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Results: 1 to 20 of 38

1.

Membrane transporters in drug development.

International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L.

Nat Rev Drug Discov. 2010 Mar;9(3):215-36. doi: 10.1038/nrd3028. Review.

PMID:
20190787
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4).

Zhou F, Zhu L, Cui PH, Church WB, Murray M.

Br J Pharmacol. 2010 Jan 1;159(2):419-27. doi: 10.1111/j.1476-5381.2009.00545.x. Epub 2009 Dec 10.

PMID:
20015291
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.

van der Harst P, Bakker SJ, de Boer RA, Wolffenbuttel BH, Johnson T, Caulfield MJ, Navis G.

Hum Mol Genet. 2010 Jan 15;19(2):387-95. doi: 10.1093/hmg/ddp489. Epub 2009 Oct 27.

PMID:
19861489
[PubMed - indexed for MEDLINE]
Free Article
4.

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H; EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI; ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H; PROCARDIS Consortium, Doering A, Wichmann HE; KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M; WTCCC, Illig T, Gieger C.

PLoS Genet. 2009 Jun;5(6):e1000504. doi: 10.1371/journal.pgen.1000504. Epub 2009 Jun 5.

PMID:
19503597
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural.

Bakhiya N, Monien B, Frank H, Seidel A, Glatt H.

Biochem Pharmacol. 2009 Aug 15;78(4):414-9. doi: 10.1016/j.bcp.2009.04.017. Epub 2009 Apr 24.

PMID:
19394312
[PubMed - indexed for MEDLINE]
6.

Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury.

Zhang R, Yang X, Li J, Wu J, Peng WX, Dong XQ, Zhou SF, Yu XQ.

Am J Nephrol. 2008;28(5):772-83. doi: 10.1159/000129073. Epub 2008 Apr 28.

PMID:
18441523
[PubMed - indexed for MEDLINE]
7.

Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients.

Lee WK, Kwak JO, Hwang JS, Suh CK, Cha SH.

Mol Cells. 2008 Apr 30;25(2):265-71. Epub 2008 Mar 31.

PMID:
18414001
[PubMed - indexed for MEDLINE]
Free Article
8.

Roles of organic anion transporters in the progression of chronic renal failure.

Enomoto A, Niwa T.

Ther Apher Dial. 2007 Oct;11 Suppl 1:S27-31. Review.

PMID:
17976081
[PubMed - indexed for MEDLINE]
9.

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).

Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM.

Pharmacogenet Genomics. 2007 Sep;17(9):773-82.

PMID:
17700366
[PubMed - indexed for MEDLINE]
10.

SNAP: predict effect of non-synonymous polymorphisms on function.

Bromberg Y, Rost B.

Nucleic Acids Res. 2007;35(11):3823-35. Epub 2007 May 25.

PMID:
17526529
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J.

Drug Metab Dispos. 2007 Aug;35(8):1333-40. Epub 2007 May 11.

PMID:
17496207
[PubMed - indexed for MEDLINE]
Free Article
12.

Human renal organic anion transporter 4 operates as an asymmetric urate transporter.

Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A.

J Am Soc Nephrol. 2007 Feb;18(2):430-9. Epub 2007 Jan 17.

PMID:
17229912
[PubMed - indexed for MEDLINE]
Free Article
13.

Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

Yamashita F, Ohtani H, Koyabu N, Ushigome F, Satoh H, Murakami H, Uchiumi T, Nakamura T, Kuwano M, Tsujimoto M, Sawada Y.

J Pharm Pharmacol. 2006 Nov;58(11):1499-505.

PMID:
17132213
[PubMed - indexed for MEDLINE]
14.

Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters.

Vormfelde SV, Schirmer M, Hagos Y, Toliat MR, Engelhardt S, Meineke I, Burckhardt G, Nürnberg P, Brockmöller J.

Br J Clin Pharmacol. 2006 Sep;62(3):323-35.

PMID:
16934049
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information.

Capriotti E, Calabrese R, Casadio R.

Bioinformatics. 2006 Nov 15;22(22):2729-34. Epub 2006 Aug 7.

PMID:
16895930
[PubMed - indexed for MEDLINE]
Free Article
16.

Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies.

Nishimura M, Naito S.

Drug Metab Pharmacokinet. 2005 Dec;20(6):452-77.

PMID:
16415531
[PubMed - indexed for MEDLINE]
Free Article
17.

Functional genomics of membrane transporters in human populations.

Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM.

Genome Res. 2006 Feb;16(2):223-30. Epub 2005 Dec 14.

PMID:
16354753
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.

Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM.

Am J Physiol Renal Physiol. 2006 Apr;290(4):F905-12. Epub 2005 Nov 15.

PMID:
16291576
[PubMed - indexed for MEDLINE]
Free Article
19.

Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells.

Zhou F, Illsley NP, You G.

Eur J Pharm Sci. 2006 Apr;27(5):518-23. Epub 2005 Oct 27.

PMID:
16257192
[PubMed - indexed for MEDLINE]
20.

Human renal organic anion transporters: characteristics and contributions to drug and drug metabolite excretion.

Robertson EE, Rankin GO.

Pharmacol Ther. 2006 Mar;109(3):399-412. Epub 2005 Sep 16. Review.

PMID:
16169085
[PubMed - indexed for MEDLINE]

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