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PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15467-72. doi: 10.1073/pnas.1000462107. Epub 2010 Aug 17.


Protein kinase A is a target for aging and the aging heart.

Enns LC, Pettan-Brewer C, Ladiges W.

Aging (Albany NY). 2010 Apr;2(4):238-43.


Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC.

J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1221-31. doi: 10.1093/gerona/glp133. Epub 2009 Sep 23.


Disruption of protein kinase A in mice enhances healthy aging.

Enns LC, Morton JF, Treuting PR, Emond MJ, Wolf NS, Dai DF, McKnight GS, Rabinovitch PS, Ladiges WC.

PLoS One. 2009 Jun 18;4(6):e5963. doi: 10.1371/journal.pone.0005963. Erratum in: PLoS One. 2010;5(2) doi: 10.1371/annotation/c7cad2dc-1eca-487e-89ae-151a22d8a0b4. Dai, Dao-Fu [added].


Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects.

Mantovani G, Bondioni S, Alberti L, Gilardini L, Invitti C, Corbetta S, Zappa MA, Ferrero S, Lania AG, Bosari S, Beck-Peccoz P, Spada A.

Diabetes. 2009 Mar;58(3):620-6. doi: 10.2337/db08-0585. Epub 2008 Dec 18.


Validation of volume-pressure recording tail-cuff blood pressure measurements.

Feng M, Whitesall S, Zhang Y, Beibel M, D'Alecy L, DiPetrillo K.

Am J Hypertens. 2008 Dec;21(12):1288-91. doi: 10.1038/ajh.2008.301. Epub 2008 Oct 9.


Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit.

Oksvold MP, Funderud A, Kvissel AK, Skarpen E, Henanger H, Huitfeldt HS, Skålhegg BS, Ørstavik S.

BMC Cell Biol. 2008 Apr 1;9:16. doi: 10.1186/1471-2121-9-16.


Renin-angiotensin system blockade is renoprotective in immune complex-mediated glomerulonephritis.

Guo S, Kowalewska J, Wietecha TA, Iyoda M, Wang L, Yi K, Spencer M, Banas M, Alexandrescu S, Hudkins KL, Alpers CE.

J Am Soc Nephrol. 2008 Jun;19(6):1168-76. doi: 10.1681/ASN.2007050607. Epub 2008 Mar 12.


AKAP signaling complexes: getting to the heart of the matter.

McConnachie G, Langeberg LK, Scott JD.

Trends Mol Med. 2006 Jul;12(7):317-23. Epub 2006 Jun 30. Review.


Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation.

Liao Y, Asakura M, Takashima S, Kato H, Asano Y, Shintani Y, Minamino T, Tomoike H, Hori M, Kitakaze M.

Biochem Biophys Res Commun. 2005 Feb 25;327(4):1083-7.


Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.

Chang S, McKinsey TA, Zhang CL, Richardson JA, Hill JA, Olson EN.

Mol Cell Biol. 2004 Oct;24(19):8467-76.


Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods.

Whitesall SE, Hoff JB, Vollmer AP, D'Alecy LG.

Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2408-15. Epub 2004 Feb 12.


Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias.

Kass RS, Moss AJ.

J Clin Invest. 2003 Sep;112(6):810-5. Review.


Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.

Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, Ishikawa Y.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9986-90. Epub 2003 Aug 6.


Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation.

Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, Vatner SF, Ishikawa Y.

Circ Res. 2003 Aug 22;93(4):364-71. Epub 2003 Jul 17.


Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.

Chen X, Dai JC, Greenfield EM.

Am J Physiol Cell Physiol. 2002 Nov;283(5):C1432-40.


Molecular and behavioral effects of a null mutation in all PKA C beta isoforms.

Howe DG, Wiley JC, McKnight GS.

Mol Cell Neurosci. 2002 Jul;20(3):515-24.


Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats.

Zou Y, Yamazaki T, Nakagawa K, Yamada H, Iriguchi N, Toko H, Takano H, Akazawa H, Nagai R, Komuro I.

Hypertens Res. 2002 Jan;25(1):117-24.


Seven-transmembrane-spanning receptors and heart function.

Rockman HA, Koch WJ, Lefkowitz RJ.

Nature. 2002 Jan 10;415(6868):206-12. Review.

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