJ, Boeve BF, Tangalos EG, Petersen RC, Rocca WA.

Arch Neurol. 2010 Jan;67(1):80-6. doi: 10.1001/archneurol.2009.297.


Effects of aerobic exercise on mild cognitive impairment: a controlled trial.

Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, Plymate SR, Fishel MA, Watson GS, Cholerton BA, Duncan GE, Mehta PD, Craft S.

Arch Neurol. 2010 Jan;67(1):71-9. doi: 10.1001/archneurol.2009.307.


Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.

D'Amico M, Di Filippo C, Marfella R, Abbatecola AM, Ferraraccio F, Rossi F, Paolisso G.

Exp Gerontol. 2010 Mar;45(3):202-7. doi: 10.1016/j.exger.2009.12.004. Epub 2009 Dec 11. Erratum in: Exp Gerontol. 2013 Sep;48(9):1002.

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