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Results: 1 to 20 of 62

1.

Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

Wang L, Martin B, Brenneman R, Luttrell LM, Maudsley S.

J Pharmacol Exp Ther. 2009 Nov;331(2):340-8. doi: 10.1124/jpet.109.156380. Epub 2009 Aug 10. Review.

PMID:
19667132
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Autoimmune mediated G-protein receptor activation in cardiovascular and renal pathologies.

Dragun D, Philippe A, Catar R, Hegner B.

Thromb Haemost. 2009 Apr;101(4):643-8. Review.

PMID:
19350106
[PubMed - indexed for MEDLINE]
3.

Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers.

Berque-Bestel I, Lezoualc'h F, Jockers R.

Curr Drug Discov Technol. 2008 Dec;5(4):312-8. Review.

PMID:
19075611
[PubMed - indexed for MEDLINE]
4.

Multiple ligands in opioid research.

Ballet S, Pietsch M, Abell AD.

Protein Pept Lett. 2008;15(7):668-82. Review.

PMID:
18782061
[PubMed - indexed for MEDLINE]
5.

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.

Brady AE, Jones CK, Bridges TM, Kennedy JP, Thompson AD, Heiman JU, Breininger ML, Gentry PR, Yin H, Jadhav SB, Shirey JK, Conn PJ, Lindsley CW.

J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. doi: 10.1124/jpet.108.140350. Epub 2008 Sep 4.

PMID:
18772318
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Antibodies against G-protein coupled receptors: novel uses in screening and drug development.

Gupta A, Heimann AS, Gomes I, Devi LA.

Comb Chem High Throughput Screen. 2008 Jul;11(6):463-7. Review.

PMID:
18673273
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Identification of a serotonin/glutamate receptor complex implicated in psychosis.

González-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, López-Giménez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC.

Nature. 2008 Mar 6;452(7183):93-7. doi: 10.1038/nature06612. Epub 2008 Feb 24.

PMID:
18297054
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies.

Gupta A, Rozenfeld R, Gomes I, Raehal KM, Décaillot FM, Bohn LM, Devi LA.

J Biol Chem. 2008 Apr 18;283(16):10735-44. doi: 10.1074/jbc.M709454200. Epub 2008 Feb 6.

PMID:
18256033
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Hemopressin is an inverse agonist of CB1 cannabinoid receptors.

Heimann AS, Gomes I, Dale CS, Pagano RL, Gupta A, de Souza LL, Luchessi AD, Castro LM, Giorgi R, Rioli V, Ferro ES, Devi LA.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20588-93. Epub 2007 Dec 12.

PMID:
18077343
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Humanization of antibodies.

Almagro JC, Fransson J.

Front Biosci. 2008 Jan 1;13:1619-33. Review.

PMID:
17981654
[PubMed - indexed for MEDLINE]
11.

Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists.

Abul-Husn NS, Sutak M, Milne B, Jhamandas K.

Br J Pharmacol. 2007 Jul;151(6):877-87. Epub 2007 May 14.

PMID:
17502848
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Conformation state-sensitive antibodies to G-protein-coupled receptors.

Gupta A, Décaillot FM, Gomes I, Tkalych O, Heimann AS, Ferro ES, Devi LA.

J Biol Chem. 2007 Feb 23;282(8):5116-24. Epub 2006 Dec 4.

PMID:
17148456
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis.

Rios C, Gomes I, Devi LA.

Br J Pharmacol. 2006 Jun;148(4):387-95. Epub 2006 May 8.

PMID:
16682964
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.

McGraw DW, Mihlbachler KA, Schwarb MR, Rahman FF, Small KM, Almoosa KF, Liggett SB.

J Clin Invest. 2006 May;116(5):1400-9.

PMID:
16670773
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Potent antibody therapeutics by design.

Carter PJ.

Nat Rev Immunol. 2006 May;6(5):343-57. Review.

PMID:
16622479
[PubMed - indexed for MEDLINE]
16.

Targeting opioid receptor heterodimers: strategies for screening and drug development.

Gupta A, Décaillot FM, Devi LA.

AAPS J. 2006 Mar 10;8(1):E153-9. Review.

PMID:
16584123
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.

Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19208-13. Epub 2005 Dec 19.

PMID:
16365317
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells.

Xie Z, Bhushan RG, Daniels DJ, Portoghese PS.

Mol Pharmacol. 2005 Oct;68(4):1079-86. Epub 2005 Jul 8.

PMID:
16006595
[PubMed - indexed for MEDLINE]
Free Article
19.

Allosteric functioning of dimeric class C G-protein-coupled receptors.

Pin JP, Kniazeff J, Liu J, Binet V, Goudet C, Rondard P, Prézeau L.

FEBS J. 2005 Jun;272(12):2947-55. Review.

PMID:
15955055
[PubMed - indexed for MEDLINE]
Free Article
20.

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation.

Bulenger S, Marullo S, Bouvier M.

Trends Pharmacol Sci. 2005 Mar;26(3):131-7. Review.

PMID:
15749158
[PubMed - indexed for MEDLINE]

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