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Results: 1 to 20 of 47

References for PMC Articles for PubMed (Select 20202892)

1.

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.

Peng LF, Stanton BZ, Maloof N, Wang X, Schreiber SL.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6319-25. doi: 10.1016/j.bmcl.2009.09.089. Epub 2009 Sep 25.

2.

Antibiotics for emerging pathogens.

Fischbach MA, Walsh CT.

Science. 2009 Aug 28;325(5944):1089-93. doi: 10.1126/science.1176667. Review.

3.

Mimicking the BH3 domain to kill cancer cells.

Ni Chonghaile T, Letai A.

Oncogene. 2008 Dec;27 Suppl 1:S149-57. doi: 10.1038/onc.2009.52. Review.

4.

Chemistry and biology of non-tetramic gamma-hydroxy-gamma-lactams and gamma-alkylidene-gamma-lactams from natural sources.

Nay B, Riache N, Evanno L.

Nat Prod Rep. 2009 Aug;26(8):1044-62. doi: 10.1039/b903905h. Epub 2009 Jun 11. Review.

PMID:
19636449
5.

Quantifying biogenic bias in screening libraries.

Hert J, Irwin JJ, Laggner C, Keiser MJ, Shoichet BK.

Nat Chem Biol. 2009 Jul;5(7):479-83. doi: 10.1038/nchembio.180. Epub 2009 May 31.

6.

The spliceosome: design principles of a dynamic RNP machine.

Wahl MC, Will CL, Lührmann R.

Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009. Review.

7.

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.

Kang MH, Reynolds CP.

Clin Cancer Res. 2009 Feb 15;15(4):1126-32. doi: 10.1158/1078-0432.CCR-08-0144. Review.

8.

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL.

Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18.

9.

Inhibition of transcription factors with small organic molecules.

Berg T.

Curr Opin Chem Biol. 2008 Aug;12(4):464-71. doi: 10.1016/j.cbpa.2008.07.023. Epub 2008 Aug 13. Review.

PMID:
18706517
10.

The exploration of macrocycles for drug discovery--an underexploited structural class.

Driggers EM, Hale SP, Lee J, Terrett NK.

Nat Rev Drug Discov. 2008 Jul;7(7):608-24. doi: 10.1038/nrd2590. Review.

PMID:
18591981
11.

Structural consequences of nucleophosmin mutations in acute myeloid leukemia.

Grummitt CG, Townsley FM, Johnson CM, Warren AJ, Bycroft M.

J Biol Chem. 2008 Aug 22;283(34):23326-32. doi: 10.1074/jbc.M801706200. Epub 2008 May 29.

12.

The impact of natural products upon modern drug discovery.

Ganesan A.

Curr Opin Chem Biol. 2008 Jun;12(3):306-17. doi: 10.1016/j.cbpa.2008.03.016. Review.

PMID:
18423384
13.

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

Dobson PD, Kell DB.

Nat Rev Drug Discov. 2008 Mar;7(3):205-20. doi: 10.1038/nrd2438. Review.

PMID:
18309312
14.

Anti-MRSA agent discovery using diversity-oriented synthesis.

Thomas GL, Spandl RJ, Glansdorp FG, Welch M, Bender A, Cockfield J, Lindsay JA, Bryant C, Brown DF, Loiseleur O, Rudyk H, Ladlow M, Spring DR.

Angew Chem Int Ed Engl. 2008;47(15):2808-12. doi: 10.1002/anie.200705415. No abstract available.

PMID:
18307176
15.

Physicochemical properties of antibacterial compounds: implications for drug discovery.

O'Shea R, Moser HE.

J Med Chem. 2008 May 22;51(10):2871-8. doi: 10.1021/jm700967e. Epub 2008 Feb 9. No abstract available.

PMID:
18260614
16.

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

Wells JA, McClendon CL.

Nature. 2007 Dec 13;450(7172):1001-9. Review.

PMID:
18075579
17.

The natural product avrainvillamide binds to the oncoprotein nucleophosmin.

Wulff JE, Siegrist R, Myers AG.

J Am Chem Soc. 2007 Nov 21;129(46):14444-51. Epub 2007 Oct 25.

18.

Action of atrop-abyssomicin C as an inhibitor of 4-amino-4-deoxychorismate synthase PabB.

Keller S, Schadt HS, Ortel I, Süssmuth RD.

Angew Chem Int Ed Engl. 2007;46(43):8284-6. No abstract available.

PMID:
17886307
19.

Targeting the spliceosome.

Rymond B.

Nat Chem Biol. 2007 Sep;3(9):533-5. No abstract available.

PMID:
17710096
20.

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M, Mizui Y.

Nat Chem Biol. 2007 Sep;3(9):570-5. Epub 2007 Jul 22.

PMID:
17643112
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