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Results: 1 to 20 of 35

1.

Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells has caused serious adverse events.

Büning H, Uckert W, Cichutek K, Hawkins RE, Abken H.

Hum Gene Ther. 2010 Sep;21(9):1039-42. doi: 10.1089/hum.2010.131. No abstract available.

PMID:
20626322
[PubMed - indexed for MEDLINE]
2.

Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.

Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M.

Mol Ther. 2010 Apr;18(4):666-8. doi: 10.1038/mt.2010.31. No abstract available.

PMID:
20357779
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Safer CARS.

Heslop HE.

Mol Ther. 2010 Apr;18(4):661-2. doi: 10.1038/mt.2010.42. No abstract available.

PMID:
20357776
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Development and application of a multiplexable flow cytometry-based assay to quantify cell-mediated cytolysis.

Cao LF, Krymskaya L, Tran V, Mi S, Jensen MC, Blanchard S, Kalos M.

Cytometry A. 2010 Jun;77(6):534-45. doi: 10.1002/cyto.a.20887.

PMID:
20229499
[PubMed - indexed for MEDLINE]
Free Article
5.

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.

Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA.

Mol Ther. 2010 Apr;18(4):843-51. doi: 10.1038/mt.2010.24. Epub 2010 Feb 23.

PMID:
20179677
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Engineering lymphocyte subsets: tools, trials and tribulations.

June CH, Blazar BR, Riley JL.

Nat Rev Immunol. 2009 Oct;9(10):704-16. doi: 10.1038/nri2635. Review.

PMID:
19859065
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.

Zhao Y, Wang QJ, Yang S, Kochenderfer JN, Zheng Z, Zhong X, Sadelain M, Eshhar Z, Rosenberg SA, Morgan RA.

J Immunol. 2009 Nov 1;183(9):5563-74. doi: 10.4049/jimmunol.0900447.

PMID:
19843940
[PubMed - indexed for MEDLINE]
Free Article
8.

Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication.

Zhong XS, Matsushita M, Plotkin J, Riviere I, Sadelain M.

Mol Ther. 2010 Feb;18(2):413-20. doi: 10.1038/mt.2009.210. Epub 2009 Sep 22.

PMID:
19773745
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method.

Li L, Liu LN, Feller S, Allen C, Shivakumar R, Fratantoni J, Wolfraim LA, Fujisaki H, Campana D, Chopas N, Dzekunov S, Peshwa M.

Cancer Gene Ther. 2010 Mar;17(3):147-54. doi: 10.1038/cgt.2009.61. Epub 2009 Sep 11.

PMID:
19745843
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo.

Milone MC, Fish JD, Carpenito C, Carroll RG, Binder GK, Teachey D, Samanta M, Lakhal M, Gloss B, Danet-Desnoyers G, Campana D, Riley JL, Grupp SA, June CH.

Mol Ther. 2009 Aug;17(8):1453-64. doi: 10.1038/mt.2009.83. Epub 2009 Apr 21.

PMID:
19384291
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The promise and potential pitfalls of chimeric antigen receptors.

Sadelain M, Brentjens R, Rivière I.

Curr Opin Immunol. 2009 Apr;21(2):215-23. doi: 10.1016/j.coi.2009.02.009. Epub 2009 Mar 25. Review.

PMID:
19327974
[PubMed - indexed for MEDLINE]
12.

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3360-5. doi: 10.1073/pnas.0813101106. Epub 2009 Feb 11.

PMID:
19211796
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model.

Yoon SH, Lee JM, Cho HI, Kim EK, Kim HS, Park MY, Kim TG.

Cancer Gene Ther. 2009 Jun;16(6):489-97. doi: 10.1038/cgt.2008.98. Epub 2008 Dec 19.

PMID:
19096447
[PubMed - indexed for MEDLINE]
14.

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.

Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, Huls MH, Liu E, Gee AP, Mei Z, Yvon E, Weiss HL, Liu H, Rooney CM, Heslop HE, Brenner MK.

Nat Med. 2008 Nov;14(11):1264-70. doi: 10.1038/nm.1882. Epub 2008 Nov 2.

PMID:
18978797
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia.

Teachey DT, Sheen C, Hall J, Ryan T, Brown VI, Fish J, Reid GS, Seif AE, Norris R, Chang YJ, Carroll M, Grupp SA.

Blood. 2008 Sep 1;112(5):2020-3. doi: 10.1182/blood-2008-02-137141. Epub 2008 Jun 10.

PMID:
18544682
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells.

Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA, Qian X, James SE, Raubitschek A, Forman SJ, Gopal AK, Pagel JM, Lindgren CG, Greenberg PD, Riddell SR, Press OW.

Blood. 2008 Sep 15;112(6):2261-71. doi: 10.1182/blood-2007-12-128843. Epub 2008 May 28.

PMID:
18509084
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Selective modification of antigen-specific T cells by RNA electroporation.

Mitchell DA, Karikari I, Cui X, Xie W, Schmittling R, Sampson JH.

Hum Gene Ther. 2008 May;19(5):511-21. doi: 10.1089/hum.2007.115.

PMID:
18471037
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system.

Singh H, Manuri PR, Olivares S, Dara N, Dawson MJ, Huls H, Hackett PB, Kohn DB, Shpall EJ, Champlin RE, Cooper LJ.

Cancer Res. 2008 Apr 15;68(8):2961-71. doi: 10.1158/0008-5472.CAN-07-5600.

PMID:
18413766
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Adoptive cell transfer: a clinical path to effective cancer immunotherapy.

Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME.

Nat Rev Cancer. 2008 Apr;8(4):299-308. doi: 10.1038/nrc2355. Review.

PMID:
18354418
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Retroviral integration and human gene therapy.

Bushman FD.

J Clin Invest. 2007 Aug;117(8):2083-6.

PMID:
17671645
[PubMed - indexed for MEDLINE]
Free PMC Article

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