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Items: 1 to 20 of 49


AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.

Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2009 Nov 25;36(4):631-41. doi: 10.1016/j.molcel.2009.11.007.


Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

Krijger PH, Langerak P, van den Berk PC, Jacobs H.

J Exp Med. 2009 Nov 23;206(12):2603-11. doi: 10.1084/jem.20091707. Epub 2009 Nov 9.


Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.

Storb U, Shen HM, Nicolae D.

Cell Cycle. 2009 Oct 1;8(19):3097-101. Epub 2009 Oct 29. No abstract available.


The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.

Frieder D, Larijani M, Collins C, Shulman M, Martin A.

Mol Cell Biol. 2009 Sep;29(18):5148-57. doi: 10.1128/MCB.00647-09. Epub 2009 Jul 13.


Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs.

Steele EJ.

Mol Immunol. 2009 Jan;46(3):305-20. doi: 10.1016/j.molimm.2008.10.021. Epub 2008 Dec 4. Review.


Competitive repair pathways in immunoglobulin gene hypermutation.

Reynaud CA, Delbos F, Faili A, Guéranger Q, Aoufouchi S, Weill JC.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):613-9. doi: 10.1098/rstb.2008.0206. Review.


SHMTool: a webserver for comparative analysis of somatic hypermutation datasets.

Maccarthy T, Roa S, Scharff MD, Bergman A.

DNA Repair (Amst). 2009 Jan 1;8(1):137-41. doi: 10.1016/j.dnarep.2008.09.006. Epub 2008 Nov 8.


Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16248-53. doi: 10.1073/pnas.0808182105. Epub 2008 Oct 14.


The strand bias paradox of somatic hypermutation at immunoglobulin loci.

Franklin A, Blanden RV.

Trends Immunol. 2008 Apr;29(4):167-72. doi: 10.1016/ Epub 2008 Mar 7.


The biochemistry of somatic hypermutation.

Peled JU, Kuang FL, Iglesias-Ussel MD, Roa S, Kalis SL, Goodman MF, Scharff MD.

Annu Rev Immunol. 2008;26:481-511. doi: 10.1146/annurev.immunol.26.021607.090236. Review.


Two levels of protection for the B cell genome during somatic hypermutation.

Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, Kleinstein SH, Schatz DG.

Nature. 2008 Feb 14;451(7180):841-5. doi: 10.1038/nature06547.


A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

Langerak P, Nygren AO, Krijger PH, van den Berk PC, Jacobs H.

J Exp Med. 2007 Aug 6;204(8):1989-98. Epub 2007 Jul 30.


Familial T-cell non-Hodgkin lymphoma caused by biallelic MSH2 mutations.

Scott RH, Homfray T, Huxter NL, Mitton SG, Nash R, Potter MN, Lancaster D, Rahman N.

J Med Genet. 2007 Jul;44(7):e83.


Multiple functions for the N-terminal region of Msh6.

Clark AB, Deterding L, Tomer KB, Kunkel TA.

Nucleic Acids Res. 2007;35(12):4114-23. Epub 2007 Jun 12.


Structure of the human MutSalpha DNA lesion recognition complex.

Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS.

Mol Cell. 2007 May 25;26(4):579-92.


The N terminus of Saccharomyces cerevisiae Msh6 is an unstructured tether to PCNA.

Shell SS, Putnam CD, Kolodner RD.

Mol Cell. 2007 May 25;26(4):565-78.


Molecular mechanisms of antibody somatic hypermutation.

Di Noia JM, Neuberger MS.

Annu Rev Biochem. 2007;76:1-22. Review.


Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.

Xiao Z, Ray M, Jiang C, Clark AB, Rogozin IB, Diaz M.

Mol Immunol. 2007 Apr;44(10):2659-66. Epub 2007 Jan 22.


DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

Delbos F, Aoufouchi S, Faili A, Weill JC, Reynaud CA.

J Exp Med. 2007 Jan 22;204(1):17-23. Epub 2006 Dec 26.


Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.

Shen HM, Tanaka A, Bozek G, Nicolae D, Storb U.

J Immunol. 2006 Oct 15;177(8):5386-92.

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