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Items: 1 to 20 of 65


The human Mediator complex: a versatile, genome-wide regulator of transcription.

Taatjes DJ.

Trends Biochem Sci. 2010 Jun;35(6):315-22. doi: 10.1016/j.tibs.2010.02.004. Epub 2010 Mar 17. Review.


MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.

Grøntved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S.

Mol Cell Biol. 2010 May;30(9):2155-69. doi: 10.1128/MCB.01238-09. Epub 2010 Mar 1.


Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes.

Rana R, Chen Y, Ferguson SS, Kissling GE, Surapureddi S, Goldstein JA.

Drug Metab Dispos. 2010 Apr;38(4):591-9. doi: 10.1124/dmd.109.030387. Epub 2010 Jan 19.


The transcriptional regulation of the human CYP2C genes.

Chen Y, Goldstein JA.

Curr Drug Metab. 2009 Jul;10(6):567-78. Epub 2009 Jul 15. Review.


Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha.

Inoue K, Negishi M.

FEBS Lett. 2009 Jun 18;583(12):2126-30. doi: 10.1016/j.febslet.2009.05.031. Epub 2009 May 23.


Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM.

PLoS One. 2009;4(5):e5609. doi: 10.1371/journal.pone.0005609. Epub 2009 May 19.


Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.

Surapureddi S, Rana R, Reddy JK, Goldstein JA.

Mol Pharmacol. 2008 Sep;74(3):913-23. doi: 10.1124/mol.108.048983. Epub 2008 Jun 13.


Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription.

Gonzalez FJ.

Drug Metab Pharmacokinet. 2008;23(1):2-7. Review.


Proteomic analysis of microvesicles derived from human colorectal cancer cells.

Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS.

J Proteome Res. 2007 Dec;6(12):4646-55. Epub 2007 Oct 24.


Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA.

Kamiyama Y, Matsubara T, Yoshinari K, Nagata K, Kamimura H, Yamazoe Y.

Drug Metab Pharmacokinet. 2007 Aug;22(4):287-98.


MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.

Lee HK, Park UH, Kim EJ, Um SJ.

EMBO J. 2007 Aug 8;26(15):3545-57. Epub 2007 Jul 19.


Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance.

Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy JK, Evans RM, Rosenfeld MG, Hunter T.

Cell Metab. 2006 Feb;3(2):111-22.


Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression.

Inoue Y, Peters LL, Yim SH, Inoue J, Gonzalez FJ.

J Mol Med (Berl). 2006 Apr;84(4):334-44. Epub 2005 Dec 31.


Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease.

Sanyal AJ.

Nat Clin Pract Gastroenterol Hepatol. 2005 Jan;2(1):46-53. Review.


Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.

Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, Inoue J, Xiang CC, Brownstein MJ, Eggertsen G, Björkhem I, Gonzalez FJ.

J Lipid Res. 2006 Jan;47(1):215-27. Epub 2005 Nov 1.


Dynamic regulation of pol II transcription by the mammalian Mediator complex.

Malik S, Roeder RG.

Trends Biochem Sci. 2005 May;30(5):256-63. Review.


The metabolic syndrome.

Eckel RH, Grundy SM, Zimmet PZ.

Lancet. 2005 Apr 16-22;365(9468):1415-28. Review.


Transcriptional regulation of the human CYP2A6 gene.

Pitarque M, Rodríguez-Antona C, Oscarson M, Ingelman-Sundberg M.

J Pharmacol Exp Ther. 2005 May;313(2):814-22. Epub 2005 Jan 25.


Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver.

Kamiya A, Inoue Y, Kodama T, Gonzalez FJ.

FEBS Lett. 2004 Dec 3;578(1-2):63-8.

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