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Results: 1 to 20 of 29

1.

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.

van den Bout I, Divecha N.

J Cell Sci. 2009 Nov 1;122(Pt 21):3837-50. doi: 10.1242/jcs.056127. Review.

PMID:
19889969
[PubMed - indexed for MEDLINE]
Free Article
2.

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.

Viaud J, Peterson JR.

Mol Cancer Ther. 2009 Sep;8(9):2559-65. doi: 10.1158/1535-7163.MCT-09-0102. Epub 2009 Sep 1.

PMID:
19723886
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

PAK signaling in oncogenesis.

Molli PR, Li DQ, Murray BW, Rayala SK, Kumar R.

Oncogene. 2009 Jul 16;28(28):2545-55. doi: 10.1038/onc.2009.119. Epub 2009 May 25. Review.

PMID:
19465939
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Lipid activation of protein kinases.

Newton AC.

J Lipid Res. 2009 Apr;50 Suppl:S266-71. doi: 10.1194/jlr.R800064-JLR200. Epub 2008 Nov 24. Review.

PMID:
19033211
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.

Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR.

Chem Biol. 2008 Apr;15(4):322-31. doi: 10.1016/j.chembiol.2008.03.005.

PMID:
18420139
[PubMed - indexed for MEDLINE]
Free Article
6.

A tale of two Paks.

Arias-Romero LE, Chernoff J.

Biol Cell. 2008 Feb;100(2):97-108. doi: 10.1042/BC20070109. Review.

PMID:
18199048
[PubMed - indexed for MEDLINE]
7.

Identification of novel membrane-binding domains in multiple yeast Cdc42 effectors.

Takahashi S, Pryciak PM.

Mol Biol Cell. 2007 Dec;18(12):4945-56. Epub 2007 Oct 3.

PMID:
17914055
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Specificity profiling of Pak kinases allows identification of novel phosphorylation sites.

Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR.

J Biol Chem. 2007 May 25;282(21):15667-78. Epub 2007 Mar 28.

PMID:
17392278
[PubMed - indexed for MEDLINE]
Free Article
9.

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T.

Science. 2006 Dec 1;314(5804):1458-61. Epub 2006 Nov 9.

PMID:
17095657
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Phosphoinositides in cell regulation and membrane dynamics.

Di Paolo G, De Camilli P.

Nature. 2006 Oct 12;443(7112):651-7. Review.

PMID:
17035995
[PubMed - indexed for MEDLINE]
11.

Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.

Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J.

J Biol Chem. 2006 Nov 24;281(47):36443-53. Epub 2006 Oct 1.

PMID:
17012749
[PubMed - indexed for MEDLINE]
Free Article
12.

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T.

Nat Chem Biol. 2006 Jan;2(1):39-46. Epub 2005 Nov 20. Erratum in: Nat Chem Biol. 2006 Apr;2(4):221.

PMID:
16408091
[PubMed - indexed for MEDLINE]
13.

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.

Beeser A, Jaffer ZM, Hofmann C, Chernoff J.

J Biol Chem. 2005 Nov 4;280(44):36609-15. Epub 2005 Aug 29.

PMID:
16129686
[PubMed - indexed for MEDLINE]
Free Article
14.

A polybasic motif allows N-WASP to act as a sensor of PIP(2) density.

Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA.

Mol Cell. 2005 Jan 21;17(2):181-91.

PMID:
15664188
[PubMed - indexed for MEDLINE]
Free Article
15.

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK.

Nat Struct Mol Biol. 2004 Aug;11(8):747-55. Epub 2004 Jul 4.

PMID:
15235593
[PubMed - indexed for MEDLINE]
16.

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7618-23. Epub 2004 May 5.

PMID:
15128949
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.

Wild AC, Yu JW, Lemmon MA, Blumer KJ.

J Biol Chem. 2004 Apr 23;279(17):17101-10. Epub 2004 Feb 6.

PMID:
14766750
[PubMed - indexed for MEDLINE]
Free Article
18.

Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.

Doughman RL, Firestone AJ, Wojtasiak ML, Bunce MW, Anderson RA.

J Biol Chem. 2003 Jun 20;278(25):23036-45. Epub 2003 Apr 6.

PMID:
12682053
[PubMed - indexed for MEDLINE]
Free Article
19.

Biology of the p21-activated kinases.

Bokoch GM.

Annu Rev Biochem. 2003;72:743-81. Epub 2003 Mar 27. Review.

PMID:
12676796
[PubMed - indexed for MEDLINE]
20.

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.

Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW.

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9.

PMID:
11553809
[PubMed - indexed for MEDLINE]
Free PMC Article

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