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Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.

Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR.

Cell Metab. 2009 May;9(5):428-39. doi: 10.1016/j.cmet.2009.04.001. Erratum in: Cell Metab. 2009 Jun;9(6):565.


Pancreatic endocrine microadenomatosis in patients with von Hippel-Lindau disease: characterization by VHL/HIF pathway proteins expression.

Périgny M, Hammel P, Corcos O, Larochelle O, Giraud S, Richard S, Sauvanet A, Belghiti J, Ruszniewski P, Bedossa P, Couvelard A.

Am J Surg Pathol. 2009 May;33(5):739-48. doi: 10.1097/PAS.0b013e3181967992.


Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ.

J Clin Invest. 2009 Jan;119(1):125-35. doi: 10.1172/JCI26934. Epub 2008 Dec 8.


PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W.

Genes Dev. 2008 Nov 15;22(22):3135-46. doi: 10.1101/gad.496908.


A role for von Hippel-Lindau protein in pancreatic beta-cell function.

Puri S, Cano DA, Hebrok M.

Diabetes. 2009 Feb;58(2):433-41. doi: 10.2337/db08-0749. Epub 2008 Nov 25.


The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis.

Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL, Simon MC, Thompson CB.

Genes Dev. 2007 May 1;21(9):1037-49. Epub 2007 Apr 16.


HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.

Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL.

Cell. 2007 Apr 6;129(1):111-22.


HIF-1 and HIF-2: working alone or together in hypoxia?

Ratcliffe PJ.

J Clin Invest. 2007 Apr;117(4):862-5.


Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site.

Bonello S, Zähringer C, BelAiba RS, Djordjevic T, Hess J, Michiels C, Kietzmann T, Görlach A.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):755-61. Epub 2007 Feb 1.


Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase.

Biswas S, Gupta MK, Chattopadhyay D, Mukhopadhyay CK.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H758-66. Epub 2006 Nov 3.


Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.

Triantafyllou A, Liakos P, Tsakalof A, Georgatsou E, Simos G, Bonanou S.

Free Radic Res. 2006 Aug;40(8):847-56.


Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice.

Yim SH, Shah Y, Tomita S, Morris HD, Gavrilova O, Lambert G, Ward JM, Gonzalez FJ.

Hepatology. 2006 Sep;44(3):550-60.


Von Hippel-Lindau disease and endocrine tumour susceptibility.

Woodward ER, Maher ER.

Endocr Relat Cancer. 2006 Jun;13(2):415-25. Review.


HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC.

Cell Metab. 2006 Mar;3(3):187-97.


Association between serum ferritin and the insulin resistance syndrome in a representative population.

Wrede CE, Buettner R, Bollheimer LC, Schölmerich J, Palitzsch KD, Hellerbrand C.

Eur J Endocrinol. 2006 Feb;154(2):333-40.


Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.

Cowden Dahl KD, Fryer BH, Mack FA, Compernolle V, Maltepe E, Adelman DM, Carmeliet P, Simon MC.

Mol Cell Biol. 2005 Dec;25(23):10479-91.


Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

Brown LM, Cowen RL, Debray C, Eustace A, Erler JT, Sheppard FC, Parker CA, Stratford IJ, Williams KJ.

Mol Pharmacol. 2006 Feb;69(2):411-8. Epub 2005 Oct 27.


Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR.

Cell. 2005 Aug 12;122(3):337-49.

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