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Items: 1 to 20 of 45

1.

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.

Cao Y, Li H, Liu H, Zheng C, Ji H, Liu X.

Cell Res. 2010 Jan;20(1):99-108. doi: 10.1038/cr.2009.141. Epub 2009 Dec 22.

PMID:
20029389
2.

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.

Tamás P, Macintyre A, Finlay D, Clarke R, Feijoo-Carnero C, Ashworth A, Cantrell D.

Eur J Immunol. 2010 Jan;40(1):242-53. doi: 10.1002/eji.200939677.

3.

LKB1 regulates pancreatic beta cell size, polarity, and function.

Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ Jr, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y.

Cell Metab. 2009 Oct;10(4):296-308. doi: 10.1016/j.cmet.2009.08.010.

4.

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

Fu A, Ng AC, Depatie C, Wijesekara N, He Y, Wang GS, Bardeesy N, Scott FW, Touyz RM, Wheeler MB, Screaton RA.

Cell Metab. 2009 Oct;10(4):285-95. doi: 10.1016/j.cmet.2009.08.008.

5.

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.

Shackelford DB, Shaw RJ.

Nat Rev Cancer. 2009 Aug;9(8):563-75. doi: 10.1038/nrc2676.

6.

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis.

Holland AJ, Cleveland DW.

Nat Rev Mol Cell Biol. 2009 Jul;10(7):478-87. doi: 10.1038/nrm2718. Review.

7.

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J.

Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813.

8.

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

Shorning BY, Zabkiewicz J, McCarthy A, Pearson HB, Winton DJ, Sansom OJ, Ashworth A, Clarke AR.

PLoS One. 2009;4(1):e4264. doi: 10.1371/journal.pone.0004264. Epub 2009 Jan 23. Erratum in: PLoS One.2009;4(2). doi: 10.1371/annotation/7750701a-2069-4810-820b-b0a02b674a06.

9.

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ.

Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003.

10.

CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity.

Kiel MJ, Yilmaz OH, Morrison SJ.

Blood. 2008 Apr 15;111(8):4413-4; author reply 4414-5. doi: 10.1182/blood-2007-12-129601. No abstract available.

11.

FoxO transcription factors in the maintenance of cellular homeostasis during aging.

Salih DA, Brunet A.

Curr Opin Cell Biol. 2008 Apr;20(2):126-36. doi: 10.1016/j.ceb.2008.02.005. Epub 2008 Apr 3. Review.

12.

Lkb1 deficiency causes prostate neoplasia in the mouse.

Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR.

Cancer Res. 2008 Apr 1;68(7):2223-32. doi: 10.1158/0008-5472.CAN-07-5169.

13.

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, Zediak VP, Velez M, Bhandoola A, Brown EJ.

Cell Stem Cell. 2007 Jun 7;1(1):113-26. doi: 10.1016/j.stem.2007.03.002.

14.

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.

Cell Stem Cell. 2007 Jun 7;1(1):101-12. doi: 10.1016/j.stem.2007.02.001.

15.

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN, Schorge JO, Broaddus RR, Wong KK, Bardeesy N, Castrillon DH.

Cancer Res. 2008 Feb 1;68(3):759-66. doi: 10.1158/0008-5472.CAN-07-5014.

16.

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA.

Mol Cell Biol. 2008 Apr;28(7):2414-25. doi: 10.1128/MCB.01621-07. Epub 2008 Jan 28.

17.

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.

Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N.

Cancer Res. 2008 Jan 1;68(1):55-63. doi: 10.1158/0008-5472.CAN-07-3225. Erratum in: Cancer Res. 2008 Apr 1;68(7):2549. Sahin, Ergun [added].

18.

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

Hardie DG.

Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85. Review.

PMID:
17712357
19.

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A.

J Biol Chem. 2007 Oct 12;282(41):30107-19. Epub 2007 Aug 20.

20.

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division.

Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, Gatti M.

Development. 2007 Jun;134(11):2183-93.

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