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Items: 17

1.

In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes.

Gaidukov L, Bar D, Yacobson S, Naftali E, Kaufman O, Tabakman R, Tawfik DS, Levy-Nissenbaum E.

BMC Clin Pharmacol. 2009 Nov 17;9:18. doi: 10.1186/1472-6904-9-18.

2.

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime.

Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M.

J Med Chem. 2009 Dec 10;52(23):7593-603. doi: 10.1021/jm900433t.

PMID:
19642642
3.

Directed enzyme evolution via small and effective neutral drift libraries.

Gupta RD, Tawfik DS.

Nat Methods. 2008 Nov;5(11):939-42. doi: 10.1038/nmeth.1262. Epub 2008 Oct 19.

PMID:
18931667
4.

Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning.

Stevens RC, Suzuki SM, Cole TB, Park SS, Richter RJ, Furlong CE.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12780-4. doi: 10.1073/pnas.0805865105. Epub 2008 Aug 18.

5.

Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.

Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F.

Biochemistry. 2008 May 6;47(18):5216-24. doi: 10.1021/bi702222x. Epub 2008 Apr 9.

PMID:
18396898
6.

OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides.

Bird SB, Sutherland TD, Gresham C, Oakeshott J, Scott C, Eddleston M.

Toxicology. 2008 May 21;247(2-3):88-92. doi: 10.1016/j.tox.2008.02.005. Epub 2008 Mar 10.

7.

Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase.

Yeung DT, Smith JR, Sweeney RE, Lenz DE, Cerasoli DM.

FEBS J. 2007 Mar;274(5):1183-91. Epub 2007 Feb 5.

8.

Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity.

Amitai G, Adani R, Yacov G, Yishay S, Teitlboim S, Tveria L, Limanovich O, Kushnir M, Meshulam H.

Toxicology. 2007 Apr 20;233(1-3):187-98. Epub 2006 Oct 13.

PMID:
17129656
9.

Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase.

Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H.

FEBS J. 2006 May;273(9):1906-19.

10.

The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases.

Khersonsky O, Tawfik DS.

J Biol Chem. 2006 Mar 17;281(11):7649-56. Epub 2006 Jan 10.

11.

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.

Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS.

Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):482-7. Epub 2003 Dec 26.

12.

A new and rapid colorimetric determination of acetylcholinesterase activity.

ELLMAN GL, COURTNEY KD, ANDRES V Jr, FEATHER-STONE RM.

Biochem Pharmacol. 1961 Jul;7:88-95. No abstract available.

PMID:
13726518
13.

Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.

Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I.

Biochemistry. 2002 Mar 19;41(11):3555-64.

PMID:
11888271
14.

Stereoselective detoxification of chiral sarin and soman analogues by phosphotriesterase.

Li WS, Lum KT, Chen-Goodspeed M, Sogorb MA, Raushel FM.

Bioorg Med Chem. 2001 Aug;9(8):2083-91.

PMID:
11504644
15.
16.

Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice.

Ashani Y, Rothschild N, Segall Y, Levanon D, Raveh L.

Life Sci. 1991;49(5):367-74.

PMID:
1649941
17.

Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters.

Raveh L, Segall Y, Leader H, Rothschild N, Levanon D, Henis Y, Ashani Y.

Biochem Pharmacol. 1992 Jul 22;44(2):397-400.

PMID:
1322669
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