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Results: 1 to 20 of 86

1.

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.

Gremer L, De Luca A, Merbitz-Zahradnik T, Dallapiccola B, Morlot S, Tartaglia M, Kutsche K, Ahmadian MR, Rosenberger G.

Hum Mol Genet. 2010 Mar 1;19(5):790-802. doi: 10.1093/hmg/ddp548. Epub 2009 Dec 8.

PMID:
19995790
[PubMed - indexed for MEDLINE]
Free Article
2.

A restricted spectrum of NRAS mutations causes Noonan syndrome.

Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M.

Nat Genet. 2010 Jan;42(1):27-9. doi: 10.1038/ng.497. Epub 2009 Dec 6.

PMID:
19966803
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation.

Tidyman WE, Rauen KA.

Curr Opin Genet Dev. 2009 Jun;19(3):230-6. doi: 10.1016/j.gde.2009.04.001. Epub 2009 May 19. Review.

PMID:
19467855
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Isoform-specific ras functions in development and cancer.

Quinlan MP, Settleman J.

Future Oncol. 2009 Feb;5(1):105-16. doi: 10.2217/14796694.5.1.105. Review.

PMID:
19243303
[PubMed - indexed for MEDLINE]
5.

Noonan syndrome caused by germline KRAS mutation in Taiwan: report of two patients and a review of the literature.

Lo FS, Lin JL, Kuo MT, Chiu PC, Shu SG, Chao MC, Lee YJ, Lin SP.

Eur J Pediatr. 2009 Aug;168(8):919-23. doi: 10.1007/s00431-008-0858-z. Epub 2008 Oct 29. Review.

PMID:
18958496
[PubMed - indexed for MEDLINE]
6.

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.

Gremer L, Gilsbach B, Ahmadian MR, Wittinghofer A.

Biol Chem. 2008 Sep;389(9):1163-71. doi: 10.1515/BC.2008.132.

PMID:
18713003
[PubMed - indexed for MEDLINE]
7.

Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.

Stieglitz B, Bee C, Schwarz D, Yildiz O, Moshnikova A, Khokhlatchev A, Herrmann C.

EMBO J. 2008 Jul 23;27(14):1995-2005. doi: 10.1038/emboj.2008.125. Epub 2008 Jul 3.

PMID:
18596699
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Ras oncogenes: split personalities.

Karnoub AE, Weinberg RA.

Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31. doi: 10.1038/nrm2438. Review.

PMID:
18568040
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.

Aoki Y, Niihori T, Narumi Y, Kure S, Matsubara Y.

Hum Mutat. 2008 Aug;29(8):992-1006. doi: 10.1002/humu.20748. Review.

PMID:
18470943
[PubMed - indexed for MEDLINE]
10.

The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.

Gasper R, Thomas C, Ahmadian MR, Wittinghofer A.

J Mol Biol. 2008 May 23;379(1):51-63. doi: 10.1016/j.jmb.2008.03.011. Epub 2008 Mar 14. Erratum in: J Mol Biol. 2011 Jan 28;405(4):1119.

PMID:
18440551
[PubMed - indexed for MEDLINE]
11.

A novel switch region regulates H-ras membrane orientation and signal output.

Abankwa D, Hanzal-Bayer M, Ariotti N, Plowman SJ, Gorfe AA, Parton RG, McCammon JA, Hancock JF.

EMBO J. 2008 Mar 5;27(5):727-35. doi: 10.1038/emboj.2008.10. Epub 2008 Feb 14.

PMID:
18273062
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf.

Buhrman G, Wink G, Mattos C.

Structure. 2007 Dec;15(12):1618-29.

PMID:
18073111
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.

Denayer E, Parret A, Chmara M, Schubbert S, Vogels A, Devriendt K, Frijns JP, Rybin V, de Ravel TJ, Shannon K, Cools J, Scheffzek K, Legius E.

Hum Mutat. 2008 Feb;29(2):232-9.

PMID:
17979197
[PubMed - indexed for MEDLINE]
14.

Biochemical and functional characterization of germ line KRAS mutations.

Schubbert S, Bollag G, Lyubynska N, Nguyen H, Kratz CP, Zenker M, Niemeyer CM, Molven A, Shannon K.

Mol Cell Biol. 2007 Nov;27(22):7765-70. Epub 2007 Sep 17.

PMID:
17875937
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.

Nava C, Hanna N, Michot C, Pereira S, Pouvreau N, Niihori T, Aoki Y, Matsubara Y, Arveiler B, Lacombe D, Pasmant E, Parfait B, Baumann C, Héron D, Sigaudy S, Toutain A, Rio M, Goldenberg A, Leheup B, Verloes A, Cavé H.

J Med Genet. 2007 Dec;44(12):763-71. Epub 2007 Aug 17.

PMID:
17704260
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.

Tanaka T, Williams RL, Rabbitts TH.

EMBO J. 2007 Jul 11;26(13):3250-9. Epub 2007 Jun 14.

PMID:
17568777
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

GEFs and GAPs: critical elements in the control of small G proteins.

Bos JL, Rehmann H, Wittinghofer A.

Cell. 2007 Jun 1;129(5):865-77. Review. Erratum in: Cell. 2007 Jul 27;130(2):385.

PMID:
17540168
[PubMed - indexed for MEDLINE]
Free Article
18.

Prenylation of Ras facilitates hSOS1-promoted nucleotide exchange, upon Ras binding to the regulatory site.

Pechlivanis M, Ringel R, Popkirova B, Kuhlmann J.

Biochemistry. 2007 May 8;46(18):5341-8. Epub 2007 Apr 17.

PMID:
17437339
[PubMed - indexed for MEDLINE]
19.

Hyperactive Ras in developmental disorders and cancer.

Schubbert S, Shannon K, Bollag G.

Nat Rev Cancer. 2007 Apr;7(4):295-308. Review. Erratum in: Nat Rev Cancer. 2007 Jul;7(7):563.

PMID:
17384584
[PubMed - indexed for MEDLINE]
20.

An unexpected new role of mutant Ras: perturbation of human embryonic development.

Kratz CP, Niemeyer CM, Zenker M.

J Mol Med (Berl). 2007 Mar;85(3):227-35. Epub 2007 Jan 9. Review.

PMID:
17211612
[PubMed - indexed for MEDLINE]
Free PMC Article

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