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Results: 1 to 20 of 43

1.

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.

Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y.

J Pharmacol Exp Ther. 2010 Jun;333(3):788-96. doi: 10.1124/jpet.109.162321. Epub 2010 Mar 19.

PMID:
20304939
[PubMed - indexed for MEDLINE]
Free Article
2.

17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity.

Hartz AM, Mahringer A, Miller DS, Bauer B.

J Cereb Blood Flow Metab. 2010 Oct;30(10):1742-55. doi: 10.1038/jcbfm.2010.36. Epub 2010 Mar 10.

PMID:
20216549
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.

Rigor RR, Hawkins BT, Miller DS.

J Cereb Blood Flow Metab. 2010 Jul;30(7):1373-83. doi: 10.1038/jcbfm.2010.21. Epub 2010 Mar 3.

PMID:
20197783
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.

Hawkins BT, Sykes DB, Miller DS.

J Neurosci. 2010 Jan 27;30(4):1417-25. doi: 10.1523/JNEUROSCI.5103-09.2010.

PMID:
20107068
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Interaction of estrogen receptors with insulin-like growth factor-I and Wnt signaling in the nervous system.

Varea O, Arevalo MA, Garrido JJ, Garcia-Segura LM, Wandosell F, Mendez P.

Steroids. 2010 Aug-Sep;75(8-9):565-9. doi: 10.1016/j.steroids.2009.09.006. Epub 2009 Sep 22. Review.

PMID:
19778547
[PubMed - indexed for MEDLINE]
6.

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

Oh M, Kim H, Yang I, Park JH, Cong WT, Baek MC, Bareiss S, Ki H, Lu Q, No J, Kwon I, Choi JK, Kim K.

J Biol Chem. 2009 Oct 16;284(42):28579-89. doi: 10.1074/jbc.M109.002659. Epub 2009 Aug 25.

PMID:
19706605
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib.

Chen Y, Agarwal S, Shaik NM, Chen C, Yang Z, Elmquist WF.

J Pharmacol Exp Ther. 2009 Sep;330(3):956-63. doi: 10.1124/jpet.109.154781. Epub 2009 Jun 2.

PMID:
19491323
[PubMed - indexed for MEDLINE]
Free Article
8.

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.

Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC.

Cell Stem Cell. 2009 Mar 6;4(3):226-35. doi: 10.1016/j.stem.2009.01.007.

PMID:
19265662
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.

Zhou L, Schmidt K, Nelson FR, Zelesky V, Troutman MD, Feng B.

Drug Metab Dispos. 2009 May;37(5):946-55. doi: 10.1124/dmd.108.024489. Epub 2009 Feb 18.

PMID:
19225039
[PubMed - indexed for MEDLINE]
Free Article
10.

ABC transporters, drug resistance, and cancer stem cells.

Dean M.

J Mammary Gland Biol Neoplasia. 2009 Mar;14(1):3-9. doi: 10.1007/s10911-009-9109-9. Epub 2009 Feb 18. Review.

PMID:
19224345
[PubMed - indexed for MEDLINE]
11.

An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016).

Polli JW, Olson KL, Chism JP, John-Williams LS, Yeager RL, Woodard SM, Otto V, Castellino S, Demby VE.

Drug Metab Dispos. 2009 Feb;37(2):439-42. doi: 10.1124/dmd.108.024646. Epub 2008 Dec 4.

PMID:
19056914
[PubMed - indexed for MEDLINE]
Free Article
12.

Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice.

Shukla S, Zaher H, Hartz A, Bauer B, Ware JA, Ambudkar SV.

Pharm Res. 2009 Feb;26(2):480-7. doi: 10.1007/s11095-008-9735-8. Epub 2008 Oct 9.

PMID:
18841445
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier.

Hartz AM, Bauer B, Block ML, Hong JS, Miller DS.

FASEB J. 2008 Aug;22(8):2723-33. doi: 10.1096/fj.08-106997. Epub 2008 May 12.

PMID:
18474546
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Dynamic regulation of estrogen receptor-alpha gene expression in the brain: a role for promoter methylation?

Wilson ME, Westberry JM, Prewitt AK.

Front Neuroendocrinol. 2008 Jun;29(3):375-85. doi: 10.1016/j.yfrne.2008.03.002. Epub 2008 Mar 13. Review.

PMID:
18439661
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.

de Vries NA, Zhao J, Kroon E, Buckle T, Beijnen JH, van Tellingen O.

Clin Cancer Res. 2007 Nov 1;13(21):6440-9.

PMID:
17975156
[PubMed - indexed for MEDLINE]
Free Article
16.

Transcriptional upregulation of breast cancer resistance protein by 17beta-estradiol in ERalpha-positive MCF-7 breast cancer cells.

Zhang Y, Zhou G, Wang H, Zhang X, Wei F, Cai Y, Yin D.

Oncology. 2006;71(5-6):446-55. Epub 2007 Sep 17.

PMID:
17878748
[PubMed - indexed for MEDLINE]
17.

Hormonal regulation of BCRP expression in human placental BeWo cells.

Wang H, Unadkat JD, Mao Q.

Pharm Res. 2008 Feb;25(2):444-52. Epub 2007 Sep 6.

PMID:
17823853
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier.

Bauer B, Hartz AM, Miller DS.

Mol Pharmacol. 2007 Mar;71(3):667-75. Epub 2006 Nov 28.

PMID:
17132686
[PubMed - indexed for MEDLINE]
Free Article
19.

Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors.

Wang H, Wu X, Hudkins K, Mikheev A, Zhang H, Gupta A, Unadkat JD, Mao Q.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1295-304.

PMID:
17082346
[PubMed - indexed for MEDLINE]
Free Article
20.

Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.

Leung YK, Mak P, Hassan S, Ho SM.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13162-7. Epub 2006 Aug 22. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14977.

PMID:
16938840
[PubMed - indexed for MEDLINE]
Free PMC Article

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