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Items: 1 to 20 of 27


Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes.

Adenuga D, Rahman I.

Arch Biochem Biophys. 2010 Jun 1;498(1):62-73. doi: 10.1016/ Epub 2010 Apr 11.


Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation.

Garbin U, Fratta Pasini A, Stranieri C, Cominacini M, Pasini A, Manfro S, Lugoboni F, Mozzini C, Guidi G, Faccini G, Cominacini L.

PLoS One. 2009 Dec 9;4(12):e8225. doi: 10.1371/journal.pone.0008225.


HDAC2: a critical factor in health and disease.

Krämer OH.

Trends Pharmacol Sci. 2009 Dec;30(12):647-55. doi: 10.1016/ Epub 2009 Nov 4. Review.


Glucocorticoid resistance in inflammatory diseases.

Barnes PJ, Adcock IM.

Lancet. 2009 May 30;373(9678):1905-17. doi: 10.1016/S0140-6736(09)60326-3. Review.


Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.

Sun Z, Chin YE, Zhang DD.

Mol Cell Biol. 2009 May;29(10):2658-72. doi: 10.1128/MCB.01639-08. Epub 2009 Mar 9.


Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke.

Adenuga D, Yao H, March TH, Seagrave J, Rahman I.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):464-73. doi: 10.1165/rcmb.2008-0255OC. Epub 2008 Oct 16.


Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema.

Goven D, Boutten A, Leçon-Malas V, Marchal-Sommé J, Amara N, Crestani B, Fournier M, Lesèche G, Soler P, Boczkowski J, Bonay M.

Thorax. 2008 Oct;63(10):916-24. doi: 10.1136/thx.2007.091181. Epub 2008 Jun 17.


Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S.

Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. doi: 10.1164/rccm.200803-380OC. Epub 2008 Jun 12. Erratum in: Am J Respir Crit Care Med. 2009 Apr 1;179(7):624. Retraction in: Am J Respir Crit Care Med. 2016 Feb 1;193(3):344.


Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice.

Southam DS, Ellis R, Wattie J, Young S, Inman MD.

Eur Respir J. 2008 Oct;32(4):970-8. doi: 10.1183/09031936.00125307. Epub 2008 May 28.


Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice.

Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1174-86. doi: 10.1152/ajplung.00439.2007. Epub 2008 Mar 28.


NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK.

Liu GH, Qu J, Shen X.

Biochim Biophys Acta. 2008 May;1783(5):713-27. doi: 10.1016/j.bbamcr.2008.01.002. Epub 2008 Jan 12.


Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice.

Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O'Reilly MA, Rahman I.

Am J Respir Cell Mol Biol. 2008 Jul;39(1):7-18. doi: 10.1165/rcmb.2007-0342OC. Epub 2008 Jan 31.


IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung.

Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):689-98. doi: 10.1165/rcmb.2007-0379OC. Epub 2008 Jan 31.


Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.

Zimmermann S, Kiefer F, Prudenziati M, Spiller C, Hansen J, Floss T, Wurst W, Minucci S, Göttlicher M.

Cancer Res. 2007 Oct 1;67(19):9047-54.


Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA.

Nat Med. 2007 Mar;13(3):324-31. Epub 2007 Feb 18.


Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung.

Tomaki M, Sugiura H, Koarai A, Komaki Y, Akita T, Matsumoto T, Nakanishi A, Ogawa H, Hattori T, Ichinose M.

Pulm Pharmacol Ther. 2007;20(5):596-605. Epub 2006 Jul 11.


Oxidative stress and redox regulation of lung inflammation in COPD.

Rahman I, Adcock IM.

Eur Respir J. 2006 Jul;28(1):219-42. Review.


Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.

Hew M, Bhavsar P, Torrego A, Meah S, Khorasani N, Barnes PJ, Adcock I, Chung KF.

Am J Respir Crit Care Med. 2006 Jul 15;174(2):134-41. Epub 2006 Apr 13.


Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.

Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I.

Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L46-57. Epub 2006 Feb 10.


Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S.

J Clin Invest. 2004 Nov;114(9):1248-59.

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