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Cancer statistics, 2009.

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ.

CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49. doi: 10.3322/caac.20006. Epub 2009 May 27.


Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA.

Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.


Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM.

Gastroenterology. 2009 Aug;137(2):629-38. doi: 10.1053/j.gastro.2009.04.059. Epub 2009 May 7.


Expression and regulation of hedgehog signaling pathway in pancreatic cancer.

Yang Y, Tian X, Xie X, Zhuang Y, Wu W, Wang W.

Langenbecks Arch Surg. 2010 Jun;395(5):515-25. doi: 10.1007/s00423-009-0493-9. Epub 2009 Apr 25.


Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.

Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4254-9. doi: 10.1073/pnas.0813203106. Epub 2009 Feb 25.


GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.

Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D.

Genes Dev. 2009 Jan 1;23(1):24-36. doi: 10.1101/gad.1753809.


Hedgehog signaling in development and cancer.

Jiang J, Hui CC.

Dev Cell. 2008 Dec;15(6):801-12. doi: 10.1016/j.devcel.2008.11.010. Review.


Sonic hedgehog promotes desmoplasia in pancreatic cancer.

Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T, Ouellette MM, Hollingsworth MA.

Clin Cancer Res. 2008 Oct 1;14(19):5995-6004. doi: 10.1158/1078-0432.CCR-08-0291.


An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JB, Habbe N, Karikari C, Mullendore M, Gabrielson KL, Sharma R, Matsui W, Maitra A.

Mol Cancer Ther. 2008 Sep;7(9):2725-35. doi: 10.1158/1535-7163.MCT-08-0573.


Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW.

Science. 2008 Sep 26;321(5897):1801-6. doi: 10.1126/science.1164368. Epub 2008 Sep 4.


A paracrine requirement for hedgehog signalling in cancer.

Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ.

Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.


Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.

Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C, Bardeesy N, Ouellette MM, Yu W, Maitra A.

Gut. 2008 Oct;57(10):1420-30. doi: 10.1136/gut.2007.148189. Epub 2008 May 30.


Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas.

Fukushima N, Kikuchi Y, Nishiyama T, Kudo A, Fukayama M.

Mod Pathol. 2008 Aug;21(8):1044-53. doi: 10.1038/modpathol.2008.77. Epub 2008 May 16.


Insulin-like growth factor binding protein-3 (IGFBP-3) in the prostate and in prostate cancer: local production, distribution and secretion pattern indicate a role in stromal-epithelial interaction.

Massoner P, Haag P, Seifarth C, Jurgeit A, Rogatsch H, Doppler W, Bartsch G, Klocker H.

Prostate. 2008 Aug 1;68(11):1165-78. doi: 10.1002/pros.20785.


Pancreatic cancer associated fibroblasts display normal allelotypes.

Walter K, Omura N, Hong SM, Griffith M, Goggins M.

Cancer Biol Ther. 2008 Jun;7(6):882-8. Epub 2008 Mar 8.


Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok M, Lewis BC.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5103-8. Epub 2007 Mar 19.


Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.

Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, Iacobuzio-Donahue C, Jimeno A, Gabrielson KL, Matsui W, Maitra A.

Cancer Res. 2007 Mar 1;67(5):2187-96.


Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma.

Infante JR, Matsubayashi H, Sato N, Tonascia J, Klein AP, Riall TA, Yeo C, Iacobuzio-Donahue C, Goggins M.

J Clin Oncol. 2007 Jan 20;25(3):319-25.


Targeting the Hedgehog pathway in cancer.

Rubin LL, de Sauvage FJ.

Nat Rev Drug Discov. 2006 Dec;5(12):1026-33. Review.


Stromal fibroblasts in cancer: a novel tumor-promoting cell type.

Orimo A, Weinberg RA.

Cell Cycle. 2006 Aug;5(15):1597-601. Epub 2006 Aug 1. Review.

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