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Results: 1 to 20 of 47

1.

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity.

Raspe M, Gillis J, Krol H, Krom S, Bosch K, van Veen H, Reits E.

J Cell Sci. 2009 Sep 15;122(Pt 18):3262-71. doi: 10.1242/jcs.045567. Epub 2009 Aug 18.

PMID:
19690053
[PubMed - indexed for MEDLINE]
Free Article
2.

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC.

Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79.

PMID:
18391949
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.

Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL.

J Immunol. 2008 Feb 1;180(3):1704-12.

PMID:
18209067
[PubMed - indexed for MEDLINE]
Free Article
4.

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL.

Cell Metab. 2007 Dec;6(6):472-83.

PMID:
18054316
[PubMed - indexed for MEDLINE]
Free Article
5.

Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation.

Bhutani N, Venkatraman P, Goldberg AL.

EMBO J. 2007 Mar 7;26(5):1385-96. Epub 2007 Feb 22.

PMID:
17318184
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC.

J Biol Chem. 2007 Feb 23;282(8):5641-52. Epub 2006 Dec 20.

PMID:
17182613
[PubMed - indexed for MEDLINE]
Free Article
7.

Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro.

Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI.

Biochemistry. 2006 Dec 19;45(50):15111-9.

PMID:
17154549
[PubMed - indexed for MEDLINE]
8.

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.

Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC.

Curr Top Dev Biol. 2006;76:89-101. Review.

PMID:
17118264
[PubMed - indexed for MEDLINE]
9.

A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.

Karsten SL, Sang TK, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, Schulz C, Hui KS, Wiedau-Pazos M, Vinters HV, Binder LI, Geschwind DH, Jackson GR.

Neuron. 2006 Sep 7;51(5):549-60.

PMID:
16950154
[PubMed - indexed for MEDLINE]
Free Article
10.

Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome.

Kabuta T, Suzuki Y, Wada K.

J Biol Chem. 2006 Oct 13;281(41):30524-33. Epub 2006 Aug 18.

PMID:
16920710
[PubMed - indexed for MEDLINE]
Free Article
11.

Loss of autophagy in the central nervous system causes neurodegeneration in mice.

Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K.

Nature. 2006 Jun 15;441(7095):880-4. Epub 2006 Apr 19.

PMID:
16625205
[PubMed - indexed for MEDLINE]
12.

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.

Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J.

J Biol Chem. 2006 May 19;281(20):14474-85. Epub 2006 Mar 6.

PMID:
16522639
[PubMed - indexed for MEDLINE]
Free Article
13.

Rapamycin pre-treatment protects against apoptosis.

Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2006 Apr 1;15(7):1209-16. Epub 2006 Feb 23.

PMID:
16497721
[PubMed - indexed for MEDLINE]
Free Article
14.

Rapamycin alleviates toxicity of different aggregate-prone proteins.

Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2006 Feb 1;15(3):433-42. Epub 2005 Dec 20.

PMID:
16368705
[PubMed - indexed for MEDLINE]
Free Article
15.

Inefficient degradation of truncated polyglutamine proteins by the proteasome.

Holmberg CI, Staniszewski KE, Mensah KN, Matouschek A, Morimoto RI.

EMBO J. 2004 Oct 27;23(21):4307-18. Epub 2004 Oct 7.

PMID:
15470501
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.

Saric T, Graef CI, Goldberg AL.

J Biol Chem. 2004 Nov 5;279(45):46723-32. Epub 2004 Aug 24.

PMID:
15328361
[PubMed - indexed for MEDLINE]
Free Article
17.

The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster.

Ryder E, Blows F, Ashburner M, Bautista-Llacer R, Coulson D, Drummond J, Webster J, Gubb D, Gunton N, Johnson G, O'Kane CJ, Huen D, Sharma P, Asztalos Z, Baisch H, Schulze J, Kube M, Kittlaus K, Reuter G, Maroy P, Szidonya J, Rasmuson-Lestander A, Ekström K, Dickson B, Hugentobler C, Stocker H, Hafen E, Lepesant JA, Pflugfelder G, Heisenberg M, Mechler B, Serras F, Corominas M, Schneuwly S, Preat T, Roote J, Russell S.

Genetics. 2004 Jun;167(2):797-813.

PMID:
15238529
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC.

Nat Genet. 2004 Jun;36(6):585-95. Epub 2004 May 16.

PMID:
15146184
[PubMed - indexed for MEDLINE]
19.

A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

Reits E, Neijssen J, Herberts C, Benckhuijsen W, Janssen L, Drijfhout JW, Neefjes J.

Immunity. 2004 Apr;20(4):495-506.

PMID:
15084277
[PubMed - indexed for MEDLINE]
20.

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL.

Mol Cell. 2004 Apr 9;14(1):95-104.

PMID:
15068806
[PubMed - indexed for MEDLINE]
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