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Results: 1 to 20 of 164

1.

A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells.

Choi Y, Yuen C, Maiti SN, Olivares S, Gibbons H, Huls H, Raphael R, Killian TC, Stark DJ, Lee DA, Torikai H, Monticello D, Kelly SS, Kebriaei P, Champlin RE, Biswal SL, Cooper LJ.

Biomed Microdevices. 2010 Oct;12(5):855-63. doi: 10.1007/s10544-010-9440-3.

PMID:
20574820
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety.

Hoyos V, Savoldo B, Quintarelli C, Mahendravada A, Zhang M, Vera J, Heslop HE, Rooney CM, Brenner MK, Dotti G.

Leukemia. 2010 Jun;24(6):1160-70. doi: 10.1038/leu.2010.75. Epub 2010 Apr 29.

PMID:
20428207
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.

Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M.

Mol Ther. 2010 Apr;18(4):666-8. doi: 10.1038/mt.2010.31. No abstract available.

PMID:
20357779
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Safer CARS.

Heslop HE.

Mol Ther. 2010 Apr;18(4):661-2. doi: 10.1038/mt.2010.42. No abstract available.

PMID:
20357776
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans.

Jensen MC, Popplewell L, Cooper LJ, DiGiusto D, Kalos M, Ostberg JR, Forman SJ.

Biol Blood Marrow Transplant. 2010 Sep;16(9):1245-56. doi: 10.1016/j.bbmt.2010.03.014. Epub 2010 Mar 19.

PMID:
20304086
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.

Markley JC, Sadelain M.

Blood. 2010 Apr 29;115(17):3508-19. doi: 10.1182/blood-2009-09-241398. Epub 2010 Feb 26.

PMID:
20190192
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.

Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA.

Mol Ther. 2010 Apr;18(4):843-51. doi: 10.1038/mt.2010.24. Epub 2010 Feb 23.

PMID:
20179677
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Genetic redirection of T cells for cancer therapy.

Westwood JA, Kershaw MH.

J Leukoc Biol. 2010 May;87(5):791-803. doi: 10.1189/jlb.1209824. Epub 2010 Feb 23. Review.

PMID:
20179152
[PubMed - indexed for MEDLINE]
Free Article
9.

Adoptive T cell therapy of cancer.

Brenner MK, Heslop HE.

Curr Opin Immunol. 2010 Apr;22(2):251-7. doi: 10.1016/j.coi.2010.01.020. Epub 2010 Feb 17. Review.

PMID:
20171074
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation.

Micklethwaite KP, Savoldo B, Hanley PJ, Leen AM, Demmler-Harrison GJ, Cooper LJ, Liu H, Gee AP, Shpall EJ, Rooney CM, Heslop HE, Brenner MK, Bollard CM, Dotti G.

Blood. 2010 Apr 1;115(13):2695-703. doi: 10.1182/blood-2009-09-242263. Epub 2010 Jan 28.

PMID:
20110422
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A transposon and transposase system for human application.

Hackett PB, Largaespada DA, Cooper LJ.

Mol Ther. 2010 Apr;18(4):674-83. doi: 10.1038/mt.2010.2. Epub 2010 Jan 26. Review.

PMID:
20104209
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.

Wrzesinski C, Paulos CM, Kaiser A, Muranski P, Palmer DC, Gattinoni L, Yu Z, Rosenberg SA, Restifo NP.

J Immunother. 2010 Jan;33(1):1-7. doi: 10.1097/CJI.0b013e3181b88ffc.

PMID:
19952961
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies.

Manuri PV, Wilson MH, Maiti SN, Mi T, Singh H, Olivares S, Dawson MJ, Huls H, Lee DA, Rao PH, Kaminski JM, Nakazawa Y, Gottschalk S, Kebriaei P, Shpall EJ, Champlin RE, Cooper LJ.

Hum Gene Ther. 2010 Apr;21(4):427-37. doi: 10.1089/hum.2009.114.

PMID:
19905893
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells.

Brown CE, Starr R, Martinez C, Aguilar B, D'Apuzzo M, Todorov I, Shih CC, Badie B, Hudecek M, Riddell SR, Jensen MC.

Cancer Res. 2009 Dec 1;69(23):8886-93. doi: 10.1158/0008-5472.CAN-09-2687. Epub 2009 Nov 10.

PMID:
19903840
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice.

James SE, Orgun NN, Tedder TF, Shlomchik MJ, Jensen MC, Lin Y, Greenberg PD, Press OW.

Blood. 2009 Dec 24;114(27):5454-63. doi: 10.1182/blood-2009-08-232967. Epub 2009 Oct 30.

PMID:
19880489
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Risk in clinical research: size matters!

Lowenstein PR.

Mol Ther. 2009 Nov;17(11):1833-4. doi: 10.1038/mt.2009.242. No abstract available.

PMID:
19876046
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Gene therapy deserves a fresh chance.

[No authors listed]

Nature. 2009 Oct 29;461(7268):1173. doi: 10.1038/4611173a. No abstract available.

PMID:
19865117
[PubMed - indexed for MEDLINE]
18.

Immunotherapy of human cancers using gene modified T lymphocytes.

Vera JF, Brenner MK, Dotti G.

Curr Gene Ther. 2009 Oct;9(5):396-408. Review.

PMID:
19860654
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Engineering lymphocyte subsets: tools, trials and tribulations.

June CH, Blazar BR, Riley JL.

Nat Rev Immunol. 2009 Oct;9(10):704-16. doi: 10.1038/nri2635. Review.

PMID:
19859065
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.

Zhao Y, Wang QJ, Yang S, Kochenderfer JN, Zheng Z, Zhong X, Sadelain M, Eshhar Z, Rosenberg SA, Morgan RA.

J Immunol. 2009 Nov 1;183(9):5563-74. doi: 10.4049/jimmunol.0900447.

PMID:
19843940
[PubMed - indexed for MEDLINE]
Free Article

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