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Items: 1 to 20 of 48

1.

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.

PLoS One. 2010 Apr 1;5(4):e9979. doi: 10.1371/journal.pone.0009979. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/05c1b976-7eab-4154-808d-0526e604b8eb.

2.

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H.

J Neurosci. 2010 Apr 7;30(14):4845-56. doi: 10.1523/JNEUROSCI.5825-09.2010.

3.

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Caccamo A, Majumder S, Richardson A, Strong R, Oddo S.

J Biol Chem. 2010 Apr 23;285(17):13107-20. doi: 10.1074/jbc.M110.100420. Epub 2010 Feb 23.

4.

Alzheimer's disease.

Querfurth HW, LaFerla FM.

N Engl J Med. 2010 Jan 28;362(4):329-44. doi: 10.1056/NEJMra0909142. Review. No abstract available. Erratum in: N Engl J Med. 2011 Feb 10;364(6):588.

PMID:
20107219
5.

Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model.

Wesson DW, Levy E, Nixon RA, Wilson DA.

J Neurosci. 2010 Jan 13;30(2):505-14. doi: 10.1523/JNEUROSCI.4622-09.2010.

6.

The late endosome is essential for mTORC1 signaling.

Flinn RJ, Yan Y, Goswami S, Parker PJ, Backer JM.

Mol Biol Cell. 2010 Mar 1;21(5):833-41. doi: 10.1091/mbc.E09-09-0756. Epub 2010 Jan 6.

7.

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.

Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A.

Cell. 2009 Dec 11;139(6):1157-69. doi: 10.1016/j.cell.2009.11.014.

8.

mTOR signaling: at the crossroads of plasticity, memory and disease.

Hoeffer CA, Klann E.

Trends Neurosci. 2010 Feb;33(2):67-75. doi: 10.1016/j.tins.2009.11.003. Epub 2009 Dec 4. Review.

9.

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.

10.

GSK3: a possible link between beta amyloid peptide and tau protein.

Hernández F, Gómez de Barreda E, Fuster-Matanzo A, Lucas JJ, Avila J.

Exp Neurol. 2010 Jun;223(2):322-5. doi: 10.1016/j.expneurol.2009.09.011. Epub 2009 Sep 24. Review.

PMID:
19782073
11.

Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.

Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK.

J Neurosci. 2009 Aug 5;29(31):9704-13. doi: 10.1523/JNEUROSCI.2292-09.2009.

12.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA.

Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.

13.

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers.

De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7678.

14.

Translational control of long-lasting synaptic plasticity and memory.

Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N.

Neuron. 2009 Jan 15;61(1):10-26. doi: 10.1016/j.neuron.2008.10.055. Review.

15.

The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid.

Lee HK, Kumar P, Fu Q, Rosen KM, Querfurth HW.

Mol Biol Cell. 2009 Mar;20(5):1533-44. doi: 10.1091/mbc.E08-07-0777. Epub 2009 Jan 14.

16.

Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior.

Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E.

Neuron. 2008 Dec 10;60(5):832-45. doi: 10.1016/j.neuron.2008.09.037.

17.

GSK-3beta is required for memory reconsolidation in adult brain.

Kimura T, Yamashita S, Nakao S, Park JM, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, Takashima A.

PLoS One. 2008;3(10):e3540. doi: 10.1371/journal.pone.0003540. Epub 2008 Oct 28.

18.

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.

Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA.

J Neurosci. 2008 Jul 2;28(27):6926-37. doi: 10.1523/JNEUROSCI.0800-08.2008.

19.

Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells.

Gobert D, Topolnik L, Azzi M, Huang L, Badeaux F, Desgroseillers L, Sossin WS, Lacaille JC.

J Neurochem. 2008 Aug;106(3):1160-74. doi: 10.1111/j.1471-4159.2008.05470.x. Epub 2008 May 9.

20.

The role of GSK-3 in synaptic plasticity.

Peineau S, Bradley C, Taghibiglou C, Doherty A, Bortolotto ZA, Wang YT, Collingridge GL.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S428-37. doi: 10.1038/bjp.2008.2. Review.

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