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Items: 1 to 20 of 60

1.

Mechanism of protection by metallothionein against acetaminophen hepatotoxicity.

Saito C, Yan HM, Artigues A, Villar MT, Farhood A, Jaeschke H.

Toxicol Appl Pharmacol. 2010 Jan 15;242(2):182-90. doi: 10.1016/j.taap.2009.10.006. Epub 2009 Oct 14.

2.

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.

Saito C, Zwingmann C, Jaeschke H.

Hepatology. 2010 Jan;51(1):246-54. doi: 10.1002/hep.23267.

3.

Farnesyltransferase inhibitors reduce Ras activation and ameliorate acetaminophen-induced liver injury in mice.

Saha B, Nandi D.

Hepatology. 2009 Nov;50(5):1547-57. doi: 10.1002/hep.23180.

PMID:
19739265
4.

Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.

Hong JY, Lebofsky M, Farhood A, Jaeschke H.

Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G572-81. doi: 10.1152/ajpgi.90435.2008. Epub 2009 Jan 8.

5.

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.

Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M.

Gastroenterology. 2008 Oct;135(4):1311-21. doi: 10.1053/j.gastro.2008.07.006. Epub 2008 Jul 9.

PMID:
18700144
6.

Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.

Bourdi M, Korrapati MC, Chakraborty M, Yee SB, Pohl LR.

Biochem Biophys Res Commun. 2008 Sep 12;374(1):6-10. doi: 10.1016/j.bbrc.2008.06.065. Epub 2008 Jun 27.

7.

Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.

Bajt ML, Yan HM, Farhood A, Jaeschke H.

Toxicol Sci. 2008 Aug;104(2):419-27. doi: 10.1093/toxsci/kfn091. Epub 2008 May 9.

8.

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury.

Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N.

J Biol Chem. 2008 May 16;283(20):13565-77. doi: 10.1074/jbc.M708916200. Epub 2008 Mar 12.

9.

Inhibitors of c-Jun N-terminal kinases: JuNK no more?

Bogoyevitch MA, Arthur PG.

Biochim Biophys Acta. 2008 Jan;1784(1):76-93. Epub 2007 Oct 11. Review.

PMID:
17964301
10.

Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.

Bajt ML, Farhood A, Lemasters JJ, Jaeschke H.

J Pharmacol Exp Ther. 2008 Jan;324(1):8-14. Epub 2007 Sep 28.

11.

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.

Latchoumycandane C, Goh CW, Ong MM, Boelsterli UA.

Hepatology. 2007 Feb;45(2):412-21.

PMID:
17366662
12.

An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins.

Takamura M, Matsuda Y, Yamagiwa S, Tamura Y, Honda Y, Suzuki K, Ichida T, Aoyagi Y.

Life Sci. 2007 Mar 13;80(14):1335-44. Epub 2007 Jan 20.

PMID:
17300814
13.

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.

Henderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ, Sethi T, Simpson KJ.

Gut. 2007 Jul;56(7):982-90. Epub 2006 Dec 21.

14.

Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner.

Wicovsky A, Müller N, Daryab N, Marienfeld R, Kneitz C, Kavuri S, Leverkus M, Baumann B, Wajant H.

J Biol Chem. 2007 Jan 26;282(4):2174-83. Epub 2006 Nov 22.

15.

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes.

Latchoumycandane C, Seah QM, Tan RC, Sattabongkot J, Beerheide W, Boelsterli UA.

Toxicol Appl Pharmacol. 2006 Nov 15;217(1):125-33. Epub 2006 Aug 7.

PMID:
16979204
16.

Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.

Bajt ML, Cover C, Lemasters JJ, Jaeschke H.

Toxicol Sci. 2006 Nov;94(1):217-25. Epub 2006 Aug 8.

17.

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N.

Gastroenterology. 2006 Jul;131(1):165-78.

PMID:
16831600
18.
19.

Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.

Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Czaja MJ.

J Biol Chem. 2006 Jun 2;281(22):15258-67. Epub 2006 Mar 29.

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