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Items: 1 to 20 of 62


High-throughput discovery of broad-spectrum peptide antibiotics.

Rathinakumar R, Wimley WC.

FASEB J. 2010 Sep;24(9):3232-8. doi: 10.1096/fj.10-157040. Epub 2010 Apr 21.


Probing the "charge cluster mechanism" in amphipathic helical cationic antimicrobial peptides.

Epand RF, Maloy WL, Ramamoorthy A, Epand RM.

Biochemistry. 2010 May 18;49(19):4076-84. doi: 10.1021/bi100378m.


Revealing the lytic mechanism of the antimicrobial peptide gomesin by observing giant unilamellar vesicles.

Domingues TM, Riske KA, Miranda A.

Langmuir. 2010 Jul 6;26(13):11077-84. doi: 10.1021/la100662a.


Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics.

Almeida PF, Pokorny A.

Biochemistry. 2009 Sep 1;48(34):8083-93. doi: 10.1021/bi900914g.


Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers.

Yesylevskyy S, Marrink SJ, Mark AE.

Biophys J. 2009 Jul 8;97(1):40-9. doi: 10.1016/j.bpj.2009.03.059.


Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity.

Rathinakumar R, Walkenhorst WF, Wimley WC.

J Am Chem Soc. 2009 Jun 10;131(22):7609-17. doi: 10.1021/ja8093247.


Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics.

Heitz F, Morris MC, Divita G.

Br J Pharmacol. 2009 May;157(2):195-206. doi: 10.1111/j.1476-5381.2009.00057.x. Epub 2009 Mar 20. Review.


Magainin 2-induced pore formation in the lipid membranes depends on its concentration in the membrane interface.

Tamba Y, Yamazaki M.

J Phys Chem B. 2009 Apr 9;113(14):4846-52. doi: 10.1021/jp8109622.


Magainin 2 revisited: a test of the quantitative model for the all-or-none permeabilization of phospholipid vesicles.

Gregory SM, Pokorny A, Almeida PF.

Biophys J. 2009 Jan;96(1):116-31. doi: 10.1016/j.bpj.2008.09.017.


A peptide fragment derived from the T-cell antigen receptor protein alpha-chain adopts beta-sheet structure and shows potent antimicrobial activity.

Zhang G, Lin X, Long Y, Wang Y, Zhang Y, Mi H, Yan H.

Peptides. 2009 Apr;30(4):647-53. doi: 10.1016/j.peptides.2008.12.002. Epub 2008 Dec 6.


The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis.

Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M.

J Antimicrob Chemother. 2009 Jan;63(1):115-23. doi: 10.1093/jac/dkn436. Epub 2008 Oct 27.


Control of cell selectivity of antimicrobial peptides.

Matsuzaki K.

Biochim Biophys Acta. 2009 Aug;1788(8):1687-92. doi: 10.1016/j.bbamem.2008.09.013. Epub 2008 Oct 8. Review.


Lipid domains in bacterial membranes and the action of antimicrobial agents.

Epand RM, Epand RF.

Biochim Biophys Acta. 2009 Jan;1788(1):289-94. doi: 10.1016/j.bbamem.2008.08.023. Epub 2008 Sep 10. Review.


The activity of the amphipathic peptide delta-lysin correlates with phospholipid acyl chain structure and bilayer elastic properties.

Pokorny A, Kilelee EM, Wu D, Almeida PF.

Biophys J. 2008 Nov 15;95(10):4748-55. doi: 10.1529/biophysj.108.138701. Epub 2008 Aug 15.


Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes.

Rathinakumar R, Wimley WC.

J Am Chem Soc. 2008 Jul 30;130(30):9849-58. doi: 10.1021/ja8017863. Epub 2008 Jul 9.


Toroidal pores formed by antimicrobial peptides show significant disorder.

Sengupta D, Leontiadou H, Mark AE, Marrink SJ.

Biochim Biophys Acta. 2008 Oct;1778(10):2308-17. doi: 10.1016/j.bbamem.2008.06.007. Epub 2008 Jun 18.


Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances.

Wiegand I, Hilpert K, Hancock RE.

Nat Protoc. 2008;3(2):163-75. doi: 10.1038/nprot.2007.521.


Structure of the alamethicin pore reconstructed by x-ray diffraction analysis.

Qian S, Wang W, Yang L, Huang HW.

Biophys J. 2008 May 1;94(9):3512-22. doi: 10.1529/biophysj.107.126474. Epub 2008 Jan 16.


Mimicry of antimicrobial host-defense peptides by random copolymers.

Mowery BP, Lee SE, Kissounko DA, Epand RF, Epand RM, Weisblum B, Stahl SS, Gellman SH.

J Am Chem Soc. 2007 Dec 19;129(50):15474-6. Epub 2007 Nov 23. No abstract available.


A quantitative model for the all-or-none permeabilization of phospholipid vesicles by the antimicrobial peptide cecropin A.

Gregory SM, Cavenaugh A, Journigan V, Pokorny A, Almeida PF.

Biophys J. 2008 Mar 1;94(5):1667-80. Epub 2007 Oct 5.

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