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Results: 1 to 20 of 49

References for PMC Articles for PubMed (Select 20227039)

1.

The pharmacology of mTOR inhibition.

Guertin DA, Sabatini DM.

Sci Signal. 2009 Apr 21;2(67):pe24. doi: 10.1126/scisignal.267pe24.

PMID:
19383975
2.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM.

PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.

3.

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS.

J Biol Chem. 2009 Mar 20;284(12):8023-32. doi: 10.1074/jbc.M900301200. Epub 2009 Jan 15.

4.

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.

Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D.

Nature. 2008 Dec 18;456(7224):971-5. doi: 10.1038/nature07449. Epub 2008 Nov 16.

5.

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.

Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17414-9. doi: 10.1073/pnas.0809136105. Epub 2008 Oct 27.

6.

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation.

Alliouachene S, Tuttle RL, Boumard S, Lapointe T, Berissi S, Germain S, Jaubert F, Tosh D, Birnbaum MJ, Pende M.

J Clin Invest. 2008 Nov;118(11):3629-38. doi: 10.1172/JCI35237. Epub 2008 Oct 9.

7.

PI3K pathway alterations in cancer: variations on a theme.

Yuan TL, Cantley LC.

Oncogene. 2008 Sep 18;27(41):5497-510. doi: 10.1038/onc.2008.245. Review.

8.

mTORC1 promotes survival through translational control of Mcl-1.

Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8. doi: 10.1073/pnas.0804821105. Epub 2008 Jul 29.

9.

A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.

Tan Y, Timakhov RA, Rao M, Altomare DA, Xu J, Liu Z, Gao Q, Jhanwar SC, Di Cristofano A, Wiest DL, Knepper JE, Testa JR.

Cancer Res. 2008 Mar 1;68(5):1296-302. doi: 10.1158/0008-5472.CAN-07-3218.

10.

Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM.

Cancer Cell. 2007 Jul;12(1):9-22. Review.

11.

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12105-10. Epub 2007 Jul 3.

12.

Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.

Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN.

J Immunol. 2007 May 1;178(9):5443-53.

13.

The Minute Reaction in the Development of DROSOPHILA MELANOGASTER.

Schultz J.

Genetics. 1929 Jul;14(4):366-419. No abstract available.

14.

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

Skeen JE, Bhaskar PT, Chen CC, Chen WS, Peng XD, Nogueira V, Hahn-Windgassen A, Kiyokawa H, Hay N.

Cancer Cell. 2006 Oct;10(4):269-80.

15.

A survival guide to early T cell development.

Ciofani M, Zúñiga-Pflücker JC.

Immunol Res. 2006;34(2):117-32. Review.

PMID:
16760572
16.

Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita.

Yoon A, Peng G, Brandenburger Y, Zollo O, Xu W, Rego E, Ruggero D.

Science. 2006 May 12;312(5775):902-6. Erratum in: Science. 2006 Sep;313(5791):1238. Brandenburg, Yves [corrected to Brandenburger, Yves].

17.

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

Ruvinsky I, Meyuhas O.

Trends Biochem Sci. 2006 Jun;31(6):342-8. Epub 2006 May 6. Review.

PMID:
16679021
18.

The Akt of translational control.

Ruggero D, Sonenberg N.

Oncogene. 2005 Nov 14;24(50):7426-34. Review.

PMID:
16288289
19.

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.

Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, Dor Y, Zisman P, Meyuhas O.

Genes Dev. 2005 Sep 15;19(18):2199-211.

20.

Upstream and downstream of mTOR.

Hay N, Sonenberg N.

Genes Dev. 2004 Aug 15;18(16):1926-45. Review.

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