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Items: 14


Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

Mi L, Gan N, Chung FL.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):456-62. doi: 10.1016/j.bbrc.2009.08.047. Epub 2009 Aug 12.


Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

Mi L, Gan N, Cheema A, Dakshanamurthy S, Wang X, Yang DC, Chung FL.

J Biol Chem. 2009 Jun 19;284(25):17039-51. doi: 10.1074/jbc.M901789200. Epub 2009 Apr 1.


Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.

Shankar S, Ganapathy S, Srivastava RK.

Clin Cancer Res. 2008 Nov 1;14(21):6855-66. doi: 10.1158/1078-0432.CCR-08-0903.


Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis.

Mi L, Xiao Z, Hood BL, Dakshanamurthy S, Wang X, Govind S, Conrads TP, Veenstra TD, Chung FL.

J Biol Chem. 2008 Aug 8;283(32):22136-46. doi: 10.1074/jbc.M802330200. Epub 2008 Jun 3.


The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

Mi L, Wang X, Govind S, Hood BL, Veenstra TD, Conrads TP, Saha DT, Goldman R, Chung FL.

Cancer Res. 2007 Jul 1;67(13):6409-16.


Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P.

Cancer Cell. 2006 Sep;10(3):241-52.


N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.

Yang YM, Jhanwar-Uniyal M, Schwartz J, Conaway CC, Halicka HD, Traganos F, Chung FL.

Cancer Res. 2005 Sep 15;65(18):8538-47.


Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A.

J Biol Chem. 2005 May 20;280(20):19911-24. Epub 2005 Mar 11.


Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats.

Conaway CC, Jiao D, Kohri T, Liebes L, Chung FL.

Drug Metab Dispos. 1999 Jan;27(1):13-20.


Surrogate endpoint biomarkers for phase II cancer chemoprevention trials.

Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R, Doody LA.

J Cell Biochem Suppl. 1994;19:1-9. Review.


N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites.

Morgan LR, Holdiness MR, Gillen LE.

Semin Oncol. 1983 Mar;10(1 Suppl 1):56-61. No abstract available.


Reactions of cysteine, its derivatives, glutathione coenzyme A, and dihydrolipoic acid with isothiocyanates.

PodhradskĂ˝ D, Drobnica L, Kristian P.

Experientia. 1979 Feb 15;35(2):154-5.

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