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Results: 1 to 20 of 46

1.

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.

Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, Lewis J, Petrucelli L.

J Neurosci. 2010 Aug 11;30(32):10851-9. doi: 10.1523/JNEUROSCI.1630-10.2010.

PMID:
20702714
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

Tsai KJ, Yang CH, Fang YH, Cho KH, Chien WL, Wang WT, Wu TW, Lin CP, Fu WM, Shen CK.

J Exp Med. 2010 Aug 2;207(8):1661-73. doi: 10.1084/jem.20092164. Epub 2010 Jul 26.

PMID:
20660618
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13318-23. doi: 10.1073/pnas.1008227107. Epub 2010 Jul 12.

PMID:
20624952
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Neurotoxic effects of TDP-43 overexpression in C. elegans.

Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD.

Hum Mol Genet. 2010 Aug 15;19(16):3206-18. doi: 10.1093/hmg/ddq230. Epub 2010 Jun 8.

PMID:
20530643
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.

Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD.

Acta Neuropathol. 2010 Apr;119(4):409-19. doi: 10.1007/s00401-010-0659-0. Epub 2010 Mar 3.

PMID:
20198480
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control.

Sun S, Zhang Z, Sinha R, Karni R, Krainer AR.

Nat Struct Mol Biol. 2010 Mar;17(3):306-12. doi: 10.1038/nsmb.1750. Epub 2010 Feb 7.

PMID:
20139984
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A Drosophila model for TDP-43 proteinopathy.

Li Y, Ray P, Rao EJ, Shi C, Guo W, Chen X, Woodruff EA 3rd, Fushimi K, Wu JY.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3169-74. doi: 10.1073/pnas.0913602107. Epub 2010 Jan 26.

PMID:
20133767
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.

Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, Smits V, Ceuterick-de Groote C, Van Broeckhoven C, Kumar-Singh S.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3858-63. doi: 10.1073/pnas.0912417107. Epub 2010 Feb 3.

PMID:
20133711
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

TDP-43 is a developmentally regulated protein essential for early embryonic development.

Sephton CF, Good SK, Atkin S, Dewey CM, Mayer P 3rd, Herz J, Yu G.

J Biol Chem. 2010 Feb 26;285(9):6826-34. doi: 10.1074/jbc.M109.061846. Epub 2009 Dec 29. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740.

PMID:
20040602
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Wu LS, Cheng WC, Hou SC, Yan YT, Jiang ST, Shen CK.

Genesis. 2010 Jan;48(1):56-62. doi: 10.1002/dvg.20584.

PMID:
20014337
[PubMed - indexed for MEDLINE]
11.

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.

Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18809-14. doi: 10.1073/pnas.0908767106. Epub 2009 Oct 15.

PMID:
19833869
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.

Pesiridis GS, Lee VM, Trojanowski JQ.

Hum Mol Genet. 2009 Oct 15;18(R2):R156-62. doi: 10.1093/hmg/ddp303. Review.

PMID:
19808791
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy.

Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ.

Acta Neuropathol. 2009 Nov;118(5):633-45. doi: 10.1007/s00401-009-0571-7. Epub 2009 Jul 18.

PMID:
19618195
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.

D'Ambrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala YM, Baralle FE.

Nucleic Acids Res. 2009 Jul;37(12):4116-26. doi: 10.1093/nar/gkp342. Epub 2009 May 8.

PMID:
19429692
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior.

Feiguin F, Godena VK, Romano G, D'Ambrogio A, Klima R, Baralle FE.

FEBS Lett. 2009 May 19;583(10):1586-92. doi: 10.1016/j.febslet.2009.04.019. Epub 2009 Apr 19.

PMID:
19379745
[PubMed - indexed for MEDLINE]
Free Article
16.

CLIP: construction of cDNA libraries for high-throughput sequencing from RNAs cross-linked to proteins in vivo.

Wang Z, Tollervey J, Briese M, Turner D, Ule J.

Methods. 2009 Jul;48(3):287-93. doi: 10.1016/j.ymeth.2009.02.021. Epub 2009 Mar 9.

PMID:
19272451
[PubMed - indexed for MEDLINE]
17.

Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells.

Matsuda D, Sato H, Maquat LE.

Methods Enzymol. 2008;449:177-201. doi: 10.1016/S0076-6879(08)02409-9.

PMID:
19215759
[PubMed - indexed for MEDLINE]
18.

Structural insights into TDP-43 in nucleic-acid binding and domain interactions.

Kuo PH, Doudeva LG, Wang YT, Shen CK, Yuan HS.

Nucleic Acids Res. 2009 Apr;37(6):1799-808. doi: 10.1093/nar/gkp013. Epub 2009 Jan 27.

PMID:
19174564
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

An integrated workflow for charting the human interaction proteome: insights into the PP2A system.

Glatter T, Wepf A, Aebersold R, Gstaiger M.

Mol Syst Biol. 2009;5:237. doi: 10.1038/msb.2008.75. Epub 2009 Jan 20.

PMID:
19156129
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.

Rossbach O, Hung LH, Schreiner S, Grishina I, Heiner M, Hui J, Bindereif A.

Mol Cell Biol. 2009 Mar;29(6):1442-51. doi: 10.1128/MCB.01689-08. Epub 2009 Jan 5.

PMID:
19124611
[PubMed - indexed for MEDLINE]
Free PMC Article

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