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Items: 1 to 20 of 50

1.

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H.

J Biol Chem. 2010 Oct 1;285(40):30598-605. doi: 10.1074/jbc.M110.137729. Epub 2010 Aug 6.

2.

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H.

J Neurosci. 2009 Sep 2;29(35):10788-801. doi: 10.1523/JNEUROSCI.2132-09.2009.

3.

Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.

Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW.

J Neurosci. 2009 Jun 10;29(23):7459-73. doi: 10.1523/JNEUROSCI.4872-08.2009.

4.

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.

Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.

Nature. 2009 Feb 19;457(7232):981-9. doi: 10.1038/nature07767.

5.

Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production.

Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, Bredesen DE, Mehlen P.

Cell Death Differ. 2009 May;16(5):655-63. doi: 10.1038/cdd.2008.191. Epub 2009 Jan 16.

6.

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.

Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J.

J Neurosci. 2008 Nov 12;28(46):12097-106. doi: 10.1523/JNEUROSCI.2635-08.2008.

7.

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role.

Giliberto L, Zhou D, Weldon R, Tamagno E, De Luca P, Tabaton M, D'Adamio L.

Mol Neurodegener. 2008 Sep 2;3:12. doi: 10.1186/1750-1326-3-12.

8.

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ.

Neural Dev. 2008 Jun 23;3:15. doi: 10.1186/1749-8104-3-15.

9.

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.

Buxbaum JN, Ye Z, Reixach N, Friske L, Levy C, Das P, Golde T, Masliah E, Roberts AR, Bartfai T.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2681-6. doi: 10.1073/pnas.0712197105. Epub 2008 Feb 12.

10.

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G.

Neuron. 2007 Oct 4;56(1):66-78.

11.

Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.

Repetto E, Yoon IS, Zheng H, Kang DE.

J Biol Chem. 2007 Oct 26;282(43):31504-16. Epub 2007 Aug 23.

12.

Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter.

Wang B, Yang L, Wang Z, Zheng H.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14140-5. Epub 2007 Aug 20.

13.

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC.

J Neurosci. 2007 Jul 18;27(29):7817-26.

14.

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS.

J Neurosci. 2007 Jun 27;27(26):7006-10.

15.

alpha-Klotho as a regulator of calcium homeostasis.

Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T, Nabeshima Y.

Science. 2007 Jun 15;316(5831):1615-8.

16.

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.

Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10613-8. Epub 2007 Jun 7.

17.

beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment.

Back S, Haas P, Tschäpe JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, Kins S.

J Neurosci Res. 2007 Sep;85(12):2580-90.

PMID:
17335075
19.

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.

Hornsten A, Lieberthal J, Fadia S, Malins R, Ha L, Xu X, Daigle I, Markowitz M, O'Connor G, Plasterk R, Li C.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1971-6. Epub 2007 Jan 31.

20.

The amyloid precursor protein: beyond amyloid.

Zheng H, Koo EH.

Mol Neurodegener. 2006 Jul 3;1:5.

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